Early shoulder-girdle MRI findings in severe COVID-19-related intensive care unit-acquired weakness : a prospective cohort study
© 2023. The Author(s), under exclusive licence to European Society of Radiology..
OBJECTIVE: To describe clinical and early shoulder-girdle MR imaging findings in severe COVID-19-related intensive care unit-acquired weakness (ICU-AW) after ICU discharge.
METHODS: A single-center prospective cohort study of all consecutive patients with COVID-19-related ICU-AW from November 2020 to June 2021. All patients underwent similar clinical evaluations and shoulder-girdle MRI within the first month and then 3 months (± 1 month) after ICU discharge.
RESULTS: We included 25 patients (14 males; mean [SD] age 62.4 [12.5]). Within the first month after ICU discharge, all patients showed severe proximal predominant bilateral muscular weakness (mean Medical Research Council total score = 46.5/60 [10.1]) associated with bilateral, peripheral muscular edema-like MRI signals of the shoulder girdle in 23/25 (92%) patients. At 3 months, 21/25 (84%) patients showed complete or quasi-complete resolution of proximal muscular weakness (mean Medical Research Council total score > 48/60) and 23/25 (92%) complete resolution of MRI signals of the shoulder girdle, but 12/20 (60%) patients experienced shoulder pain and/or shoulder dysfunction.
CONCLUSIONS: Early shoulder-girdle MRI findings in COVID-19-related ICU-AW included muscular edema-like peripheral signal intensities, without fatty muscle involution or muscle necrosis, with favorable evolution at 3 months. Precocious MRI can help clinicians distinguish critical illness myopathy from alternative, more severe diagnoses and can be useful in the care of patients discharged from intensive care with ICU-AW.
KEY POINTS: • We describe the clinical and shoulder-girdle MRI findings of COVID-19-related severe intensive care unit-acquired weakness. • This information can be used by clinicians to achieve a nearly specific diagnosis, distinguish alternative diagnoses, assess functional prognosis, and select the more appropriate health care rehabilitation and shoulder impairment treatment.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:33 |
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| Enthalten in: |
European radiology - 33(2023), 7 vom: 01. Juli, Seite 4994-5006 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Daste, Camille [VerfasserIn] |
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| Links: |
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| Themen: |
COVID-19 |
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| Anmerkungen: |
Date Completed 26.06.2023 Date Revised 26.06.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s00330-023-09468-5 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM35418525X |
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| 100 | 1 | |a Daste, Camille |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Early shoulder-girdle MRI findings in severe COVID-19-related intensive care unit-acquired weakness |b a prospective cohort study |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 500 | |a Date Completed 26.06.2023 | ||
| 500 | |a Date Revised 26.06.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023. The Author(s), under exclusive licence to European Society of Radiology. | ||
| 520 | |a OBJECTIVE: To describe clinical and early shoulder-girdle MR imaging findings in severe COVID-19-related intensive care unit-acquired weakness (ICU-AW) after ICU discharge | ||
| 520 | |a METHODS: A single-center prospective cohort study of all consecutive patients with COVID-19-related ICU-AW from November 2020 to June 2021. All patients underwent similar clinical evaluations and shoulder-girdle MRI within the first month and then 3 months (± 1 month) after ICU discharge | ||
| 520 | |a RESULTS: We included 25 patients (14 males; mean [SD] age 62.4 [12.5]). Within the first month after ICU discharge, all patients showed severe proximal predominant bilateral muscular weakness (mean Medical Research Council total score = 46.5/60 [10.1]) associated with bilateral, peripheral muscular edema-like MRI signals of the shoulder girdle in 23/25 (92%) patients. At 3 months, 21/25 (84%) patients showed complete or quasi-complete resolution of proximal muscular weakness (mean Medical Research Council total score > 48/60) and 23/25 (92%) complete resolution of MRI signals of the shoulder girdle, but 12/20 (60%) patients experienced shoulder pain and/or shoulder dysfunction | ||
| 520 | |a CONCLUSIONS: Early shoulder-girdle MRI findings in COVID-19-related ICU-AW included muscular edema-like peripheral signal intensities, without fatty muscle involution or muscle necrosis, with favorable evolution at 3 months. Precocious MRI can help clinicians distinguish critical illness myopathy from alternative, more severe diagnoses and can be useful in the care of patients discharged from intensive care with ICU-AW | ||
| 520 | |a KEY POINTS: • We describe the clinical and shoulder-girdle MRI findings of COVID-19-related severe intensive care unit-acquired weakness. • This information can be used by clinicians to achieve a nearly specific diagnosis, distinguish alternative diagnoses, assess functional prognosis, and select the more appropriate health care rehabilitation and shoulder impairment treatment | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Intensive care unit | |
| 650 | 4 | |a Magnetic resonance imaging | |
| 650 | 4 | |a Muscle weakness | |
| 650 | 4 | |a Shoulder | |
| 700 | 1 | |a Mihoubi, Fadila |e verfasserin |4 aut | |
| 700 | 1 | |a Roren, Alexandra |e verfasserin |4 aut | |
| 700 | 1 | |a Dumitrache, Alina |e verfasserin |4 aut | |
| 700 | 1 | |a Carlier, Nicolas |e verfasserin |4 aut | |
| 700 | 1 | |a Benghanem, Sarah |e verfasserin |4 aut | |
| 700 | 1 | |a Ruttimann, Aude |e verfasserin |4 aut | |
| 700 | 1 | |a Mira, Jean-Paul |e verfasserin |4 aut | |
| 700 | 1 | |a Pène, Frédéric |e verfasserin |4 aut | |
| 700 | 1 | |a Roche, Nicolas |e verfasserin |4 aut | |
| 700 | 1 | |a Seror, Paul |e verfasserin |4 aut | |
| 700 | 1 | |a Nguyen, Christelle |e verfasserin |4 aut | |
| 700 | 1 | |a Rannou, François |e verfasserin |4 aut | |
| 700 | 1 | |a Drapé, Jean-Luc |e verfasserin |4 aut | |
| 700 | 1 | |a Lefèvre-Colau, Marie-Martine |e verfasserin |4 aut | |
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