Clinical Impression of Severity Index for Parkinson's Disease and Its Association to Health-Related Quality of Life
© 2022 International Parkinson and Movement Disorder Society..
Background: Clinical Impression of Severity Index for Parkinson's Disease (CISI-PD) is a simple tool that can easily be used in clinical practice. Few studies have investigated the relationship between health-related quality of life and the CISI-PD.
Objective: To analyze the association of CISI-PD scores with those of generic (EQ-5D-5L) and Parkinson's disease (PD) disease-specific (Parkinson's Disease Questionnaire-8 [PDQ-8]) health-related quality of life assessments.
Methods: Persons with idiopathic PD in the Swedish Parkinson's Disease registry with simultaneous registrations of CISI-PD and EQ-5D-5L and/or PDQ-8 were included. Correlations with EQ-5D dimensions were analyzed. The relationships between the CISI-PD, EQ-5D-5L, and PDQ-8 were estimated by linear mixed models with random intercept.
Results: In the Swedish Parkinson's Disease registry, 3511 registrations, among 2168 persons, fulfilled the inclusion criteria. The dimensions self-care, mobility, and usual activities correlated moderately with the CISI-PD (r s = 0.60, r s = 0.54, r s = 0.57). Weak correlations were found for anxiety/depression and pain/discomfort (r s = 0.39, r s = 0.29) (P values < 0.001). The fitted model included the CISI-PD, age, sex, and time since diagnosis. The CISI-PD had a statistically significant impact on the EQ-5D and PDQ-8 (P values < 0.001).
Conclusions: The CISI-PD provides a moderate correlation with the EQ-5D and could possibly be useful as a basis for defining health states in future health economic models and serving as outcomes in managed entry agreements. Nonetheless, the limitation of capturing nonmotor symptoms of the disease remains a shortcoming of clinical instruments, including the CISI-PD.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:10 |
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| Enthalten in: |
Movement disorders clinical practice - 10(2023), 3 vom: 23. März, Seite 392-398 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Norlin, Jenny M [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Revised 21.01.2024 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1002/mdc3.13649 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 500 | |a published: Electronic-eCollection | ||
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| 520 | |a © 2022 International Parkinson and Movement Disorder Society. | ||
| 520 | |a Background: Clinical Impression of Severity Index for Parkinson's Disease (CISI-PD) is a simple tool that can easily be used in clinical practice. Few studies have investigated the relationship between health-related quality of life and the CISI-PD | ||
| 520 | |a Objective: To analyze the association of CISI-PD scores with those of generic (EQ-5D-5L) and Parkinson's disease (PD) disease-specific (Parkinson's Disease Questionnaire-8 [PDQ-8]) health-related quality of life assessments | ||
| 520 | |a Methods: Persons with idiopathic PD in the Swedish Parkinson's Disease registry with simultaneous registrations of CISI-PD and EQ-5D-5L and/or PDQ-8 were included. Correlations with EQ-5D dimensions were analyzed. The relationships between the CISI-PD, EQ-5D-5L, and PDQ-8 were estimated by linear mixed models with random intercept | ||
| 520 | |a Results: In the Swedish Parkinson's Disease registry, 3511 registrations, among 2168 persons, fulfilled the inclusion criteria. The dimensions self-care, mobility, and usual activities correlated moderately with the CISI-PD (r s = 0.60, r s = 0.54, r s = 0.57). Weak correlations were found for anxiety/depression and pain/discomfort (r s = 0.39, r s = 0.29) (P values < 0.001). The fitted model included the CISI-PD, age, sex, and time since diagnosis. The CISI-PD had a statistically significant impact on the EQ-5D and PDQ-8 (P values < 0.001) | ||
| 520 | |a Conclusions: The CISI-PD provides a moderate correlation with the EQ-5D and could possibly be useful as a basis for defining health states in future health economic models and serving as outcomes in managed entry agreements. Nonetheless, the limitation of capturing nonmotor symptoms of the disease remains a shortcoming of clinical instruments, including the CISI-PD | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a CISI‐PD | |
| 650 | 4 | |a EQ‐5D | |
| 650 | 4 | |a PDQ‐8 | |
| 650 | 4 | |a Parkinson's disease | |
| 700 | 1 | |a Kellerborg, Klas |e verfasserin |4 aut | |
| 700 | 1 | |a Persson, Ulf |e verfasserin |4 aut | |
| 700 | 1 | |a Åström, Daniel Oudin |e verfasserin |4 aut | |
| 700 | 1 | |a Hagell, Peter |e verfasserin |4 aut | |
| 700 | 1 | |a Martinez-Martin, Pablo |e verfasserin |4 aut | |
| 700 | 1 | |a Odin, Per |e verfasserin |4 aut | |
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