Serum Vitamin D Concentration Is Lower in Patients with Tinnitus : A Meta-Analysis of Observational Studies
BACKGROUND: Tinnitus is a highly prevalent and frequently disabling condition, such that the identification of possible causal mechanisms would yield significant clinical and social benefits. Since vitamin D (Vit D) is involved in the pathogenesis of several ear disturbances, we review here the current scientific literature addressing the relationship between Vit D status and tinnitus.
METHODS: An electronic search was conducted in PubMed, Scopus and Web of Science with the keywords "tinnitus" and "Vitamin D" or "Vit D" or "25OH-D" or "cholecalciferol" or "ergocalciferol" or "hydroxycholecalciferol", without date (i.e., up to 8 February 2023) or language restrictions, in accordance with a protocol based on the transparent reporting of systematic reviews and meta-analysis (PRISMA) 2020 checklist, for identifying studies which assayed serum Vit D concentration in patients with or without tinnitus.
RESULTS: Three observational, case-control studies encompassing four cohorts and totaling 468 patients with (n = 268) or without tinnitus (n = 200) were included in this meta-analysis. Pooled analysis with quality effects models evidenced significantly reduced serum Vit D levels in patients with tinnitus compared to those without (weighted mean difference [WMD], -6.2 ng/mL; 95% CI, -10.3 to -2.1 ng/mL; I2, 56%). Serum Vit D was found to be 22% lower in patients with tinnitus compared to those without.
CONCLUSIONS: Lower serum Vit D levels may be associated with tinnitus, thus paving the way to plan future trials aimed at exploring whether Vit D supplementation may aid in preventing and/or improving tinnitus.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
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| Enthalten in: |
Diagnostics (Basel, Switzerland) - 13(2023), 6 vom: 08. März |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Nocini, Riccardo [VerfasserIn] |
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| Links: |
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| Themen: |
25OH-D |
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| Anmerkungen: |
Date Revised 31.03.2023 published: Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3390/diagnostics13061037 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM354853082 |
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| 520 | |a BACKGROUND: Tinnitus is a highly prevalent and frequently disabling condition, such that the identification of possible causal mechanisms would yield significant clinical and social benefits. Since vitamin D (Vit D) is involved in the pathogenesis of several ear disturbances, we review here the current scientific literature addressing the relationship between Vit D status and tinnitus | ||
| 520 | |a METHODS: An electronic search was conducted in PubMed, Scopus and Web of Science with the keywords "tinnitus" and "Vitamin D" or "Vit D" or "25OH-D" or "cholecalciferol" or "ergocalciferol" or "hydroxycholecalciferol", without date (i.e., up to 8 February 2023) or language restrictions, in accordance with a protocol based on the transparent reporting of systematic reviews and meta-analysis (PRISMA) 2020 checklist, for identifying studies which assayed serum Vit D concentration in patients with or without tinnitus | ||
| 520 | |a RESULTS: Three observational, case-control studies encompassing four cohorts and totaling 468 patients with (n = 268) or without tinnitus (n = 200) were included in this meta-analysis. Pooled analysis with quality effects models evidenced significantly reduced serum Vit D levels in patients with tinnitus compared to those without (weighted mean difference [WMD], -6.2 ng/mL; 95% CI, -10.3 to -2.1 ng/mL; I2, 56%). Serum Vit D was found to be 22% lower in patients with tinnitus compared to those without | ||
| 520 | |a CONCLUSIONS: Lower serum Vit D levels may be associated with tinnitus, thus paving the way to plan future trials aimed at exploring whether Vit D supplementation may aid in preventing and/or improving tinnitus | ||
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