Pseudotyped Viruses for Phlebovirus
© 2023. The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd..
Rift Valley fever virus (RVFV) is a member of the Phlebovirus genus, one of the 20 genera in the Phenuiviridae family. RVFV causes disease in animals and humans and is transmitted by sandflies or ticks. However, research into RVFV is limited by the requirement for biosafety level 3 (BSL-3) containment. Pseudotyped virus overcomes this limitation as it can be handled in a BSL-2 environment. Pseudotyped RVFV possesses an identical envelope protein structure to that of the authentic virus, simulating the same process of receptor binding and membrane fusion to host cells. Pseudotyped phleboviruses are therefore useful tools to study the infection mechanism of these viruses and for the screening of inhibitory drugs and the development of therapeutic monoclonal antibodies.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:1407 |
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| Enthalten in: |
Advances in experimental medicine and biology - 1407(2023) vom: 15., Seite 253-264 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wu, Jiajing [VerfasserIn] |
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| Links: |
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| Themen: |
In vitro |
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| Anmerkungen: |
Date Completed 20.03.2023 Date Revised 20.03.2023 published: Print Citation Status MEDLINE |
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| doi: |
10.1007/978-981-99-0113-5_13 |
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| funding: |
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| 520 | |a Rift Valley fever virus (RVFV) is a member of the Phlebovirus genus, one of the 20 genera in the Phenuiviridae family. RVFV causes disease in animals and humans and is transmitted by sandflies or ticks. However, research into RVFV is limited by the requirement for biosafety level 3 (BSL-3) containment. Pseudotyped virus overcomes this limitation as it can be handled in a BSL-2 environment. Pseudotyped RVFV possesses an identical envelope protein structure to that of the authentic virus, simulating the same process of receptor binding and membrane fusion to host cells. Pseudotyped phleboviruses are therefore useful tools to study the infection mechanism of these viruses and for the screening of inhibitory drugs and the development of therapeutic monoclonal antibodies | ||
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