Safety of COVID-19 Vaccines among Patients with Type 2 Diabetes Mellitus : Real-World Data Analysis
BACKGROUND: Little is known about the adverse events (AEs) associated with coronavirus disease 2019 (COVID-19) vaccination in patients with type 2 diabetes mellitus (T2DM).
METHODS: This study used vaccine AE reporting system data to investigate severe AEs among vaccinated patients with T2DM. A natural language processing algorithm was applied to identify people with and without diabetes. After 1:3 matching, we collected data for 6,829 patients with T2DM and 20,487 healthy controls. Multiple logistic regression analysis was used to calculate the odds ratio for severe AEs.
RESULTS: After COVID-19 vaccination, patients with T2DM were more likely to experience eight severe AEs than controls: cerebral venous sinus thrombosis, encephalitis myelitis encephalomyelitis, Bell's palsy, lymphadenopathy, ischemic stroke, deep vein thrombosis (DVT), thrombocytopenia (TP), and pulmonary embolism (PE). Moreover, patients with T2DM vaccinated with BNT162b2 and mRNA-1273 were more vulnerable to DVT and TP than those vaccinated with JNJ-78436735. Among patients with T2DM administered mRNA vaccines, mRNA-1273 was safer than BNT162b2 in terms of the risk of DVT and PE.
CONCLUSION: Careful monitoring of severe AEs in patients with T2DM may be necessary, especially for those related to thrombotic events and neurological dysfunctions after COVID-19 vaccination.
| Errataetall: |
CommentIn: Diabetes Metab J. 2023 Sep;47(5):715-716. - PMID 37793981 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:47 |
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| Enthalten in: |
Diabetes & metabolism journal - 47(2023), 3 vom: 03. Mai, Seite 356-365 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kim, Hye Jun [VerfasserIn] |
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| Links: |
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| Themen: |
2019-nCoV Vaccine mRNA-1273 |
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| Anmerkungen: |
Date Completed 02.06.2023 Date Revised 15.02.2024 published: Print-Electronic CommentIn: Diabetes Metab J. 2023 Sep;47(5):715-716. - PMID 37793981 Citation Status MEDLINE |
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| doi: |
10.4093/dmj.2022.0129 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 500 | |a CommentIn: Diabetes Metab J. 2023 Sep;47(5):715-716. - PMID 37793981 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Little is known about the adverse events (AEs) associated with coronavirus disease 2019 (COVID-19) vaccination in patients with type 2 diabetes mellitus (T2DM) | ||
| 520 | |a METHODS: This study used vaccine AE reporting system data to investigate severe AEs among vaccinated patients with T2DM. A natural language processing algorithm was applied to identify people with and without diabetes. After 1:3 matching, we collected data for 6,829 patients with T2DM and 20,487 healthy controls. Multiple logistic regression analysis was used to calculate the odds ratio for severe AEs | ||
| 520 | |a RESULTS: After COVID-19 vaccination, patients with T2DM were more likely to experience eight severe AEs than controls: cerebral venous sinus thrombosis, encephalitis myelitis encephalomyelitis, Bell's palsy, lymphadenopathy, ischemic stroke, deep vein thrombosis (DVT), thrombocytopenia (TP), and pulmonary embolism (PE). Moreover, patients with T2DM vaccinated with BNT162b2 and mRNA-1273 were more vulnerable to DVT and TP than those vaccinated with JNJ-78436735. Among patients with T2DM administered mRNA vaccines, mRNA-1273 was safer than BNT162b2 in terms of the risk of DVT and PE | ||
| 520 | |a CONCLUSION: Careful monitoring of severe AEs in patients with T2DM may be necessary, especially for those related to thrombotic events and neurological dysfunctions after COVID-19 vaccination | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Adverse effects | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Diabetes mellitus, type 2 | |
| 650 | 4 | |a Vaccines | |
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| 700 | 1 | |a Song, Gyuseon |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Chae Won |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Ju Hee |e verfasserin |4 aut | |
| 700 | 1 | |a Shim, Sung Ryul |e verfasserin |4 aut | |
| 700 | 1 | |a Hong, Myunghee |e verfasserin |4 aut | |
| 700 | 1 | |a Han, Hyun Wook |e verfasserin |4 aut | |
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