Sex differences in clinical characteristics of migraine and its burden : a population-based study
© 2023 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology..
BACKGROUND AND PURPOSE: Understanding migraine in a sex-specific manner is crucial for improving clinical care, diagnosis and therapy for both females and males. Here, data on sex differences are provided in the presentation of migraine in a large European-based population cohort, which is representative of the general population.
METHODS: A population-based study of 62,672 Danish blood donors (both present and previous donors), of whom 12,658 had migraine, was performed. All participants completed a 105-item diagnostic migraine questionnaire sent via an electronic mailing system (e-Boks) between May 2020 and August 2020. The questionnaire allowed for correct diagnosis of migraine according to the International Classification of Headache Disorders, third edition.
RESULTS: The migraine questionnaire was in-cohort validated and had a positive predictive value of 97% for any migraine, a specificity of 93% and a sensitivity of 93%. There were 9184 females (mean age 45.1 years) and 3434 males (mean age 48.0 years). The 3-month prevalence of migraine without aura was 11% in females and 3.59% in males. The 3-month prevalence of migraine with aura was 1.72% in females and 1.58% in males. In females, the age-related 3-month prevalence of migraine without aura increased markedly during childbearing age. In males, migraine both with and without aura showed less age variation. Females had a higher frequency of migraine attacks (odds ratio [OR] 1.22) but a lower frequency of non-migraine headaches (OR = 0.35). Females also had a greater intensity of pain, more unilateral and pulsatile pain, and exacerbation by physical activity (OR = 1.40-1.49) as well as more associated symptoms (OR = 1.26-1.98). Females carried 79% of the total migraine disease burden, which was almost exclusively driven by migraine without aura (77%), whilst there was no sex difference in the disease burden of migraine with aura.
CONCLUSION: Females have more severe disease, resulting in a much higher migraine disease burden than indicated by prevalence alone.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:30 |
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| Enthalten in: |
European journal of neurology - 30(2023), 6 vom: 15. Juni, Seite 1774-1784 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Chalmer, Mona Ameri [VerfasserIn] |
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| Links: |
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| Themen: |
Blood donors |
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| Anmerkungen: |
Date Completed 08.05.2023 Date Revised 18.05.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/ene.15778 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM354107321 |
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| 100 | 1 | |a Chalmer, Mona Ameri |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Sex differences in clinical characteristics of migraine and its burden |b a population-based study |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Completed 08.05.2023 | ||
| 500 | |a Date Revised 18.05.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology. | ||
| 520 | |a BACKGROUND AND PURPOSE: Understanding migraine in a sex-specific manner is crucial for improving clinical care, diagnosis and therapy for both females and males. Here, data on sex differences are provided in the presentation of migraine in a large European-based population cohort, which is representative of the general population | ||
| 520 | |a METHODS: A population-based study of 62,672 Danish blood donors (both present and previous donors), of whom 12,658 had migraine, was performed. All participants completed a 105-item diagnostic migraine questionnaire sent via an electronic mailing system (e-Boks) between May 2020 and August 2020. The questionnaire allowed for correct diagnosis of migraine according to the International Classification of Headache Disorders, third edition | ||
| 520 | |a RESULTS: The migraine questionnaire was in-cohort validated and had a positive predictive value of 97% for any migraine, a specificity of 93% and a sensitivity of 93%. There were 9184 females (mean age 45.1 years) and 3434 males (mean age 48.0 years). The 3-month prevalence of migraine without aura was 11% in females and 3.59% in males. The 3-month prevalence of migraine with aura was 1.72% in females and 1.58% in males. In females, the age-related 3-month prevalence of migraine without aura increased markedly during childbearing age. In males, migraine both with and without aura showed less age variation. Females had a higher frequency of migraine attacks (odds ratio [OR] 1.22) but a lower frequency of non-migraine headaches (OR = 0.35). Females also had a greater intensity of pain, more unilateral and pulsatile pain, and exacerbation by physical activity (OR = 1.40-1.49) as well as more associated symptoms (OR = 1.26-1.98). Females carried 79% of the total migraine disease burden, which was almost exclusively driven by migraine without aura (77%), whilst there was no sex difference in the disease burden of migraine with aura | ||
| 520 | |a CONCLUSION: Females have more severe disease, resulting in a much higher migraine disease burden than indicated by prevalence alone | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a blood donors | |
| 650 | 4 | |a burden | |
| 650 | 4 | |a migraine | |
| 650 | 4 | |a population-based study | |
| 650 | 4 | |a sex differences | |
| 650 | 4 | |a sex stratification | |
| 700 | 1 | |a Kogelman, Lisette J A |e verfasserin |4 aut | |
| 700 | 1 | |a Callesen, Ida |e verfasserin |4 aut | |
| 700 | 1 | |a Christensen, Charlotte Grønvold |e verfasserin |4 aut | |
| 700 | 1 | |a Techlo, Tanya Ramdal |e verfasserin |4 aut | |
| 700 | 1 | |a Møller, Peter L |e verfasserin |4 aut | |
| 700 | 1 | |a Davidsson, Olafur B |e verfasserin |4 aut | |
| 700 | 1 | |a Olofsson, Isa A |e verfasserin |4 aut | |
| 700 | 1 | |a Schwinn, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Mikkelsen, Susan |e verfasserin |4 aut | |
| 700 | 1 | |a Dinh, Khoa Manh |e verfasserin |4 aut | |
| 700 | 1 | |a Nielsen, Kaspar |e verfasserin |4 aut | |
| 700 | 1 | |a Topholm, Mie |e verfasserin |4 aut | |
| 700 | 1 | |a Erikstrup, Christian |e verfasserin |4 aut | |
| 700 | 1 | |a Ostrowski, Sisse Rye |e verfasserin |4 aut | |
| 700 | 1 | |a Pedersen, Ole Birger |e verfasserin |4 aut | |
| 700 | 0 | |a DBDS Genomic Consortium |e verfasserin |4 aut | |
| 700 | 1 | |a Hjalgrim, Henrik |e verfasserin |4 aut | |
| 700 | 1 | |a Banasik, Karina |e verfasserin |4 aut | |
| 700 | 1 | |a Burgdorf, Kristoffer S |e verfasserin |4 aut | |
| 700 | 1 | |a Nyegaard, Mette |e verfasserin |4 aut | |
| 700 | 1 | |a Olesen, Jes |e verfasserin |4 aut | |
| 700 | 1 | |a Hansen, Thomas Folkmann |e verfasserin |4 aut | |
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