Alpha-ketoglutaric acid based polymeric particles for cutaneous wound healing
© 2023 Wiley Periodicals LLC..
Metabolites are not only involved in energy pathways but can also act as signaling molecules. Herein, we demonstrate that polyesters of alpha-ketoglutararte (paKG) can be generated by reacting aKG with aliphatic diols of different lengths, which release aKG in a sustained manner. paKG polymer-based microparticles generated via emulsion-evaporation technique lead to faster keratinocyte wound closures in a scratch assay test. Moreover, paKG microparticles also led to faster wound healing responses in an excisional wound model in live mice. Overall, this study shows that paKG MPs that release aKG in a sustained manner can be used to develop regenerative therapeutic responses.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:111 |
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| Enthalten in: |
Journal of biomedical materials research. Part A - 111(2023), 9 vom: 23. Sept., Seite 1372-1378 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Jaggarapu, Madhan M C S [VerfasserIn] |
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| Links: |
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| Themen: |
Alpha-ketoglutarate |
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| Anmerkungen: |
Date Completed 21.07.2023 Date Revised 04.10.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/jbm.a.37539 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM354564056 |
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| 520 | |a Metabolites are not only involved in energy pathways but can also act as signaling molecules. Herein, we demonstrate that polyesters of alpha-ketoglutararte (paKG) can be generated by reacting aKG with aliphatic diols of different lengths, which release aKG in a sustained manner. paKG polymer-based microparticles generated via emulsion-evaporation technique lead to faster keratinocyte wound closures in a scratch assay test. Moreover, paKG microparticles also led to faster wound healing responses in an excisional wound model in live mice. Overall, this study shows that paKG MPs that release aKG in a sustained manner can be used to develop regenerative therapeutic responses | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Yaron, Jordan R |e verfasserin |4 aut | |
| 700 | 1 | |a Mangal, Joslyn L |e verfasserin |4 aut | |
| 700 | 1 | |a Inamdar, Sahil |e verfasserin |4 aut | |
| 700 | 1 | |a Gosangi, Mallikarjun |e verfasserin |4 aut | |
| 700 | 1 | |a Rege, Kaushal |e verfasserin |4 aut | |
| 700 | 1 | |a Acharya, Abhinav P |e verfasserin |4 aut | |
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