Patient characteristics in sepsis-related deaths : prevalence of advanced frailty, comorbidity, and age in a Norwegian hospital trust
© 2023. The Author(s)..
OBJECTIVE: To examine the prevalence of advanced frailty, comorbidity, and age among sepsis-related deaths in an adult hospital population.
METHODS: Retrospective chart reviews of deceased adults within a Norwegian hospital trust, with a diagnosis of infection, over 2 years (2018-2019). The likelihood of sepsis-related death was evaluated by clinicians as sepsis-related, possibly sepsis-related, or not sepsis-related.
RESULTS: Of 633 hospital deaths, 179 (28%) were sepsis-related, and 136 (21%) were possibly sepsis-related. Among these 315 patients whose deaths were sepsis-related or possibly sepsis-related, close to three in four patients (73%) were either 85 years or older, living with severe frailty (Clinical Frailty Scale, CFS, score of 7 or more), or an end-stage condition prior to the admission. Among the remaining 27%, 15% were either 80-84 years old, living with frailty corresponding to a CFS score of 6, or severe comorbidity, defined as 5 points or more on the Charlson Comorbidity Index (CCI). The last 12% constituted the presumably healthiest cluster, but in this group as well, the majority died with limitations of care due to their premorbid functional status and/ or comorbidity. Findings remained stable if the population was limited to sepsis-related deaths on clinicians' reviews or those fulfilling the Sepsis-3 criteria.
CONCLUSIONS: Advanced frailty, comorbidity, and age were predominant in hospital fatalities where infection contributed to death, with or without sepsis. This is of importance when considering sepsis-related mortality in similar populations, the applicability of study results to everyday clinical work, and future study designs.
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:51 |
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| Enthalten in: |
Infection - 51(2023), 4 vom: 09. Aug., Seite 1103-1115 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Torvik, Marianne Ask [VerfasserIn] |
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Date Completed 19.07.2023 Date Revised 20.07.2023 published: Print-Electronic ErratumIn: Infection. 2023 May 12;:. - PMID 37173607 Citation Status MEDLINE |
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| doi: |
10.1007/s15010-023-02013-y |
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| funding: |
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NLM354004522 |
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| 100 | 1 | |a Torvik, Marianne Ask |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Patient characteristics in sepsis-related deaths |b prevalence of advanced frailty, comorbidity, and age in a Norwegian hospital trust |
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| 500 | |a Date Completed 19.07.2023 | ||
| 500 | |a Date Revised 20.07.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a ErratumIn: Infection. 2023 May 12;:. - PMID 37173607 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023. The Author(s). | ||
| 520 | |a OBJECTIVE: To examine the prevalence of advanced frailty, comorbidity, and age among sepsis-related deaths in an adult hospital population | ||
| 520 | |a METHODS: Retrospective chart reviews of deceased adults within a Norwegian hospital trust, with a diagnosis of infection, over 2 years (2018-2019). The likelihood of sepsis-related death was evaluated by clinicians as sepsis-related, possibly sepsis-related, or not sepsis-related | ||
| 520 | |a RESULTS: Of 633 hospital deaths, 179 (28%) were sepsis-related, and 136 (21%) were possibly sepsis-related. Among these 315 patients whose deaths were sepsis-related or possibly sepsis-related, close to three in four patients (73%) were either 85 years or older, living with severe frailty (Clinical Frailty Scale, CFS, score of 7 or more), or an end-stage condition prior to the admission. Among the remaining 27%, 15% were either 80-84 years old, living with frailty corresponding to a CFS score of 6, or severe comorbidity, defined as 5 points or more on the Charlson Comorbidity Index (CCI). The last 12% constituted the presumably healthiest cluster, but in this group as well, the majority died with limitations of care due to their premorbid functional status and/ or comorbidity. Findings remained stable if the population was limited to sepsis-related deaths on clinicians' reviews or those fulfilling the Sepsis-3 criteria | ||
| 520 | |a CONCLUSIONS: Advanced frailty, comorbidity, and age were predominant in hospital fatalities where infection contributed to death, with or without sepsis. This is of importance when considering sepsis-related mortality in similar populations, the applicability of study results to everyday clinical work, and future study designs | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Comorbidity | |
| 650 | 4 | |a Frailty | |
| 650 | 4 | |a Mortality | |
| 650 | 4 | |a Sepsis | |
| 700 | 1 | |a Nymo, Stig Haugset |e verfasserin |4 aut | |
| 700 | 1 | |a Nymo, Ståle Haugset |e verfasserin |4 aut | |
| 700 | 1 | |a Bjørnsen, Lars Petter |e verfasserin |4 aut | |
| 700 | 1 | |a Kvarenes, Hanne Winge |e verfasserin |4 aut | |
| 700 | 1 | |a Ofstad, Eirik Hugaas |e verfasserin |4 aut | |
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