Paraneoplastic Kelch-like protein 11 antibody-associated cerebellar and limbic encephalitis caused by metastatic "burned-out" seminoma - A scar(r)y phenomenon
Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved..
INTRODUCTION: The diagnosis of paraneoplastic neurologic syndromes is challenging when the primary tumor masquerades as scar tissue (i.e. "burned-out").
METHODS: Case report.
RESULTS: A 45-year-old male patient presented with progressive cerebellar symptoms and hearing loss. Initial screening for malignancy and extensive testing of paraneoplastic and autoimmune neuronal antibodies gave negative results. Repeated whole-body FDG-PET CT revealed a single paraaortic lymphadenopathy, metastasis of a regressed testicular seminoma. Anti-Kelch-like protein-11 (KLHL11) encephalitis was finally diagnosed.
CONCLUSION: Our case highlights the importance of continued efforts to find an often burned-out testicular cancer in patients with a highly unique clinical presentation of KLHL11 encephalitis.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:378 |
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| Enthalten in: |
Journal of neuroimmunology - 378(2023) vom: 15. Mai, Seite 578073 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Gyongyosi, Benedek [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 12.05.2023 Date Revised 16.06.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jneuroim.2023.578073 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM354946463 |
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| 100 | 1 | |a Gyongyosi, Benedek |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Paraneoplastic Kelch-like protein 11 antibody-associated cerebellar and limbic encephalitis caused by metastatic "burned-out" seminoma - A scar(r)y phenomenon |
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| 500 | |a Date Completed 12.05.2023 | ||
| 500 | |a Date Revised 16.06.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved. | ||
| 520 | |a INTRODUCTION: The diagnosis of paraneoplastic neurologic syndromes is challenging when the primary tumor masquerades as scar tissue (i.e. "burned-out") | ||
| 520 | |a METHODS: Case report | ||
| 520 | |a RESULTS: A 45-year-old male patient presented with progressive cerebellar symptoms and hearing loss. Initial screening for malignancy and extensive testing of paraneoplastic and autoimmune neuronal antibodies gave negative results. Repeated whole-body FDG-PET CT revealed a single paraaortic lymphadenopathy, metastasis of a regressed testicular seminoma. Anti-Kelch-like protein-11 (KLHL11) encephalitis was finally diagnosed | ||
| 520 | |a CONCLUSION: Our case highlights the importance of continued efforts to find an often burned-out testicular cancer in patients with a highly unique clinical presentation of KLHL11 encephalitis | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Burned-out seminoma | |
| 650 | 4 | |a Cerebellar syndrome | |
| 650 | 4 | |a Kelch-like protein 11 antibody | |
| 650 | 4 | |a Limbic encephalitis | |
| 650 | 4 | |a Paraneoplastic syndrome | |
| 650 | 7 | |a Autoantibodies |2 NLM | |
| 650 | 7 | |a KLHL11 protein, human |2 NLM | |
| 700 | 1 | |a Magyar-Stang, Rita |e verfasserin |4 aut | |
| 700 | 1 | |a Takacs, Timea |e verfasserin |4 aut | |
| 700 | 1 | |a Szekely, Eszter |e verfasserin |4 aut | |
| 700 | 1 | |a Illes, Zsolt |e verfasserin |4 aut | |
| 700 | 1 | |a Nilsson, Christine |e verfasserin |4 aut | |
| 700 | 1 | |a Gyorke, Tamas |e verfasserin |4 aut | |
| 700 | 1 | |a Barsi, Peter |e verfasserin |4 aut | |
| 700 | 1 | |a Juhasz, Daniel |e verfasserin |4 aut | |
| 700 | 1 | |a Banky, Balazs |e verfasserin |4 aut | |
| 700 | 1 | |a Bereczki, Daniel |e verfasserin |4 aut | |
| 700 | 1 | |a Honnorat, Jerome |e verfasserin |4 aut | |
| 700 | 1 | |a Gunda, Bence |e verfasserin |4 aut | |
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