Scavenging neurotoxic aldehydes using lysine carbon dots
This journal is © The Royal Society of Chemistry..
Reactive aldehydes generated in cells and tissues are associated with adverse physiological effects. Dihydroxyphenylacetaldehyde (DOPAL), the biogenic aldehyde enzymatically produced from dopamine, is cytotoxic, generates reactive oxygen species, and triggers aggregation of proteins such as α-synuclein implicated in Parkinson's disease. Here, we demonstrate that carbon dots (C-dots) prepared from lysine as the carbonaceous precursor bind DOPAL molecules through interactions between the aldehyde units and amine residues on the C-dot surface. A set of biophysical and in vitro experiments attests to attenuation of the adverse biological activity of DOPAL. In particular, we show that the lysine-C-dots inhibit DOPAL-induced α-synuclein oligomerization and cytotoxicity. This work underlines the potential of lysine-C-dots as an effective therapeutic vehicle for aldehyde scavenging.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:5 |
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| Enthalten in: |
Nanoscale advances - 5(2023), 5 vom: 28. Feb., Seite 1356-1367 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Bloch, Daniel Nir [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Revised 04.03.2023 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1039/d2na00804a |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM353721786 |
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| 520 | |a This journal is © The Royal Society of Chemistry. | ||
| 520 | |a Reactive aldehydes generated in cells and tissues are associated with adverse physiological effects. Dihydroxyphenylacetaldehyde (DOPAL), the biogenic aldehyde enzymatically produced from dopamine, is cytotoxic, generates reactive oxygen species, and triggers aggregation of proteins such as α-synuclein implicated in Parkinson's disease. Here, we demonstrate that carbon dots (C-dots) prepared from lysine as the carbonaceous precursor bind DOPAL molecules through interactions between the aldehyde units and amine residues on the C-dot surface. A set of biophysical and in vitro experiments attests to attenuation of the adverse biological activity of DOPAL. In particular, we show that the lysine-C-dots inhibit DOPAL-induced α-synuclein oligomerization and cytotoxicity. This work underlines the potential of lysine-C-dots as an effective therapeutic vehicle for aldehyde scavenging | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Sandre, Michele |e verfasserin |4 aut | |
| 700 | 1 | |a Ben Zichri, Shani |e verfasserin |4 aut | |
| 700 | 1 | |a Masato, Anna |e verfasserin |4 aut | |
| 700 | 1 | |a Kolusheva, Sofiya |e verfasserin |4 aut | |
| 700 | 1 | |a Bubacco, Luigi |e verfasserin |4 aut | |
| 700 | 1 | |a Jelinek, Raz |e verfasserin |4 aut | |
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