Aortic Arch Calcification in Ungated Lung Computed Tomography Scans as Predictors of Atherosclerotic Cardiovascular Disease : Methodology and Reproducibility in a Multi-Ethnic Study of Atherosclerosis
Background: Aortic arch calcium (AAC), which is frequently detected on ungated lung computed tomography (CT) due to a large field of view, can serve as a marker of subclinical atherosclerotic burden. Our study sought to validate novel cardiac screening metrics of subclinical atherosclerosis by evaluating the inter- and intra-observer reproducibility of AAC measurements with ungated lung CT.
Methods: The authors randomly selected 100 ungated lung CT scans from the Multi-Ethnic Study of Atherosclerosis cohort. A Bland-Altman plot analysis was used to test inter- and intra-reader reproducibility, after measuring the total arch calcium score and arch calcium volume.
Results: The intra-reader reproducibility for the total arch calcium score and arch calcium volume in all subjects was excellent at 99% and 97%, respectively. The inter-reader reproducibility for the total arch calcium score and volume in all subjects was similarly excellent at 97% and 96%, respectively.
Conclusions: The high reproducibility of ungated lung CT suggests a potential new method of stratifying the atherosclerotic cardiovascular disease risk among patients undergoing lung CT without requiring additional scanning. This methodology helps promote routine reporting of AAC and coronary artery calcium based on millions of ungated CT images acquired for lung screening purposes.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:28 |
|---|---|
| Enthalten in: |
Journal of coronary artery disease - 28(2022), 4 vom: 03., Seite 57-64 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Golub, Ilana [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Atherosclerotic cardiovascular disease |
|---|
| Anmerkungen: |
Date Revised 10.02.2024 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
|---|
| doi: |
10.7793/jcad.28.22-00004 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM353807761 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM353807761 | ||
| 003 | DE-627 | ||
| 005 | 20240210232508.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.7793/jcad.28.22-00004 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1286.xml |
| 035 | |a (DE-627)NLM353807761 | ||
| 035 | |a (NLM)36874906 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Golub, Ilana |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Aortic Arch Calcification in Ungated Lung Computed Tomography Scans as Predictors of Atherosclerotic Cardiovascular Disease |b Methodology and Reproducibility in a Multi-Ethnic Study of Atherosclerosis |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 10.02.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Background: Aortic arch calcium (AAC), which is frequently detected on ungated lung computed tomography (CT) due to a large field of view, can serve as a marker of subclinical atherosclerotic burden. Our study sought to validate novel cardiac screening metrics of subclinical atherosclerosis by evaluating the inter- and intra-observer reproducibility of AAC measurements with ungated lung CT | ||
| 520 | |a Methods: The authors randomly selected 100 ungated lung CT scans from the Multi-Ethnic Study of Atherosclerosis cohort. A Bland-Altman plot analysis was used to test inter- and intra-reader reproducibility, after measuring the total arch calcium score and arch calcium volume | ||
| 520 | |a Results: The intra-reader reproducibility for the total arch calcium score and arch calcium volume in all subjects was excellent at 99% and 97%, respectively. The inter-reader reproducibility for the total arch calcium score and volume in all subjects was similarly excellent at 97% and 96%, respectively | ||
| 520 | |a Conclusions: The high reproducibility of ungated lung CT suggests a potential new method of stratifying the atherosclerotic cardiovascular disease risk among patients undergoing lung CT without requiring additional scanning. This methodology helps promote routine reporting of AAC and coronary artery calcium based on millions of ungated CT images acquired for lung screening purposes | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a MESA | |
| 650 | 4 | |a atherosclerotic cardiovascular disease | |
| 650 | 4 | |a computed tomography | |
| 650 | 4 | |a coronary artery calcium scoring | |
| 650 | 4 | |a extracoronary calcification | |
| 700 | 1 | |a Sheppard, John P |e verfasserin |4 aut | |
| 700 | 1 | |a Lakshmanan, Suvasini |e verfasserin |4 aut | |
| 700 | 1 | |a Dahal, Suraj |e verfasserin |4 aut | |
| 700 | 1 | |a Kinninger, April |e verfasserin |4 aut | |
| 700 | 1 | |a Allison, Matthew |e verfasserin |4 aut | |
| 700 | 1 | |a Barr, Graham |e verfasserin |4 aut | |
| 700 | 1 | |a McClelland, Robyn |e verfasserin |4 aut | |
| 700 | 1 | |a Blaha, Michael J |e verfasserin |4 aut | |
| 700 | 1 | |a Roy, Sion K |e verfasserin |4 aut | |
| 700 | 1 | |a Budoff, Matthew J |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of coronary artery disease |d 2022 |g 28(2022), 4 vom: 03., Seite 57-64 |w (DE-627)NLM353807753 |x 2434-2173 |7 nnns |
| 773 | 1 | 8 | |g volume:28 |g year:2022 |g number:4 |g day:03 |g pages:57-64 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.7793/jcad.28.22-00004 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 28 |j 2022 |e 4 |b 03 |h 57-64 | ||