Acute myeloid leukemia : novel mutations and their clinical implications
AJBR Copyright © 2023..
Acute myeloid leukemia (AML) is a heterogenous and challenging hematological malignancy with suboptimal outcomes. The implications of advanced technologies in the genetic characterization of AML have enhanced the understanding of individualized patient risk, which has also led to the development of new therapeutic strategies. A comprehensive study of novel mutations is essential to moderate the complicacies in patient management and achieve optimal outcomes in AML. In this review, we summarized the clinical relevance of important novel mutations, including TET2, ETV6, SATB1, EZH2, PTPN11, and U2AF1, which impact the prognosis of AML. TET2 mutation can lead to DNA hypermethylation, and gene fusion, and mutation in ETV6 disrupts hematopoietic transcription machinery, SATB1 downregulation aggravates the disease, and EZH2 mutation confers resistance to chemotherapy. PTPN11 mutation influences the RAS-MAPK signaling pathway, and U2AF1 alters the splicing of downstream mRNA. The systemic influence of these mutations has adverse consequences. Therefore, extensive research on novel mutations and their mechanism of action in the pathogenesis of AML is vital. This study lays out the perspective of expanding the apprehension about AML and novel drug targets. The combination of advanced genetic techniques, risk stratification, ongoing improvements, and innovations in treatment strategy will undoubtedly lead to improved survival outcomes in AML.
Medienart: |
Artikel |
---|
Erscheinungsjahr: |
2023 |
---|---|
Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
---|---|
Enthalten in: |
American journal of blood research - 13(2023), 1 vom: 23., Seite 12-27 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Makkar, Harshita [VerfasserIn] |
---|
Themen: |
Acute myeloid leukemia |
---|
Anmerkungen: |
Date Revised 21.03.2023 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
---|
Förderinstitution / Projekttitel: |
|
---|
PPN (Katalog-ID): |
NLM354428535 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM354428535 | ||
003 | DE-627 | ||
005 | 20231226210124.0 | ||
007 | tu | ||
008 | 231226s2023 xx ||||| 00| ||eng c | ||
028 | 5 | 2 | |a pubmed24n1181.xml |
035 | |a (DE-627)NLM354428535 | ||
035 | |a (NLM)36937458 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Makkar, Harshita |e verfasserin |4 aut | |
245 | 1 | 0 | |a Acute myeloid leukemia |b novel mutations and their clinical implications |
264 | 1 | |c 2023 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
338 | |a Band |b nc |2 rdacarrier | ||
500 | |a Date Revised 21.03.2023 | ||
500 | |a published: Electronic-eCollection | ||
500 | |a Citation Status PubMed-not-MEDLINE | ||
520 | |a AJBR Copyright © 2023. | ||
520 | |a Acute myeloid leukemia (AML) is a heterogenous and challenging hematological malignancy with suboptimal outcomes. The implications of advanced technologies in the genetic characterization of AML have enhanced the understanding of individualized patient risk, which has also led to the development of new therapeutic strategies. A comprehensive study of novel mutations is essential to moderate the complicacies in patient management and achieve optimal outcomes in AML. In this review, we summarized the clinical relevance of important novel mutations, including TET2, ETV6, SATB1, EZH2, PTPN11, and U2AF1, which impact the prognosis of AML. TET2 mutation can lead to DNA hypermethylation, and gene fusion, and mutation in ETV6 disrupts hematopoietic transcription machinery, SATB1 downregulation aggravates the disease, and EZH2 mutation confers resistance to chemotherapy. PTPN11 mutation influences the RAS-MAPK signaling pathway, and U2AF1 alters the splicing of downstream mRNA. The systemic influence of these mutations has adverse consequences. Therefore, extensive research on novel mutations and their mechanism of action in the pathogenesis of AML is vital. This study lays out the perspective of expanding the apprehension about AML and novel drug targets. The combination of advanced genetic techniques, risk stratification, ongoing improvements, and innovations in treatment strategy will undoubtedly lead to improved survival outcomes in AML | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Review | |
650 | 4 | |a Acute myeloid leukemia | |
650 | 4 | |a genetic mutations | |
650 | 4 | |a next-generation sequencing | |
650 | 4 | |a risk-stratification | |
650 | 4 | |a survival | |
650 | 4 | |a targeted therapy | |
700 | 1 | |a Majhi, Ravi Kumar |e verfasserin |4 aut | |
700 | 1 | |a Goel, Harsh |e verfasserin |4 aut | |
700 | 1 | |a Gupta, Aditya Kumar |e verfasserin |4 aut | |
700 | 1 | |a Chopra, Anita |e verfasserin |4 aut | |
700 | 1 | |a Tanwar, Pranay |e verfasserin |4 aut | |
700 | 1 | |a Seth, Rachna |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t American journal of blood research |d 2011 |g 13(2023), 1 vom: 23., Seite 12-27 |w (DE-627)NLM216338336 |x 2160-1992 |7 nnns |
773 | 1 | 8 | |g volume:13 |g year:2023 |g number:1 |g day:23 |g pages:12-27 |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 13 |j 2023 |e 1 |b 23 |h 12-27 |