Assessment of anti-psoriatic activity of bakuchiol-loaded solid lipid nanoparticles-based gel : design, characterization, and mechanistic insight via NF-kB signaling pathway
© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature..
The aim of the current study is to evaluate the anti-psoriatic potential of bakuchiol (Bak) loaded solid lipid nanoparticles (SLNs) via modulating inflammatory and oxidative pathways. Bak-loaded SLNs were prepared using hot homogenization method and characterized by various spectroscopic techniques. Bak-SLNs suspension was formulated into gel using Carbopol. Different in vivo assays were executed to explore the role of inflammatory markers and oxidative enzymes in psoriasis. DLS (dynamic light scattering) analysis showed suitable particle size, zeta potential, and polydispersity index (PDI) of developed formulation. TEM (transmission electron microscopy) reveal the spherical shape of Bak-SLNs particles. The release studies confirmed the sustained release of Bak-SLNs-based gel. UV-B-induced psoriatic Wistar rat model showed significant anti-psoriatic effect of Bak via regulating inflammatory markers (NF-kB, IL-6, IL-4, and IL-10) and levels of anti-oxidant enzymes, superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and glutathione-S-transferase (GST). Furthermore, RT-qPCR analysis confirms that Bak downregulates the expression of inflammatory markers, while histology and immunohistology results also confirm the anti-psoriatic effect of Bak. The study indicates that Bak-loaded SLNs-based gel significantly downregulates the level of cytokines and interleukins involve in NF-kB signaling cascade; hence, it can prove to be a novel therapeutic approach to cure psoriasis.
| Errataetall: |
RetractionIn: Naunyn Schmiedebergs Arch Pharmacol. 2023 Nov 21;:. - PMID 37987798 |
|---|---|
| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:396 |
|---|---|
| Enthalten in: |
Naunyn-Schmiedeberg's archives of pharmacology - 396(2023), 9 vom: 08. Sept., Seite 2105-2125 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Attri, Shivani [VerfasserIn] |
|---|
| Links: |
|---|
| Anmerkungen: |
Date Completed 09.08.2023 Date Revised 21.11.2023 published: Print-Electronic RetractionIn: Naunyn Schmiedebergs Arch Pharmacol. 2023 Nov 21;:. - PMID 37987798 Citation Status MEDLINE |
|---|
| doi: |
10.1007/s00210-023-02445-1 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM354347594 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM354347594 | ||
| 003 | DE-627 | ||
| 005 | 20231226062025.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00210-023-02445-1 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1181.xml |
| 035 | |a (DE-627)NLM354347594 | ||
| 035 | |a (NLM)36929274 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Attri, Shivani |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Assessment of anti-psoriatic activity of bakuchiol-loaded solid lipid nanoparticles-based gel |b design, characterization, and mechanistic insight via NF-kB signaling pathway |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 09.08.2023 | ||
| 500 | |a Date Revised 21.11.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a RetractionIn: Naunyn Schmiedebergs Arch Pharmacol. 2023 Nov 21;:. - PMID 37987798 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. | ||
| 520 | |a The aim of the current study is to evaluate the anti-psoriatic potential of bakuchiol (Bak) loaded solid lipid nanoparticles (SLNs) via modulating inflammatory and oxidative pathways. Bak-loaded SLNs were prepared using hot homogenization method and characterized by various spectroscopic techniques. Bak-SLNs suspension was formulated into gel using Carbopol. Different in vivo assays were executed to explore the role of inflammatory markers and oxidative enzymes in psoriasis. DLS (dynamic light scattering) analysis showed suitable particle size, zeta potential, and polydispersity index (PDI) of developed formulation. TEM (transmission electron microscopy) reveal the spherical shape of Bak-SLNs particles. The release studies confirmed the sustained release of Bak-SLNs-based gel. UV-B-induced psoriatic Wistar rat model showed significant anti-psoriatic effect of Bak via regulating inflammatory markers (NF-kB, IL-6, IL-4, and IL-10) and levels of anti-oxidant enzymes, superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and glutathione-S-transferase (GST). Furthermore, RT-qPCR analysis confirms that Bak downregulates the expression of inflammatory markers, while histology and immunohistology results also confirm the anti-psoriatic effect of Bak. The study indicates that Bak-loaded SLNs-based gel significantly downregulates the level of cytokines and interleukins involve in NF-kB signaling cascade; hence, it can prove to be a novel therapeutic approach to cure psoriasis | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Retracted Publication | |
| 650 | 4 | |a Bakuchiol | |
| 650 | 4 | |a Inflammation | |
| 650 | 4 | |a Psoralea corylifolia | |
| 650 | 4 | |a Psoriasis | |
| 650 | 4 | |a Topical therapy | |
| 650 | 7 | |a Lipid Nanoparticles |2 NLM | |
| 650 | 7 | |a NF-kappa B |2 NLM | |
| 650 | 7 | |a bakuchiol |2 NLM | |
| 650 | 7 | |a OT12HJU3AR |2 NLM | |
| 650 | 7 | |a Glutathione |2 NLM | |
| 650 | 7 | |a GAN16C9B8O |2 NLM | |
| 650 | 7 | |a Drug Carriers |2 NLM | |
| 700 | 1 | |a Kumar, Ajay |e verfasserin |4 aut | |
| 700 | 1 | |a Kaur, Kirandeep |e verfasserin |4 aut | |
| 700 | 1 | |a Kaur, Prabhjot |e verfasserin |4 aut | |
| 700 | 1 | |a Punj, Sanha |e verfasserin |4 aut | |
| 700 | 1 | |a Bedi, Neena |e verfasserin |4 aut | |
| 700 | 1 | |a Tuli, Hardeep Singh |e verfasserin |4 aut | |
| 700 | 1 | |a Arora, Saroj |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Naunyn-Schmiedeberg's archives of pharmacology |d 1972 |g 396(2023), 9 vom: 08. Sept., Seite 2105-2125 |w (DE-627)NLM000008354 |x 1432-1912 |7 nnns |
| 773 | 1 | 8 | |g volume:396 |g year:2023 |g number:9 |g day:08 |g month:09 |g pages:2105-2125 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/s00210-023-02445-1 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 396 |j 2023 |e 9 |b 08 |c 09 |h 2105-2125 | ||