CircRNA-mediated pathology : a new preliminary insight into the mechanism of type II cardio-renal syndrome
AIM: The aim of this research was to investigate the expression of peripheral blood circular RNA (circRNA) in patients with type II cardio-renal syndrome, uncover the potential function and possible mechanisms mediated by circRNAs, and ultimately provide gene target support for the treatment of type II cardio-renal syndrome.
METHODS: CircRNAs in the peripheral blood from five healthy individuals and 20 type II cardio-renal syndrome patients were collected for micro-array analysis. Another cohort study consisting of 12 normal cases and 15 type II cardiorenal syndrome patients was conducted to verify the chosen circRNA by quantitative real-time polymerase chain reaction.
RESULTS: A total of 2 884 circRNAs were found to be differentially expressed in the group of patients with type II cardio-renal syndrome. Of these, 1 989 were upregulated and 895 were downregulated. One circRNA was then selected as a candidate biomarker and further validated in the second cohort.
CONCLUSIONS: Differentially expressed mRNAs between patients with type II cardio-renal syndrome and healthy controls were enriched in two pathways, including haematopoietic cell lineage and cell adhesion molecules. CircRNA-mediated pathology is indispensable and plays an important role in the progress of type II cardio-renal syndrome. More importantly, hsa_cir_0001763 may be an important character in circRNA-mediated pathology.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:34 |
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| Enthalten in: |
Cardiovascular journal of Africa - 34(2023), 2 vom: 06. Mai, Seite 98-103 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wang, Huan [VerfasserIn] |
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| Links: |
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| Themen: |
63231-63-0 |
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| Anmerkungen: |
Date Completed 03.07.2023 Date Revised 21.11.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.5830/CVJA-2022-033 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM354523996 |
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| 100 | 1 | |a Wang, Huan |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a CircRNA-mediated pathology |b a new preliminary insight into the mechanism of type II cardio-renal syndrome |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Completed 03.07.2023 | ||
| 500 | |a Date Revised 21.11.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a AIM: The aim of this research was to investigate the expression of peripheral blood circular RNA (circRNA) in patients with type II cardio-renal syndrome, uncover the potential function and possible mechanisms mediated by circRNAs, and ultimately provide gene target support for the treatment of type II cardio-renal syndrome | ||
| 520 | |a METHODS: CircRNAs in the peripheral blood from five healthy individuals and 20 type II cardio-renal syndrome patients were collected for micro-array analysis. Another cohort study consisting of 12 normal cases and 15 type II cardiorenal syndrome patients was conducted to verify the chosen circRNA by quantitative real-time polymerase chain reaction | ||
| 520 | |a RESULTS: A total of 2 884 circRNAs were found to be differentially expressed in the group of patients with type II cardio-renal syndrome. Of these, 1 989 were upregulated and 895 were downregulated. One circRNA was then selected as a candidate biomarker and further validated in the second cohort | ||
| 520 | |a CONCLUSIONS: Differentially expressed mRNAs between patients with type II cardio-renal syndrome and healthy controls were enriched in two pathways, including haematopoietic cell lineage and cell adhesion molecules. CircRNA-mediated pathology is indispensable and plays an important role in the progress of type II cardio-renal syndrome. More importantly, hsa_cir_0001763 may be an important character in circRNA-mediated pathology | ||
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| 650 | 4 | |a quantitative real‐time polymerase chain reaction | |
| 650 | 4 | |a type II cardio‐renal syndrome | |
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| 700 | 1 | |a Shi, Jingjing |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Huaqin |e verfasserin |4 aut | |
| 700 | 1 | |a Qiu, Zhiling |e verfasserin |4 aut | |
| 700 | 1 | |a Geng, Yanting |e verfasserin |4 aut | |
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