Disproportionation-Inspired Construction of Highly Functionalized Bicyclo[3.2.1]octanes
The formation of one unavoidable byproduct in traditional disproportionation reactions limits their applications in synthesis. Inspired by convergent disproportionation, we develop an iodine-induced cyclization and oxidation of allylic alcohols to produce highly functionalized bicyclo[3.2.1]octanes through creation of six new bonds. Guided by the mechanism, we elaborated a variety of other bicyclo[3.2.1]octanes bearing distinct groups with presynthesized dienes and enones as the starting materials. This work provides a divergent access to bicyclo[3.2.1]octane frameworks.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:25 |
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| Enthalten in: |
Organic letters - 25(2023), 11 vom: 24. März, Seite 1878-1882 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Liu, Heng [VerfasserIn] |
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| Anmerkungen: |
Date Completed 24.03.2023 Date Revised 24.03.2023 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1021/acs.orglett.3c00397 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM354223224 |
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| 520 | |a The formation of one unavoidable byproduct in traditional disproportionation reactions limits their applications in synthesis. Inspired by convergent disproportionation, we develop an iodine-induced cyclization and oxidation of allylic alcohols to produce highly functionalized bicyclo[3.2.1]octanes through creation of six new bonds. Guided by the mechanism, we elaborated a variety of other bicyclo[3.2.1]octanes bearing distinct groups with presynthesized dienes and enones as the starting materials. This work provides a divergent access to bicyclo[3.2.1]octane frameworks | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Min, Xiang-Ting |e verfasserin |4 aut | |
| 700 | 1 | |a Mei, Yong-Kang |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Shao-Han |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Gong |e verfasserin |4 aut | |
| 700 | 1 | |a Hu, Yan-Cheng |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Qing-An |e verfasserin |4 aut | |
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