Microneedle Device Delivering Aggregation-Induced Emission Photosensitizers for Enhanced Metronomic Photodynamic Therapy of Cancer
Metronomic photodynamic therapy (mPDT), which induces cancer cell death by prolonged intermittent continuous irradiation at lower light power, has profoundly promising applications. However, the photobleaching sensitivity of the photosensitizer (PS) and the difficulty of delivery pose barriers to the clinical application of mPDT. Here, we constructed a microneedle-based device (MicroneedlesAIE PSs) that combined with aggregation-induced emission (AIE) PSs to achieve enhanced mPDT for cancer. Due to the strong anti-photobleaching property of the AIE PS, it can maintain superior photosensitivity even after long-time light exposure. The delivery of the AIE PS to the tumor through a microneedle device allows for greater uniformity and depth. This Microneedles@AIE PSs-based mPDT (M-mPDT) offers better treatment outcomes and easier access, and combining M-mPDT with surgery or immunotherapy can also significantly improve the effectiveness of these clinical therapies. In conclusion, M-mPDT offers a promising strategy for the clinical application of PDT due to its better efficacy and convenience.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
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| Enthalten in: |
ACS applied materials & interfaces - 15(2023), 13 vom: 05. Apr., Seite 16526-16538 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Dai, Jun [VerfasserIn] |
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| Links: |
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| Themen: |
Aggregation-induced emission |
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| Anmerkungen: |
Date Completed 07.04.2023 Date Revised 11.04.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1021/acsami.3c01682 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM354715887 |
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| 520 | |a Metronomic photodynamic therapy (mPDT), which induces cancer cell death by prolonged intermittent continuous irradiation at lower light power, has profoundly promising applications. However, the photobleaching sensitivity of the photosensitizer (PS) and the difficulty of delivery pose barriers to the clinical application of mPDT. Here, we constructed a microneedle-based device (MicroneedlesAIE PSs) that combined with aggregation-induced emission (AIE) PSs to achieve enhanced mPDT for cancer. Due to the strong anti-photobleaching property of the AIE PS, it can maintain superior photosensitivity even after long-time light exposure. The delivery of the AIE PS to the tumor through a microneedle device allows for greater uniformity and depth. This Microneedles@AIE PSs-based mPDT (M-mPDT) offers better treatment outcomes and easier access, and combining M-mPDT with surgery or immunotherapy can also significantly improve the effectiveness of these clinical therapies. In conclusion, M-mPDT offers a promising strategy for the clinical application of PDT due to its better efficacy and convenience | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a aggregation-induced emission | |
| 650 | 4 | |a immunotherapy | |
| 650 | 4 | |a metronomic photodynamic therapy | |
| 650 | 4 | |a microneedle | |
| 650 | 4 | |a surgery | |
| 650 | 7 | |a Photosensitizing Agents |2 NLM | |
| 700 | 1 | |a Wei, Simin |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Jiarong |e verfasserin |4 aut | |
| 700 | 1 | |a Xue, Huiying |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Zhaojun |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Meng |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Lou, Xiaoding |e verfasserin |4 aut | |
| 700 | 1 | |a Xia, Fan |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Shixuan |e verfasserin |4 aut | |
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