Magnetic Ti3C2 MXene Nanosheets Prepared for Enrichment of Phosphopeptides
MXenes have received lots of attention since discovered and have been applied in various fields. In this work, Ti3C2-Fe3O4 composites with exposed non-modified Ti3C2 MXene nanosheets were designed and prepared by an in situ growth strategy and then applied in the enrichment of phosphopeptides. The two-dimensional composites could interact with the phosphopeptides through a metal oxide affinity chromatography mechanism provided by Ti-O and Fe-O bonds and a hydrophilic interaction chromatography mechanism by surface hydroxyl groups. This magnetic nanomaterial with a specific surface area of 66.1 m2·g-1 had high sensitivity to phosphopeptides (0.5 nmol·L-1) and high selectivity (1:1000 of the molar ratio of β-casein to bovine serum albumin). Non-fat milk was adopted as a real sample to preliminarily examine the applicability of the Ti3C2-Fe3O4-based protocol. Subsequently, Qingkailing injection, a kind of traditional Chinese medicine injection, was introduced to further explore the suitability of the nanocomposites for phosphopeptide enrichment from more complex matrices and satisfactory results were obtained.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
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| Enthalten in: |
ACS applied materials & interfaces - 15(2023), 13 vom: 05. Apr., Seite 16505-16514 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhang, Sen [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 07.04.2023 Date Revised 07.04.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1021/acsami.3c00848 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a MXenes have received lots of attention since discovered and have been applied in various fields. In this work, Ti3C2-Fe3O4 composites with exposed non-modified Ti3C2 MXene nanosheets were designed and prepared by an in situ growth strategy and then applied in the enrichment of phosphopeptides. The two-dimensional composites could interact with the phosphopeptides through a metal oxide affinity chromatography mechanism provided by Ti-O and Fe-O bonds and a hydrophilic interaction chromatography mechanism by surface hydroxyl groups. This magnetic nanomaterial with a specific surface area of 66.1 m2·g-1 had high sensitivity to phosphopeptides (0.5 nmol·L-1) and high selectivity (1:1000 of the molar ratio of β-casein to bovine serum albumin). Non-fat milk was adopted as a real sample to preliminarily examine the applicability of the Ti3C2-Fe3O4-based protocol. Subsequently, Qingkailing injection, a kind of traditional Chinese medicine injection, was introduced to further explore the suitability of the nanocomposites for phosphopeptide enrichment from more complex matrices and satisfactory results were obtained | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a MALDI-TOF MS | |
| 650 | 4 | |a Ti3C2 MXene | |
| 650 | 4 | |a hydrophilic interaction chromatography (HILIC) | |
| 650 | 4 | |a metal oxide affinity chromatography (MOAC) | |
| 650 | 4 | |a phosphopeptide enrichment | |
| 650 | 4 | |a traditional Chinese medicine injection (TCMI) | |
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| 700 | 1 | |a Gao, Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Qiao, Jun-Qin |e verfasserin |4 aut | |
| 700 | 1 | |a Lian, Hong-Zhen |e verfasserin |4 aut | |
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