Optic radiations representing different eccentricities age differently
© 2023 The Authors. Human Brain Mapping published by Wiley Periodicals LLC..
The neural pathways that carry information from the foveal, macular, and peripheral visual fields have distinct biological properties. The optic radiations (OR) carry foveal and peripheral information from the thalamus to the primary visual cortex (V1) through adjacent but separate pathways in the white matter. Here, we perform white matter tractometry using pyAFQ on a large sample of diffusion MRI (dMRI) data from subjects with healthy vision in the U.K. Biobank dataset (UKBB; N = 5382; age 45-81). We use pyAFQ to characterize white matter tissue properties in parts of the OR that transmit information about the foveal, macular, and peripheral visual fields, and to characterize the changes in these tissue properties with age. We find that (1) independent of age there is higher fractional anisotropy, lower mean diffusivity, and higher mean kurtosis in the foveal and macular OR than in peripheral OR, consistent with denser, more organized nerve fiber populations in foveal/parafoveal pathways, and (2) age is associated with increased diffusivity and decreased anisotropy and kurtosis, consistent with decreased density and tissue organization with aging. However, anisotropy in foveal OR decreases faster with age than in peripheral OR, while diffusivity increases faster in peripheral OR, suggesting foveal/peri-foveal OR and peripheral OR differ in how they age.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:44 |
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| Enthalten in: |
Human brain mapping - 44(2023), 8 vom: 01. Juni, Seite 3123-3135 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kruper, John [VerfasserIn] |
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| Links: |
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| Themen: |
Aging |
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| Anmerkungen: |
Date Completed 12.05.2023 Date Revised 01.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/hbm.26267 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM354025570 |
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| 520 | |a © 2023 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. | ||
| 520 | |a The neural pathways that carry information from the foveal, macular, and peripheral visual fields have distinct biological properties. The optic radiations (OR) carry foveal and peripheral information from the thalamus to the primary visual cortex (V1) through adjacent but separate pathways in the white matter. Here, we perform white matter tractometry using pyAFQ on a large sample of diffusion MRI (dMRI) data from subjects with healthy vision in the U.K. Biobank dataset (UKBB; N = 5382; age 45-81). We use pyAFQ to characterize white matter tissue properties in parts of the OR that transmit information about the foveal, macular, and peripheral visual fields, and to characterize the changes in these tissue properties with age. We find that (1) independent of age there is higher fractional anisotropy, lower mean diffusivity, and higher mean kurtosis in the foveal and macular OR than in peripheral OR, consistent with denser, more organized nerve fiber populations in foveal/parafoveal pathways, and (2) age is associated with increased diffusivity and decreased anisotropy and kurtosis, consistent with decreased density and tissue organization with aging. However, anisotropy in foveal OR decreases faster with age than in peripheral OR, while diffusivity increases faster in peripheral OR, suggesting foveal/peri-foveal OR and peripheral OR differ in how they age | ||
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| 650 | 4 | |a U.K. biobank | |
| 650 | 4 | |a aging | |
| 650 | 4 | |a diffusion MRI | |
| 650 | 4 | |a optic radiation | |
| 650 | 4 | |a retinal mapping | |
| 650 | 4 | |a tractography | |
| 650 | 4 | |a tractometry | |
| 650 | 4 | |a visual system | |
| 700 | 1 | |a Benson, Noah C |e verfasserin |4 aut | |
| 700 | 1 | |a Caffarra, Sendy |e verfasserin |4 aut | |
| 700 | 1 | |a Owen, Julia |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Yue |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Aaron Y |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Cecilia S |e verfasserin |4 aut | |
| 700 | 1 | |a Yeatman, Jason D |e verfasserin |4 aut | |
| 700 | 1 | |a Rokem, Ariel |e verfasserin |4 aut | |
| 700 | 0 | |a UK Biobank Eye and Vision Consortium |e verfasserin |4 aut | |
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