Short-Term Effects of Genicular Artery Embolization on Symptoms and Bone Marrow Abnormalities in Patients with Refractory Knee Osteoarthritis
Copyright © 2023 SIR. Published by Elsevier Inc. All rights reserved..
PURPOSE: To evaluate the short-term outcomes of genicular artery embolization (GAE) for knee osteoarthritis (OA) with and without bone marrow lesion (BML) and/or subchondral insufficiency fracture of the knee (SIFK).
MATERIALS AND METHODS: This single-institution prospective observational pilot study analyzed 24 knees in 22 patients with mild to moderate knee OA, including 8 knees without BML, 13 knees with BML, and 3 knees with both BML and SIFK. The area and volume of BMLs on magnetic resonance images were measured before and after GAE. Baseline and postoperative pain and physical function were assessed using the visual analog scale (VAS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC).
RESULTS: GAE significantly reduced the BML area and volume 3 months after embolization in the knees with BML (both P < .0005). GAE significantly decreased the VAS scores at 3 and 6 months after embolization in patients without BML (both P = .04) and those with BML (both P = .01). GAE also lowered the WOMAC scores 3 months after embolization in patients without and with BML (P = .02 and P = .0002, respectively). However, GAE did not significantly alter the BML area and volume (both P = .25), VAS scores (P = 1.00), and WOMAC scores (P = .08) in patients with BML and SIFK at 3 months after GAE.
CONCLUSIONS: This observational pilot study suggested that GAE effectively reduces the BML area and volume and improves pain and physical function in patients with knee OA accompanied by BML but is inefficacious in those with both BML and SIFK.
| Errataetall: |
CommentIn: J Vasc Interv Radiol. 2023 Oct;34(10):1843-1844. - PMID 37364733 |
|---|---|
| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:34 |
|---|---|
| Enthalten in: |
Journal of vascular and interventional radiology : JVIR - 34(2023), 7 vom: 01. Juli, Seite 1126-1134.e2 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Wang, Bow [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Journal Article |
|---|
| Anmerkungen: |
Date Completed 30.06.2023 Date Revised 29.09.2023 published: Print-Electronic CommentIn: J Vasc Interv Radiol. 2023 Oct;34(10):1843-1844. - PMID 37364733 Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.jvir.2023.02.028 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM353951595 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM353951595 | ||
| 003 | DE-627 | ||
| 005 | 20231226061153.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.jvir.2023.02.028 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1179.xml |
| 035 | |a (DE-627)NLM353951595 | ||
| 035 | |a (NLM)36889435 | ||
| 035 | |a (PII)S1051-0443(23)00202-6 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Wang, Bow |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Short-Term Effects of Genicular Artery Embolization on Symptoms and Bone Marrow Abnormalities in Patients with Refractory Knee Osteoarthritis |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 30.06.2023 | ||
| 500 | |a Date Revised 29.09.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: J Vasc Interv Radiol. 2023 Oct;34(10):1843-1844. - PMID 37364733 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 SIR. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a PURPOSE: To evaluate the short-term outcomes of genicular artery embolization (GAE) for knee osteoarthritis (OA) with and without bone marrow lesion (BML) and/or subchondral insufficiency fracture of the knee (SIFK) | ||
| 520 | |a MATERIALS AND METHODS: This single-institution prospective observational pilot study analyzed 24 knees in 22 patients with mild to moderate knee OA, including 8 knees without BML, 13 knees with BML, and 3 knees with both BML and SIFK. The area and volume of BMLs on magnetic resonance images were measured before and after GAE. Baseline and postoperative pain and physical function were assessed using the visual analog scale (VAS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) | ||
| 520 | |a RESULTS: GAE significantly reduced the BML area and volume 3 months after embolization in the knees with BML (both P < .0005). GAE significantly decreased the VAS scores at 3 and 6 months after embolization in patients without BML (both P = .04) and those with BML (both P = .01). GAE also lowered the WOMAC scores 3 months after embolization in patients without and with BML (P = .02 and P = .0002, respectively). However, GAE did not significantly alter the BML area and volume (both P = .25), VAS scores (P = 1.00), and WOMAC scores (P = .08) in patients with BML and SIFK at 3 months after GAE | ||
| 520 | |a CONCLUSIONS: This observational pilot study suggested that GAE effectively reduces the BML area and volume and improves pain and physical function in patients with knee OA accompanied by BML but is inefficacious in those with both BML and SIFK | ||
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 700 | 1 | |a Tai, Ta-Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Liang, Keng-Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Chien-Kuo |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Yi-Sheng |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Ming-Tung |e verfasserin |4 aut | |
| 700 | 1 | |a Chang, Chih-Wei |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of vascular and interventional radiology : JVIR |d 1997 |g 34(2023), 7 vom: 01. Juli, Seite 1126-1134.e2 |w (DE-627)NLM012603120 |x 1535-7732 |7 nnns |
| 773 | 1 | 8 | |g volume:34 |g year:2023 |g number:7 |g day:01 |g month:07 |g pages:1126-1134.e2 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.jvir.2023.02.028 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 34 |j 2023 |e 7 |b 01 |c 07 |h 1126-1134.e2 | ||