Population-Based Mini-Mental State Examination Norms in Adults of Mexican Heritage in the Cameron County Hispanic Cohort
BACKGROUND: Accurately identifying cognitive changes in Mexican American (MA) adults using the Mini-Mental State Examination (MMSE) requires knowledge of population-based norms for the MMSE, a scale which has widespread use in research settings.
OBJECTIVE: To describe the distribution of MMSE scores in a large cohort of MA adults, assess the impact of MMSE requirements on their clinical trial eligibility, and explore which factors are most strongly associated with their MMSE scores.
METHODS: Visits between 2004-2021 in the Cameron County Hispanic Cohort were analyzed. Eligible participants were ≥18 years old and of Mexican descent. MMSE distributions before and after stratification by age and years of education (YOE) were assessed, as was the proportion of trial-aged (50-85- year-old) participants with MMSE <24, a minimum MMSE cutoff most frequently used in Alzheimer's disease (AD) clinical trials. As a secondary analysis, random forest models were constructed to estimate the relative association of the MMSE with potentially relevant variables.
RESULTS: The mean age of the sample set (n = 3,404) was 44.4 (SD, 16.0) years old and 64.5% female. Median MMSE was 28 (IQR, 28-29). The percentage of trial-aged participants (n = 1,267) with MMSE <24 was 18.6% overall and 54.3% among the subset with 0-4 YOE (n = 230). The five variables most associated with the MMSE in the study sample were education, age, exercise, C-reactive protein, and anxiety.
CONCLUSION: The minimum MMSE cutoffs in most phase III prodromal-to-mild AD trials would exclude a significant proportion of trial-aged participants in this MA cohort, including over half of those with 0-4 YOE.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:92 |
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| Enthalten in: |
Journal of Alzheimer's disease : JAD - 92(2023), 4 vom: 28., Seite 1323-1339 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Bukhbinder, Avram S [VerfasserIn] |
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| Links: |
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| Themen: |
Cameron County Hispanic Cohort |
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| Anmerkungen: |
Date Completed 29.04.2023 Date Revised 23.05.2023 published: Print Citation Status MEDLINE |
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| doi: |
10.3233/JAD-220934 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM353786543 |
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| 100 | 1 | |a Bukhbinder, Avram S |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Population-Based Mini-Mental State Examination Norms in Adults of Mexican Heritage in the Cameron County Hispanic Cohort |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Revised 23.05.2023 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Accurately identifying cognitive changes in Mexican American (MA) adults using the Mini-Mental State Examination (MMSE) requires knowledge of population-based norms for the MMSE, a scale which has widespread use in research settings | ||
| 520 | |a OBJECTIVE: To describe the distribution of MMSE scores in a large cohort of MA adults, assess the impact of MMSE requirements on their clinical trial eligibility, and explore which factors are most strongly associated with their MMSE scores | ||
| 520 | |a METHODS: Visits between 2004-2021 in the Cameron County Hispanic Cohort were analyzed. Eligible participants were ≥18 years old and of Mexican descent. MMSE distributions before and after stratification by age and years of education (YOE) were assessed, as was the proportion of trial-aged (50-85- year-old) participants with MMSE <24, a minimum MMSE cutoff most frequently used in Alzheimer's disease (AD) clinical trials. As a secondary analysis, random forest models were constructed to estimate the relative association of the MMSE with potentially relevant variables | ||
| 520 | |a RESULTS: The mean age of the sample set (n = 3,404) was 44.4 (SD, 16.0) years old and 64.5% female. Median MMSE was 28 (IQR, 28-29). The percentage of trial-aged participants (n = 1,267) with MMSE <24 was 18.6% overall and 54.3% among the subset with 0-4 YOE (n = 230). The five variables most associated with the MMSE in the study sample were education, age, exercise, C-reactive protein, and anxiety | ||
| 520 | |a CONCLUSION: The minimum MMSE cutoffs in most phase III prodromal-to-mild AD trials would exclude a significant proportion of trial-aged participants in this MA cohort, including over half of those with 0-4 YOE | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Cameron County Hispanic Cohort | |
| 650 | 4 | |a Mexican Americans | |
| 650 | 4 | |a Mini-Mental State Examination | |
| 650 | 4 | |a clinical trial eligibility | |
| 700 | 1 | |a Hinojosa, Miriam |e verfasserin |4 aut | |
| 700 | 1 | |a Harris, Kristofer |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Xiaojin |e verfasserin |4 aut | |
| 700 | 1 | |a Farrell, Christine M |e verfasserin |4 aut | |
| 700 | 1 | |a Shyer, Madison |e verfasserin |4 aut | |
| 700 | 1 | |a Goodwin, Nathan |e verfasserin |4 aut | |
| 700 | 1 | |a Anjum, Sahar |e verfasserin |4 aut | |
| 700 | 1 | |a Hasan, Omar |e verfasserin |4 aut | |
| 700 | 1 | |a Cooper, Susan |e verfasserin |4 aut | |
| 700 | 1 | |a Sciba, Lois |e verfasserin |4 aut | |
| 700 | 1 | |a Vargas, Amanda Falk |e verfasserin |4 aut | |
| 700 | 1 | |a Hunter, David H |e verfasserin |4 aut | |
| 700 | 1 | |a Ortiz, Guadalupe J |e verfasserin |4 aut | |
| 700 | 1 | |a Chung, Karen |e verfasserin |4 aut | |
| 700 | 1 | |a Cui, Licong |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Guo-Qiang |e verfasserin |4 aut | |
| 700 | 1 | |a Fisher-Hoch, Susan P |e verfasserin |4 aut | |
| 700 | 1 | |a McCormick, Joseph B |e verfasserin |4 aut | |
| 700 | 1 | |a Schulz, Paul E |e verfasserin |4 aut | |
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