Comparison of Preoperative DOI Estimation in Oral Tongue Cancer With cN0 Disease
© 2023 American Academy of Otolaryngology-Head and Neck Surgery Foundation..
OBJECTIVE: To understand the accuracy of pre- and intraoperative estimation of tumor depth of invasion (DOI).
STUDY DESIGN: A retrospective case-control study.
SETTING: Patients who presented at 1 institution with oral tongue squamous cell carcinoma that underwent oncologic resection between 2017 and 2019 were identified.
METHODS: Patients that met the inclusion criteria were included. Patients with nodal, distant, or recurrent disease, prior history of head and neck cancer, or preoperative tumor assessment and/or final histopathology that did not include DOI were excluded. Preoperative DOI estimation and technique and pathology reports were obtained. Our primary outcome was the sensitivity and specificity of DOI estimation modalities including full-thickness biopsy (FTB), manual palpation (MP), punch biopsy (PB), and intraoperative ultrasound (IOUS).
RESULTS: Tumor DOI was assessed quantitatively preoperatively in 40 patients by FTB (n = 19, 48%), MP (n = 17, 42%), or PB (n = 4, 10%). Additionally, 19 patients underwent IOUS to assess DOI. The sensitivities of FTB, MP, and IOUS for DOI ≥ 4 mm were 83% (confidence interval [CI]: 44%-97%), 83% (CI: 55%-95%), and 90% (CI: 60%-98%), respectively, and the specificities were 85% (CI: 58%-96%), 60% (CI: 23%-88%), and 78% (CI: 45%-94%).
CONCLUSION: Our study demonstrated that DOI assessment tools measured had similar sensitivity and specificity in stratifying patients with DOI ≥4 mm, with no statistically superior diagnostic test. Our results support the need for additional research into nodal disease prediction and continued refinement of ND decisions with respect to DOI.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:169 |
|---|---|
| Enthalten in: |
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery - 169(2023), 4 vom: 02. Okt., Seite 948-953 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Au, Vivienne H [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Depth of invasion |
|---|
| Anmerkungen: |
Date Completed 25.09.2023 Date Revised 07.10.2023 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1002/ohn.314 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM353678074 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM353678074 | ||
| 003 | DE-627 | ||
| 005 | 20231226060546.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/ohn.314 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1178.xml |
| 035 | |a (DE-627)NLM353678074 | ||
| 035 | |a (NLM)36861847 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Au, Vivienne H |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Comparison of Preoperative DOI Estimation in Oral Tongue Cancer With cN0 Disease |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 25.09.2023 | ||
| 500 | |a Date Revised 07.10.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023 American Academy of Otolaryngology-Head and Neck Surgery Foundation. | ||
| 520 | |a OBJECTIVE: To understand the accuracy of pre- and intraoperative estimation of tumor depth of invasion (DOI) | ||
| 520 | |a STUDY DESIGN: A retrospective case-control study | ||
| 520 | |a SETTING: Patients who presented at 1 institution with oral tongue squamous cell carcinoma that underwent oncologic resection between 2017 and 2019 were identified | ||
| 520 | |a METHODS: Patients that met the inclusion criteria were included. Patients with nodal, distant, or recurrent disease, prior history of head and neck cancer, or preoperative tumor assessment and/or final histopathology that did not include DOI were excluded. Preoperative DOI estimation and technique and pathology reports were obtained. Our primary outcome was the sensitivity and specificity of DOI estimation modalities including full-thickness biopsy (FTB), manual palpation (MP), punch biopsy (PB), and intraoperative ultrasound (IOUS) | ||
| 520 | |a RESULTS: Tumor DOI was assessed quantitatively preoperatively in 40 patients by FTB (n = 19, 48%), MP (n = 17, 42%), or PB (n = 4, 10%). Additionally, 19 patients underwent IOUS to assess DOI. The sensitivities of FTB, MP, and IOUS for DOI ≥ 4 mm were 83% (confidence interval [CI]: 44%-97%), 83% (CI: 55%-95%), and 90% (CI: 60%-98%), respectively, and the specificities were 85% (CI: 58%-96%), 60% (CI: 23%-88%), and 78% (CI: 45%-94%) | ||
| 520 | |a CONCLUSION: Our study demonstrated that DOI assessment tools measured had similar sensitivity and specificity in stratifying patients with DOI ≥4 mm, with no statistically superior diagnostic test. Our results support the need for additional research into nodal disease prediction and continued refinement of ND decisions with respect to DOI | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a depth of invasion | |
| 650 | 4 | |a full-thickness biopsy | |
| 650 | 4 | |a intraoperative ultrasound | |
| 650 | 4 | |a oral tongue cancer | |
| 700 | 1 | |a Miller, Lauren E |e verfasserin |4 aut | |
| 700 | 1 | |a Deschler, Daniel G |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Derrick T |e verfasserin |4 aut | |
| 700 | 1 | |a Richmon, Jeremy D |e verfasserin |4 aut | |
| 700 | 1 | |a Varvares, Mark A |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery |d 1982 |g 169(2023), 4 vom: 02. Okt., Seite 948-953 |w (DE-627)NLM012595721 |x 1097-6817 |7 nnns |
| 773 | 1 | 8 | |g volume:169 |g year:2023 |g number:4 |g day:02 |g month:10 |g pages:948-953 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1002/ohn.314 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 169 |j 2023 |e 4 |b 02 |c 10 |h 948-953 | ||