Recurrence rate and survival implications of surgical margins in patients with acral melanoma. Is a wide margin necessary?
Copyright: © 2023 Permanyer..
INTRODUCTION: Appropriate size of resection margins in acral melanoma is not clearly established.
OBJECTIVE: To investigate whether narrow-margin excision is appropriate for thick acral melanoma.
METHODS: Three-hundred and six patients with acral melanoma were examined. Factors associated with recurrence and survival were analyzed according to surgical margin size (1 to 2 cm and > 2 cm).
RESULTS: Out of 306 patients, 183 were women (59.8%). Median Breslow thickness was 6 mm; 224 cases (73.2%) were ulcerated, 154 patients (50.3%) had clinical stage III disease, while 137 were at stage II (44.8%) and 15 at stage IV (4.9%). All cases had negative margins, with a median of 31.5 mm. A Breslow thickness of 7 mm (p = 0.001) and clinical stage III (p = 0.031) were associated with recurrence; the factors associated with survival were Breslow index (p = 0.047), ulceration (p = 0.003), advanced clinical stage (p < 0.001), and use of adjuvant therapy (p = 0.003).
CONCLUSION: A resection margin of 1 to 2 cm did not affect tumor recurrence or survival in patients with acral melanoma.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:159 |
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| Enthalten in: |
Gaceta medica de Mexico - 159(2023), 1 vom: 15., Seite 38-43 |
| Sprache: |
Englisch |
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| Weiterer Titel: |
Tasa de recurrencia e implicación del margen quirúrgico en la supervivencia del paciente con melanoma acral. ¿Es necesario un margen amplio? |
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| Beteiligte Personen: |
Lino-Silva, Leonardo S [VerfasserIn] |
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| Links: |
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| Themen: |
Acral melanoma |
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| Anmerkungen: |
Date Completed 21.03.2023 Date Revised 13.12.2023 published: Print Citation Status MEDLINE |
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| doi: |
10.24875/GMM.M22000734 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM354359630 |
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| 245 | 1 | 0 | |a Recurrence rate and survival implications of surgical margins in patients with acral melanoma. Is a wide margin necessary? |
| 246 | 3 | 3 | |a Tasa de recurrencia e implicación del margen quirúrgico en la supervivencia del paciente con melanoma acral. ¿Es necesario un margen amplio? |
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| 500 | |a Date Completed 21.03.2023 | ||
| 500 | |a Date Revised 13.12.2023 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright: © 2023 Permanyer. | ||
| 520 | |a INTRODUCTION: Appropriate size of resection margins in acral melanoma is not clearly established | ||
| 520 | |a OBJECTIVE: To investigate whether narrow-margin excision is appropriate for thick acral melanoma | ||
| 520 | |a METHODS: Three-hundred and six patients with acral melanoma were examined. Factors associated with recurrence and survival were analyzed according to surgical margin size (1 to 2 cm and > 2 cm) | ||
| 520 | |a RESULTS: Out of 306 patients, 183 were women (59.8%). Median Breslow thickness was 6 mm; 224 cases (73.2%) were ulcerated, 154 patients (50.3%) had clinical stage III disease, while 137 were at stage II (44.8%) and 15 at stage IV (4.9%). All cases had negative margins, with a median of 31.5 mm. A Breslow thickness of 7 mm (p = 0.001) and clinical stage III (p = 0.031) were associated with recurrence; the factors associated with survival were Breslow index (p = 0.047), ulceration (p = 0.003), advanced clinical stage (p < 0.001), and use of adjuvant therapy (p = 0.003) | ||
| 520 | |a CONCLUSION: A resection margin of 1 to 2 cm did not affect tumor recurrence or survival in patients with acral melanoma | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Acral melanoma | |
| 650 | 4 | |a Margen quirúrgico | |
| 650 | 4 | |a Melanoma acral | |
| 650 | 4 | |a Supervivencia | |
| 650 | 4 | |a Surgical margin | |
| 650 | 4 | |a Survival | |
| 700 | 1 | |a Hernández-Romero, Raúl |e verfasserin |4 aut | |
| 700 | 1 | |a García-Herrera, Juan S |e verfasserin |4 aut | |
| 700 | 1 | |a Zepeda-Najar, César |e verfasserin |4 aut | |
| 700 | 1 | |a Salcedo-Hernández, Rosa A |e verfasserin |4 aut | |
| 700 | 1 | |a León-Takahashi, Alberto M |e verfasserin |4 aut | |
| 700 | 1 | |a Escobar-Jiménez, Marín G |e verfasserin |4 aut | |
| 700 | 1 | |a Herrera-Gómez, Ángel |e verfasserin |4 aut | |
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