Fundus topographical distribution patterns of ocular toxoplasmosis
© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ..
BACKGROUND: To establish topographic maps and determine fundus distribution patterns of ocular toxoplasmosis (OT) lesions.
METHODS: In this retrospective study, patients who presented with OT to ophthalmology clinics from four countries (Argentina, Turkey, UK, USA) were included. Size, shape and location of primary (1°)/recurrent (2°) and active/inactive lesions were converted into a two-dimensional retinal chart by a retinal drawing software. A final contour map of the merged image charts was then created using a custom Matlab programme. Descriptive analyses were performed.
RESULTS: 984 lesions in 514 eyes of 464 subjects (53% women) were included. Mean area of all 1° and 2° lesions was 5.96±12.26 and 5.21±12.77 mm2, respectively. For the subset group lesions (eyes with both 1° and 2° lesions), 1° lesions were significantly larger than 2° lesions (5.52±6.04 mm2 vs 4.09±8.90 mm2, p=0.038). Mean distances from foveola to 1° and 2° lesion centres were 6336±4267 and 5763±3491 µm, respectively. The majority of lesions were found in temporal quadrant (p<0.001). Maximum overlap of all lesions was at 278 µm inferotemporal to foveola.
CONCLUSION: The 1° lesions were larger than 2° lesions. The 2° lesions were not significantly closer to fovea than 1° lesions. Temporal quadrant and macular region were found to be densely affected underlining the vision threatening nature of the disease.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:108 |
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| Enthalten in: |
The British journal of ophthalmology - 108(2024), 4 vom: 20. März, Seite 530-535 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hasanreisoglu, Murat [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Completed 22.03.2024 Date Revised 22.03.2024 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1136/bjo-2022-322747 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM354370979 |
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| 100 | 1 | |a Hasanreisoglu, Murat |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Fundus topographical distribution patterns of ocular toxoplasmosis |
| 264 | 1 | |c 2024 | |
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| 500 | |a Date Revised 22.03.2024 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ. | ||
| 520 | |a BACKGROUND: To establish topographic maps and determine fundus distribution patterns of ocular toxoplasmosis (OT) lesions | ||
| 520 | |a METHODS: In this retrospective study, patients who presented with OT to ophthalmology clinics from four countries (Argentina, Turkey, UK, USA) were included. Size, shape and location of primary (1°)/recurrent (2°) and active/inactive lesions were converted into a two-dimensional retinal chart by a retinal drawing software. A final contour map of the merged image charts was then created using a custom Matlab programme. Descriptive analyses were performed | ||
| 520 | |a RESULTS: 984 lesions in 514 eyes of 464 subjects (53% women) were included. Mean area of all 1° and 2° lesions was 5.96±12.26 and 5.21±12.77 mm2, respectively. For the subset group lesions (eyes with both 1° and 2° lesions), 1° lesions were significantly larger than 2° lesions (5.52±6.04 mm2 vs 4.09±8.90 mm2, p=0.038). Mean distances from foveola to 1° and 2° lesion centres were 6336±4267 and 5763±3491 µm, respectively. The majority of lesions were found in temporal quadrant (p<0.001). Maximum overlap of all lesions was at 278 µm inferotemporal to foveola | ||
| 520 | |a CONCLUSION: The 1° lesions were larger than 2° lesions. The 2° lesions were not significantly closer to fovea than 1° lesions. Temporal quadrant and macular region were found to be densely affected underlining the vision threatening nature of the disease | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Choroid | |
| 650 | 4 | |a Imaging | |
| 650 | 4 | |a Infection | |
| 650 | 4 | |a Inflammation | |
| 650 | 4 | |a Retina | |
| 700 | 1 | |a Halim, Muhammad Sohail |e verfasserin |4 aut | |
| 700 | 1 | |a Cakar Ozdal, Pinar |e verfasserin |4 aut | |
| 700 | 1 | |a Ormaechea, Maria Soledad |e verfasserin |4 aut | |
| 700 | 1 | |a Kesim, Cem |e verfasserin |4 aut | |
| 700 | 1 | |a Ozdemir, Huseyin Baran |e verfasserin |4 aut | |
| 700 | 1 | |a Uludag, Gunay |e verfasserin |4 aut | |
| 700 | 1 | |a Sredar, Nripun |e verfasserin |4 aut | |
| 700 | 1 | |a Cankurtaran, Mahmut |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Xiaoxuan |e verfasserin |4 aut | |
| 700 | 1 | |a Denniston, Alastair Keith |e verfasserin |4 aut | |
| 700 | 1 | |a Rudzinski, Marcelo N |e verfasserin |4 aut | |
| 700 | 1 | |a Colombero, Daniel N |e verfasserin |4 aut | |
| 700 | 1 | |a Schlaen, Bernardo Ariel |e verfasserin |4 aut | |
| 700 | 1 | |a Keane, Pearse Andrew |e verfasserin |4 aut | |
| 700 | 1 | |a Pavesio, Carlos |e verfasserin |4 aut | |
| 700 | 1 | |a Nguyen, Quan Dong |e verfasserin |4 aut | |
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