State of the art in epitope mapping and opportunities in COVID-19
© 2023 The Authors..
The understanding of any disease calls for studying specific biological structures called epitopes. One important tool recently drawing attention and proving efficiency in both diagnosis and vaccine development is epitope mapping. Several techniques have been developed with the urge to provide precise epitope mapping for use in designing sensitive diagnostic tools and developing rpitope-based vaccines (EBVs) as well as therapeutics. In this review, we will discuss the state of the art in epitope mapping with a special emphasis on accomplishments and opportunities in combating COVID-19. These comprise SARS-CoV-2 variant analysis versus the currently available immune-based diagnostic tools and vaccines, immunological profile-based patient stratification, and finally, exploring novel epitope targets for potential prophylactic, therapeutic or diagnostic agents for COVID-19.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:16 |
|---|---|
| Enthalten in: |
Future science OA - 16(2023), 3-06 vom: 14. Feb., Seite FSO832 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Hamed, Samira M [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Diagnostic tools |
|---|
| Anmerkungen: |
Date Revised 13.03.2023 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
|---|
| doi: |
10.2144/fsoa-2022-0048 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM354036416 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM354036416 | ||
| 003 | DE-627 | ||
| 005 | 20231226061345.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.2144/fsoa-2022-0048 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1180.xml |
| 035 | |a (DE-627)NLM354036416 | ||
| 035 | |a (NLM)36897962 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Hamed, Samira M |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a State of the art in epitope mapping and opportunities in COVID-19 |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 13.03.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © 2023 The Authors. | ||
| 520 | |a The understanding of any disease calls for studying specific biological structures called epitopes. One important tool recently drawing attention and proving efficiency in both diagnosis and vaccine development is epitope mapping. Several techniques have been developed with the urge to provide precise epitope mapping for use in designing sensitive diagnostic tools and developing rpitope-based vaccines (EBVs) as well as therapeutics. In this review, we will discuss the state of the art in epitope mapping with a special emphasis on accomplishments and opportunities in combating COVID-19. These comprise SARS-CoV-2 variant analysis versus the currently available immune-based diagnostic tools and vaccines, immunological profile-based patient stratification, and finally, exploring novel epitope targets for potential prophylactic, therapeutic or diagnostic agents for COVID-19 | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a SARS-CoV-2 | |
| 650 | 4 | |a diagnostic tools | |
| 650 | 4 | |a epitope mapping | |
| 650 | 4 | |a epitope-based vaccines | |
| 650 | 4 | |a host-pathogen interface | |
| 700 | 1 | |a Sakr, Masarra M |e verfasserin |4 aut | |
| 700 | 1 | |a El-Housseiny, Ghadir S |e verfasserin |4 aut | |
| 700 | 1 | |a Wasfi, Reham |e verfasserin |4 aut | |
| 700 | 1 | |a Aboshanab, Khaled M |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Future science OA |d 2015 |g 16(2023), 3-06 vom: 14. Feb., Seite FSO832 |w (DE-627)NLM255260911 |x 2056-5623 |7 nnns |
| 773 | 1 | 8 | |g volume:16 |g year:2023 |g number:3-06 |g day:14 |g month:02 |g pages:FSO832 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.2144/fsoa-2022-0048 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 16 |j 2023 |e 3-06 |b 14 |c 02 |h FSO832 | ||