The impact of the COVID-19 pandemic upon pancreatic cancer treatment (CONTACT Study) : a UK national observational cohort study
© 2023. The Author(s)..
INTRODUCTION: CONTACT is a national multidisciplinary study assessing the impact of the COVID-19 pandemic upon diagnostic and treatment pathways among patients with pancreatic ductal adenocarcinoma (PDAC).
METHODS: The treatment of consecutive patients with newly diagnosed PDAC from a pre-COVID-19 pandemic cohort (07/01/2019-03/03/2019) were compared to a cohort diagnosed during the first wave of the UK pandemic ('COVID' cohort, 16/03/2020-10/05/2020), with 12-month follow-up.
RESULTS: Among 984 patients (pre-COVID: n = 483, COVID: n = 501), the COVID cohort was less likely to receive staging investigations other than CT scanning (29.5% vs. 37.2%, p = 0.010). Among patients treated with curative intent, there was a reduction in the proportion of patients recommended surgery (54.5% vs. 76.6%, p = 0.001) and increase in the proportion recommended upfront chemotherapy (45.5% vs. 23.4%, p = 0.002). Among patients on a non-curative pathway, fewer patients were recommended (47.4% vs. 57.3%, p = 0.004) or received palliative anti-cancer therapy (20.5% vs. 26.5%, p = 0.045). Ultimately, fewer patients in the COVID cohort underwent surgical resection (6.4% vs. 9.3%, p = 0.036), whilst more patients received no anti-cancer treatment (69.3% vs. 59.2% p = 0.009). Despite these differences, there was no difference in median overall survival between the COVID and pre-COVID cohorts, (3.5 (IQR 2.8-4.1) vs. 4.4 (IQR 3.6-5.2) months, p = 0.093).
CONCLUSION: Pathways for patients with PDAC were significantly disrupted during the first wave of the COVID-19 pandemic, with fewer patients receiving standard treatments. However, no significant impact on survival was discerned.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:128 |
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| Enthalten in: |
British journal of cancer - 128(2023), 10 vom: 23. Mai, Seite 1922-1932 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hall, Lewis A [VerfasserIn] |
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| Anmerkungen: |
Date Completed 01.05.2023 Date Revised 28.02.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1038/s41416-023-02220-2 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM354645323 |
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| 100 | 1 | |a Hall, Lewis A |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The impact of the COVID-19 pandemic upon pancreatic cancer treatment (CONTACT Study) |b a UK national observational cohort study |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Completed 01.05.2023 | ||
| 500 | |a Date Revised 28.02.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023. The Author(s). | ||
| 520 | |a INTRODUCTION: CONTACT is a national multidisciplinary study assessing the impact of the COVID-19 pandemic upon diagnostic and treatment pathways among patients with pancreatic ductal adenocarcinoma (PDAC) | ||
| 520 | |a METHODS: The treatment of consecutive patients with newly diagnosed PDAC from a pre-COVID-19 pandemic cohort (07/01/2019-03/03/2019) were compared to a cohort diagnosed during the first wave of the UK pandemic ('COVID' cohort, 16/03/2020-10/05/2020), with 12-month follow-up | ||
| 520 | |a RESULTS: Among 984 patients (pre-COVID: n = 483, COVID: n = 501), the COVID cohort was less likely to receive staging investigations other than CT scanning (29.5% vs. 37.2%, p = 0.010). Among patients treated with curative intent, there was a reduction in the proportion of patients recommended surgery (54.5% vs. 76.6%, p = 0.001) and increase in the proportion recommended upfront chemotherapy (45.5% vs. 23.4%, p = 0.002). Among patients on a non-curative pathway, fewer patients were recommended (47.4% vs. 57.3%, p = 0.004) or received palliative anti-cancer therapy (20.5% vs. 26.5%, p = 0.045). Ultimately, fewer patients in the COVID cohort underwent surgical resection (6.4% vs. 9.3%, p = 0.036), whilst more patients received no anti-cancer treatment (69.3% vs. 59.2% p = 0.009). Despite these differences, there was no difference in median overall survival between the COVID and pre-COVID cohorts, (3.5 (IQR 2.8-4.1) vs. 4.4 (IQR 3.6-5.2) months, p = 0.093) | ||
| 520 | |a CONCLUSION: Pathways for patients with PDAC were significantly disrupted during the first wave of the COVID-19 pandemic, with fewer patients receiving standard treatments. However, no significant impact on survival was discerned | ||
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a McKay, Siobhan C |e verfasserin |4 aut | |
| 700 | 1 | |a Halle-Smith, James |e verfasserin |4 aut | |
| 700 | 1 | |a Soane, Joshua |e verfasserin |4 aut | |
| 700 | 1 | |a Osei-Bordom, Daniel-Clement |e verfasserin |4 aut | |
| 700 | 1 | |a Goodburn, Lesley |e verfasserin |4 aut | |
| 700 | 1 | |a Magill, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Pinkney, Thomas |e verfasserin |4 aut | |
| 700 | 1 | |a Radhakrishna, Ganesh |e verfasserin |4 aut | |
| 700 | 1 | |a Valle, Juan W |e verfasserin |4 aut | |
| 700 | 1 | |a Corrie, Pippa |e verfasserin |4 aut | |
| 700 | 1 | |a Roberts, Keith J |e verfasserin |4 aut | |
| 700 | 0 | |a CONTACT Study Group |e verfasserin |4 aut | |
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