Attachment of a trophoblastic spheroid onto endometrial epithelial cells predicts cumulative live birth in women aged 35 and older
Copyright © 2023 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved..
OBJECTIVE: To evaluate the attachment rate of a human embryonic stem cell-derived trophoblastic spheroid onto endometrial epithelial cells in predicting the cumulative live birth rate of an in vitro fertilization (IVF) cycle.
DESIGN: A prospective observational study.
SETTING: University hospital and research laboratory.
PATIENT(S): A total of 240 infertile women from 2017-2021.
INTERVENTION(S): Infertile women with regular cycles attending for IVF were recruited. An endometrial aspirate was collected from a natural cycle 1 month before IVF to determine the BAP-EB attachment rate.
MAIN OUTCOME MEASURE(S): Cumulative live birth rates from a stimulated cycle and its derived frozen embryo transfer cycles within 6 months of ovarian stimulation were obtained.
RESULT(S): The BAP-EB attachment rate in women who attained a cumulative live birth was similar to that in those who did not. When women were stratified by age into <35 years and ≥35 years, the BAP-EB attachment rate was significantly higher only in women aged ≥35 years having a live birth when compared with those in the same age group without a live birth. Receiver operating characteristic curve analysis of BAP-EB attachment rate in predicting cumulative live birth showed the areas under the curve of 0.559 (95% confidence interval [CI], 0.479-0.639), 0.448 (95% CI, 0.310-0.585), and 0.613 (95% CI, 0.517-0.710) for all ages, an age of <35 years, and an age of ≥35 years, respectively.
CONCLUSION(S): The BAP-EB attachment rate offers only a very modest prediction of the cumulative live birth rate in women aged ≥35 years undergoing IVF.
CLINICAL TRIAL REGISTRATION NUMBER: NCT02713854 (https://clinicaltrials.gov/ct2/show/NCT02713854; Date of registration, March 21, 2016; date of enrollment of the first subject, August 1, 2017).
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:120 |
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| Enthalten in: |
Fertility and sterility - 120(2023), 2 vom: 10. Aug., Seite 268-276 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lee, Yin Lau [VerfasserIn] |
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| Links: |
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| Themen: |
Cumulative live birth |
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| Anmerkungen: |
Date Completed 01.08.2023 Date Revised 01.08.2023 published: Print-Electronic ClinicalTrials.gov: NCT02713854 Citation Status MEDLINE |
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| doi: |
10.1016/j.fertnstert.2023.03.013 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
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| 100 | 1 | |a Lee, Yin Lau |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Attachment of a trophoblastic spheroid onto endometrial epithelial cells predicts cumulative live birth in women aged 35 and older |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Completed 01.08.2023 | ||
| 500 | |a Date Revised 01.08.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a ClinicalTrials.gov: NCT02713854 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a OBJECTIVE: To evaluate the attachment rate of a human embryonic stem cell-derived trophoblastic spheroid onto endometrial epithelial cells in predicting the cumulative live birth rate of an in vitro fertilization (IVF) cycle | ||
| 520 | |a DESIGN: A prospective observational study | ||
| 520 | |a SETTING: University hospital and research laboratory | ||
| 520 | |a PATIENT(S): A total of 240 infertile women from 2017-2021 | ||
| 520 | |a INTERVENTION(S): Infertile women with regular cycles attending for IVF were recruited. An endometrial aspirate was collected from a natural cycle 1 month before IVF to determine the BAP-EB attachment rate | ||
| 520 | |a MAIN OUTCOME MEASURE(S): Cumulative live birth rates from a stimulated cycle and its derived frozen embryo transfer cycles within 6 months of ovarian stimulation were obtained | ||
| 520 | |a RESULT(S): The BAP-EB attachment rate in women who attained a cumulative live birth was similar to that in those who did not. When women were stratified by age into <35 years and ≥35 years, the BAP-EB attachment rate was significantly higher only in women aged ≥35 years having a live birth when compared with those in the same age group without a live birth. Receiver operating characteristic curve analysis of BAP-EB attachment rate in predicting cumulative live birth showed the areas under the curve of 0.559 (95% confidence interval [CI], 0.479-0.639), 0.448 (95% CI, 0.310-0.585), and 0.613 (95% CI, 0.517-0.710) for all ages, an age of <35 years, and an age of ≥35 years, respectively | ||
| 520 | |a CONCLUSION(S): The BAP-EB attachment rate offers only a very modest prediction of the cumulative live birth rate in women aged ≥35 years undergoing IVF | ||
| 520 | |a CLINICAL TRIAL REGISTRATION NUMBER: NCT02713854 (https://clinicaltrials.gov/ct2/show/NCT02713854; Date of registration, March 21, 2016; date of enrollment of the first subject, August 1, 2017) | ||
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a In vitro fertilization | |
| 650 | 4 | |a cumulative live birth | |
| 650 | 4 | |a embryo attachment | |
| 650 | 4 | |a endometrial receptivity | |
| 650 | 4 | |a trophoblastic spheroid | |
| 700 | 1 | |a Ruan, Hanzhang |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Kai Chuen |e verfasserin |4 aut | |
| 700 | 1 | |a Fong, Sze Wan |e verfasserin |4 aut | |
| 700 | 1 | |a Yue, Chaomin |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Andy Chun Hang |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Kai Fai |e verfasserin |4 aut | |
| 700 | 1 | |a Lam, Mei Ting |e verfasserin |4 aut | |
| 700 | 1 | |a Yeung, William Shu Biu |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Raymond Hang Wun |e verfasserin |4 aut | |
| 700 | 1 | |a Ng, Ernest Hung Yu |e verfasserin |4 aut | |
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