Effects of oxycodone pharmacogenetics on postoperative analgesia and related clinical outcomes in children : a pilot prospective study
Background: Variability in the pharmacokinetics and pharmacodynamics of oxycodone in children undergoing surgery could be due to genetic polymorphisms. Materials & methods: The authors studied the association between clinical outcomes and pharmacogenes in children undergoing major surgery. A total of 89 children (35 undergoing pectus excavatum repair and 54 undergoing spinal fusion) were recruited. Results: OPRM1 SNP rs6902403 showed an association with maximum pain score and total morphine equivalent dose (p < 0.05). Other polymorphisms in OPRM1 SNP, PXR, COMT and ABCB1 were also shown to be associated with average morphine equivalent dose, length of hospital stay and maximum surgical pain (p < 0.05). Conclusion: This study demonstrates novel associations between the above pharmacogenes and oxycodone's pharmacokinetics as well as postoperative outcomes in children. Clinical trial registration: NCT03495388 (ClinicalTrials.gov).
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:24 |
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| Enthalten in: |
Pharmacogenomics - 24(2023), 4 vom: 22. März, Seite 187-197 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Aruldhas, Blessed W [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 29.03.2023 Date Revised 02.03.2024 published: Print-Electronic ClinicalTrials.gov: NCT03495388 Citation Status MEDLINE |
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| doi: |
10.2217/pgs-2022-0149 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
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| 100 | 1 | |a Aruldhas, Blessed W |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Effects of oxycodone pharmacogenetics on postoperative analgesia and related clinical outcomes in children |b a pilot prospective study |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a ClinicalTrials.gov: NCT03495388 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Background: Variability in the pharmacokinetics and pharmacodynamics of oxycodone in children undergoing surgery could be due to genetic polymorphisms. Materials & methods: The authors studied the association between clinical outcomes and pharmacogenes in children undergoing major surgery. A total of 89 children (35 undergoing pectus excavatum repair and 54 undergoing spinal fusion) were recruited. Results: OPRM1 SNP rs6902403 showed an association with maximum pain score and total morphine equivalent dose (p < 0.05). Other polymorphisms in OPRM1 SNP, PXR, COMT and ABCB1 were also shown to be associated with average morphine equivalent dose, length of hospital stay and maximum surgical pain (p < 0.05). Conclusion: This study demonstrates novel associations between the above pharmacogenes and oxycodone's pharmacokinetics as well as postoperative outcomes in children. Clinical trial registration: NCT03495388 (ClinicalTrials.gov) | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Packiasabapathy, Senthil |e verfasserin |4 aut | |
| 700 | 1 | |a Overholser, Brian R |e verfasserin |4 aut | |
| 700 | 1 | |a Raymond, Olivia |e verfasserin |4 aut | |
| 700 | 1 | |a Sivam, Sahana |e verfasserin |4 aut | |
| 700 | 1 | |a Sivam, Inesh |e verfasserin |4 aut | |
| 700 | 1 | |a Velu, Sanjana |e verfasserin |4 aut | |
| 700 | 1 | |a Montelibano, Antoinette |e verfasserin |4 aut | |
| 700 | 1 | |a Sadhasivam, Senthilkumar |e verfasserin |4 aut | |
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