SARS-CoV-2 Omicron variant shedding during respiratory activities
Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved..
OBJECTIVES: As the world transitions to COVID-19 endemicity, studies focusing on aerosol shedding of highly transmissible SARS-CoV-2 variants of concern (VOCs) are vital for the calibration of infection control measures against VOCs that are likely to circulate seasonally. This follow-up Gesundheit-II aerosol sampling study aims to compare the aerosol shedding patterns of Omicron VOC samples with pre-Omicron variants analyzed in our previous study.
DESIGN: Coarse and fine aerosol samples from 47 patients infected with SARS-CoV-2 were collected during various respiratory activities (passive breathing, talking, and singing) and analyzed using reverse transcription-quantitative polymerase chain reaction and virus culture.
RESULTS: Compared with patients infected with pre-Omicron variants, comparable SARS-CoV-2 RNA copy numbers were detectable in aerosol samples of patients infected with Omicron despite being fully vaccinated. Patients infected with Omicron also showed a slight increase in viral aerosol shedding during breathing activities and were more likely to have persistent aerosol shedding beyond 7 days after disease onset.
CONCLUSION: This follow-up study reaffirms the aerosol shedding properties of Omicron and should guide continued layering of public health interventions even in highly vaccinated populations.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:131 |
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| Enthalten in: |
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 131(2023) vom: 06. Juni, Seite 19-25 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Tan, Kai Sen [VerfasserIn] |
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| Links: |
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| Themen: |
Aerosol transmission |
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| Anmerkungen: |
Date Completed 05.05.2023 Date Revised 05.05.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ijid.2023.03.029 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM354536672 |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved. | ||
| 520 | |a OBJECTIVES: As the world transitions to COVID-19 endemicity, studies focusing on aerosol shedding of highly transmissible SARS-CoV-2 variants of concern (VOCs) are vital for the calibration of infection control measures against VOCs that are likely to circulate seasonally. This follow-up Gesundheit-II aerosol sampling study aims to compare the aerosol shedding patterns of Omicron VOC samples with pre-Omicron variants analyzed in our previous study | ||
| 520 | |a DESIGN: Coarse and fine aerosol samples from 47 patients infected with SARS-CoV-2 were collected during various respiratory activities (passive breathing, talking, and singing) and analyzed using reverse transcription-quantitative polymerase chain reaction and virus culture | ||
| 520 | |a RESULTS: Compared with patients infected with pre-Omicron variants, comparable SARS-CoV-2 RNA copy numbers were detectable in aerosol samples of patients infected with Omicron despite being fully vaccinated. Patients infected with Omicron also showed a slight increase in viral aerosol shedding during breathing activities and were more likely to have persistent aerosol shedding beyond 7 days after disease onset | ||
| 520 | |a CONCLUSION: This follow-up study reaffirms the aerosol shedding properties of Omicron and should guide continued layering of public health interventions even in highly vaccinated populations | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Aerosol transmission | |
| 650 | 4 | |a Airborne transmission | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Omicron variant of concern | |
| 650 | 4 | |a SARS-CoV-2 | |
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| 700 | 1 | |a Aw, Daryl Zheng Hao |e verfasserin |4 aut | |
| 700 | 1 | |a Nah, Yi Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Abdullah, Mohammed Ridzwan Bin |e verfasserin |4 aut | |
| 700 | 1 | |a Coleman, Kristen K |e verfasserin |4 aut | |
| 700 | 1 | |a Milton, Donald K |e verfasserin |4 aut | |
| 700 | 1 | |a Chu, Justin Jang Hann |e verfasserin |4 aut | |
| 700 | 1 | |a Chow, Vincent T K |e verfasserin |4 aut | |
| 700 | 1 | |a Tambyah, Paul Anantharajah |e verfasserin |4 aut | |
| 700 | 1 | |a Tham, Kwok Wai |e verfasserin |4 aut | |
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