The emerging roles of leukocyte cell-derived chemotaxin-2 in immune diseases : From mechanisms to therapeutic potential
Copyright © 2023 Zhu, Liu, Li, Tao, Yang and Chen..
Leukocyte cell-derived chemotaxin-2 (LECT2, also named ChM-II), initially identified as a chemokine mediating neutrophil migration, is a multifunctional secreted factor involved in diverse physiological and pathological processes. The high sequence similarity of LECT2 among different vertebrates makes it possible to explore its functions by using comparative biology. LECT2 is associated with many immune processes and immune-related diseases via its binding to cell surface receptors such as CD209a, Tie1, and Met in various cell types. In addition, the misfolding LECT2 leads to the amyloidosis of several crucial tissues (kidney, liver, and lung, etc.) by inducing the formation of insoluble fibrils. However, the mechanisms of LECT2-mediated diverse immune pathogenic conditions in various tissues remain to be fully elucidated due to the functional and signaling heterogeneity. Here, we provide a comprehensive summary of the structure, the "double-edged sword" function, and the extensive signaling pathways of LECT2 in immune diseases, as well as the potential applications of LECT2 in therapeutic interventions in preclinical or clinical trials. This review provides an integrated perspective on the current understanding of how LECT2 is associated with immune diseases, with the aim of facilitating the development of drugs or probes against LECT2 for the theranostics of immune-related diseases.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
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| Enthalten in: |
Frontiers in immunology - 14(2023) vom: 28., Seite 1158083 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhu, Ming-Hui [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 31.03.2023 Date Revised 31.03.2023 published: Electronic-eCollection Citation Status MEDLINE |
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| doi: |
10.3389/fimmu.2023.1158083 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM354742663 |
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| 245 | 1 | 4 | |a The emerging roles of leukocyte cell-derived chemotaxin-2 in immune diseases |b From mechanisms to therapeutic potential |
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| 500 | |a Date Revised 31.03.2023 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 Zhu, Liu, Li, Tao, Yang and Chen. | ||
| 520 | |a Leukocyte cell-derived chemotaxin-2 (LECT2, also named ChM-II), initially identified as a chemokine mediating neutrophil migration, is a multifunctional secreted factor involved in diverse physiological and pathological processes. The high sequence similarity of LECT2 among different vertebrates makes it possible to explore its functions by using comparative biology. LECT2 is associated with many immune processes and immune-related diseases via its binding to cell surface receptors such as CD209a, Tie1, and Met in various cell types. In addition, the misfolding LECT2 leads to the amyloidosis of several crucial tissues (kidney, liver, and lung, etc.) by inducing the formation of insoluble fibrils. However, the mechanisms of LECT2-mediated diverse immune pathogenic conditions in various tissues remain to be fully elucidated due to the functional and signaling heterogeneity. Here, we provide a comprehensive summary of the structure, the "double-edged sword" function, and the extensive signaling pathways of LECT2 in immune diseases, as well as the potential applications of LECT2 in therapeutic interventions in preclinical or clinical trials. This review provides an integrated perspective on the current understanding of how LECT2 is associated with immune diseases, with the aim of facilitating the development of drugs or probes against LECT2 for the theranostics of immune-related diseases | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a LECT2 | |
| 650 | 4 | |a LECT2 receptor | |
| 650 | 4 | |a comparative immunology | |
| 650 | 4 | |a immune regulation | |
| 650 | 4 | |a inflammation-related diseases | |
| 650 | 7 | |a CD8 Antigens |2 NLM | |
| 650 | 7 | |a Chemotactic Factors |2 NLM | |
| 650 | 7 | |a Receptors, Cell Surface |2 NLM | |
| 700 | 1 | |a Liu, Yan-Jun |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Chang-Yun |e verfasserin |4 aut | |
| 700 | 1 | |a Tao, Fan |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Guan-Jun |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Jiong |e verfasserin |4 aut | |
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