Ternary system of sultamicillin tosylate with hydroxypropyl-β-cyclodextrin and L-arginine : susceptibility against methicillin-resistant Staphylococcus aureus
Aim: This study investigated the effect of complex formation between sultamicillin tosylate (ST), hydroxypropyl-β cyclodextrin (HP-βCD) and L-arginine (ARG). Materials & methods: The kneading method was used to prepare the complexes, which were then characterized using SEM, DSC, FT-IR, HPLC, saturation solubility and dissolution studies. The complexes' antibacterial activity against MRSA (ATCC®-43300TM) was evaluated using ZOI and MIC. Results: Solubility was enhanced in the binary and ternary complexes compared with ST (p < 0.001). MIC and ZOI showed that both complexes have increased antibacterial activity compared with ST (p < 0.001) against MRSA. Conclusion: As a result, the inclusion complex of ST with HP-βCD and ARG can be used to improve the physicochemical properties of ST while also improving antibacterial efficacy against MRSA infections.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
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| Enthalten in: |
Therapeutic delivery - 13(2022), 12 vom: 02. Dez., Seite 561-575 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Bolibol, Marvin [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 07.03.2023 Date Revised 08.03.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.4155/tde-2022-0050 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM353672831 |
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| 500 | |a Date Revised 08.03.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Aim: This study investigated the effect of complex formation between sultamicillin tosylate (ST), hydroxypropyl-β cyclodextrin (HP-βCD) and L-arginine (ARG). Materials & methods: The kneading method was used to prepare the complexes, which were then characterized using SEM, DSC, FT-IR, HPLC, saturation solubility and dissolution studies. The complexes' antibacterial activity against MRSA (ATCC®-43300TM) was evaluated using ZOI and MIC. Results: Solubility was enhanced in the binary and ternary complexes compared with ST (p < 0.001). MIC and ZOI showed that both complexes have increased antibacterial activity compared with ST (p < 0.001) against MRSA. Conclusion: As a result, the inclusion complex of ST with HP-βCD and ARG can be used to improve the physicochemical properties of ST while also improving antibacterial efficacy against MRSA infections | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a L-arginine | |
| 650 | 4 | |a hydroxypropyl-β-cyclodextrin | |
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| 650 | 4 | |a methicillin-resistant Staphylococcus aureus | |
| 650 | 4 | |a sultamicillin tosylate | |
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| 650 | 7 | |a 2-Hydroxypropyl-beta-cyclodextrin |2 NLM | |
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| 700 | 1 | |a De Guzman, Liza Marie |e verfasserin |4 aut | |
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