Recent Advances in Organ-on-Chips Integrated with Bioprinting Technologies for Drug Screening
© 2023 The Authors. Advanced Healthcare Materials published by Wiley-VCH GmbH..
Currently, the demand for more reliable drug screening devices has made scientists and researchers develop novel potential approaches to offer an alternative to animal studies. Organ-on-chips are newly emerged platforms for drug screening and disease metabolism investigation. These microfluidic devices attempt to recapitulate the physiological and biological properties of different organs and tissues using human-derived cells. Recently, the synergistic combination of additive manufacturing and microfluidics has shown a promising impact on improving a wide array of biological models. In this review, different methods are classified using bioprinting to achieve the relevant biomimetic models in organ-on-chips, boosting the efficiency of these devices to produce more reliable data for drug investigations. In addition to the tissue models, the influence of additive manufacturing on microfluidic chip fabrication is discussed, and their biomedical applications are reviewed.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
Advanced healthcare materials - 12(2023), 20 vom: 03. Aug., Seite e2203172 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Tabatabaei Rezaei, Nima [VerfasserIn] |
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| Links: |
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| Themen: |
3D bioprinting |
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| Anmerkungen: |
Date Completed 09.08.2023 Date Revised 09.09.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/adhm.202203172 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Currently, the demand for more reliable drug screening devices has made scientists and researchers develop novel potential approaches to offer an alternative to animal studies. Organ-on-chips are newly emerged platforms for drug screening and disease metabolism investigation. These microfluidic devices attempt to recapitulate the physiological and biological properties of different organs and tissues using human-derived cells. Recently, the synergistic combination of additive manufacturing and microfluidics has shown a promising impact on improving a wide array of biological models. In this review, different methods are classified using bioprinting to achieve the relevant biomimetic models in organ-on-chips, boosting the efficiency of these devices to produce more reliable data for drug investigations. In addition to the tissue models, the influence of additive manufacturing on microfluidic chip fabrication is discussed, and their biomedical applications are reviewed | ||
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