Role of the Microbiome in Aedes spp. Vector Competence : What Do We Know?
Aedes aegypti and Aedes albopictus are the vectors of important arboviruses: dengue fever, chikungunya, Zika, and yellow fever. Female mosquitoes acquire arboviruses by feeding on the infected host blood, thus being able to transmit it to their offspring. The intrinsic ability of a vector to infect itself and transmit a pathogen is known as vector competence. Several factors influence the susceptibility of these females to be infected by these arboviruses, such as the activation of the innate immune system through the Toll, immunodeficiency (Imd), JAK-STAT pathways, and the interference of specific antiviral response pathways of RNAi. It is also believed that the presence of non-pathogenic microorganisms in the microbiota of these arthropods could influence this immune response, as it provides a baseline activation of the innate immune system, which may generate resistance against arboviruses. In addition, this microbiome has direct action against arboviruses, mainly due to the ability of Wolbachia spp. to block viral genome replication, added to the competition for resources within the mosquito organism. Despite major advances in the area, studies are still needed to evaluate the microbiota profiles of Aedes spp. and their vector competence, as well as further exploration of the individual roles of microbiome components in activating the innate immune system.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
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| Enthalten in: |
Viruses - 15(2023), 3 vom: 17. März |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ferreira, Qesya Rodrigues [VerfasserIn] |
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| Links: |
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| Themen: |
Aedes |
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| Anmerkungen: |
Date Completed 31.03.2023 Date Revised 01.11.2023 published: Electronic Citation Status MEDLINE |
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| doi: |
10.3390/v15030779 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM354974270 |
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| 520 | |a Aedes aegypti and Aedes albopictus are the vectors of important arboviruses: dengue fever, chikungunya, Zika, and yellow fever. Female mosquitoes acquire arboviruses by feeding on the infected host blood, thus being able to transmit it to their offspring. The intrinsic ability of a vector to infect itself and transmit a pathogen is known as vector competence. Several factors influence the susceptibility of these females to be infected by these arboviruses, such as the activation of the innate immune system through the Toll, immunodeficiency (Imd), JAK-STAT pathways, and the interference of specific antiviral response pathways of RNAi. It is also believed that the presence of non-pathogenic microorganisms in the microbiota of these arthropods could influence this immune response, as it provides a baseline activation of the innate immune system, which may generate resistance against arboviruses. In addition, this microbiome has direct action against arboviruses, mainly due to the ability of Wolbachia spp. to block viral genome replication, added to the competition for resources within the mosquito organism. Despite major advances in the area, studies are still needed to evaluate the microbiota profiles of Aedes spp. and their vector competence, as well as further exploration of the individual roles of microbiome components in activating the innate immune system | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Aedes | |
| 650 | 4 | |a arboviruses | |
| 650 | 4 | |a microbiota | |
| 650 | 4 | |a mosquito vectors | |
| 650 | 4 | |a vector borne diseases | |
| 650 | 4 | |a vector competence | |
| 700 | 1 | |a Lemos, Fabian Fellipe Bueno |e verfasserin |4 aut | |
| 700 | 1 | |a Moura, Matheus Nascimento |e verfasserin |4 aut | |
| 700 | 1 | |a Nascimento, Jéssica Oliveira de Souza |e verfasserin |4 aut | |
| 700 | 1 | |a Novaes, Ana Flávia |e verfasserin |4 aut | |
| 700 | 1 | |a Barcelos, Isadora Souza |e verfasserin |4 aut | |
| 700 | 1 | |a Fernandes, Larissa Alves |e verfasserin |4 aut | |
| 700 | 1 | |a Amaral, Liliany Souza de Brito |e verfasserin |4 aut | |
| 700 | 1 | |a Barreto, Fernanda Khouri |e verfasserin |4 aut | |
| 700 | 1 | |a Melo, Fabrício Freire de |e verfasserin |4 aut | |
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