Mesonephric-like adenocarcinoma of the female genital tract : novel observations and detailed molecular characterisation of mixed tumours and mesonephric-like carcinosarcomas
© 2023 The Authors. Histopathology published by John Wiley & Sons Ltd..
AIMS: To report novel observations in five mesonephric-like adenocarcinomas (MLAs) of the female genital tract.
METHODS AND RESULTS: We report two endometrial MLAs in association with endometrioid carcinoma and atypical hyperplasia and three (one endometrial, two ovarian) cases with a sarcomatoid component (mesonephric-like carcinosarcoma). Pathogenic KRAS mutations, which are characteristic of MLA, were identified in all cases although interestingly, in one of the mixed carcinomas, this was confined to the endometrioid component. The concurrent MLA, endometrioid carcinoma and atypical hyperplasia components in one case harboured identical EGFR, PTEN and CCNE1 mutations, suggesting that the atypical hyperplasia gave rise to a Müllerian carcinoma with both endometrioid and mesonephric-like components. The carcinosarcomas all contained a component of MLA and a sarcomatous component with chondroid elements. In the ovarian carcinosarcomas, the coexisting epithelial and sarcomatous components shared some mutations including KRAS and CREBBP, suggesting that they are clonally related. Furthermore, in one case CREBBP and KRAS mutations detected in the MLA and sarcomatous components were also detected in an associated undifferentiated carcinoma component, suggesting that it was clonally related to the MLA and sarcomatous components.
CONCLUSIONS: Our observations provide additional evidence that MLAs have a Müllerian origin and characterise mesonephric-like carcinosarcomas in which chondroid elements appear to be characteristic. In reporting these findings, we provide recommendations for distinction between a mesonephric-like carcinosarcoma and a MLA with a spindle cell component.
| Errataetall: |
CommentIn: Histopathology. 2023 Jun;82(7):974-977. - PMID 37191121 |
|---|---|
| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:82 |
|---|---|
| Enthalten in: |
Histopathology - 82(2023), 7 vom: 04. Juni, Seite 978-990 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Mirkovic, Jelena [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Atypical hyperplasia |
|---|
| Anmerkungen: |
Date Completed 17.05.2023 Date Revised 05.06.2023 published: Print-Electronic CommentIn: Histopathology. 2023 Jun;82(7):974-977. - PMID 37191121 Citation Status MEDLINE |
|---|
| doi: |
10.1111/his.14892 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM353661724 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM353661724 | ||
| 003 | DE-627 | ||
| 005 | 20231226060524.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1111/his.14892 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1178.xml |
| 035 | |a (DE-627)NLM353661724 | ||
| 035 | |a (NLM)36860193 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Mirkovic, Jelena |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Mesonephric-like adenocarcinoma of the female genital tract |b novel observations and detailed molecular characterisation of mixed tumours and mesonephric-like carcinosarcomas |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 17.05.2023 | ||
| 500 | |a Date Revised 05.06.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: Histopathology. 2023 Jun;82(7):974-977. - PMID 37191121 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023 The Authors. Histopathology published by John Wiley & Sons Ltd. | ||
| 520 | |a AIMS: To report novel observations in five mesonephric-like adenocarcinomas (MLAs) of the female genital tract | ||
| 520 | |a METHODS AND RESULTS: We report two endometrial MLAs in association with endometrioid carcinoma and atypical hyperplasia and three (one endometrial, two ovarian) cases with a sarcomatoid component (mesonephric-like carcinosarcoma). Pathogenic KRAS mutations, which are characteristic of MLA, were identified in all cases although interestingly, in one of the mixed carcinomas, this was confined to the endometrioid component. The concurrent MLA, endometrioid carcinoma and atypical hyperplasia components in one case harboured identical EGFR, PTEN and CCNE1 mutations, suggesting that the atypical hyperplasia gave rise to a Müllerian carcinoma with both endometrioid and mesonephric-like components. The carcinosarcomas all contained a component of MLA and a sarcomatous component with chondroid elements. In the ovarian carcinosarcomas, the coexisting epithelial and sarcomatous components shared some mutations including KRAS and CREBBP, suggesting that they are clonally related. Furthermore, in one case CREBBP and KRAS mutations detected in the MLA and sarcomatous components were also detected in an associated undifferentiated carcinoma component, suggesting that it was clonally related to the MLA and sarcomatous components | ||
| 520 | |a CONCLUSIONS: Our observations provide additional evidence that MLAs have a Müllerian origin and characterise mesonephric-like carcinosarcomas in which chondroid elements appear to be characteristic. In reporting these findings, we provide recommendations for distinction between a mesonephric-like carcinosarcoma and a MLA with a spindle cell component | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a atypical hyperplasia | |
| 650 | 4 | |a mesonephric-like adenocarcinoma | |
| 650 | 4 | |a mesonephric-like carcinosarcoma | |
| 650 | 4 | |a molecular analysis | |
| 650 | 4 | |a undifferentiated carcinoma | |
| 650 | 7 | |a Proto-Oncogene Proteins p21(ras) |2 NLM | |
| 650 | 7 | |a EC 3.6.5.2 |2 NLM | |
| 700 | 1 | |a Olkhov-Mitsel, Ekaterina |e verfasserin |4 aut | |
| 700 | 1 | |a Amemiya, Yutaka |e verfasserin |4 aut | |
| 700 | 1 | |a Al-Hussaini, Maysa |e verfasserin |4 aut | |
| 700 | 1 | |a Nofech-Mozes, Sharon |e verfasserin |4 aut | |
| 700 | 1 | |a Djordjevic, Bojana |e verfasserin |4 aut | |
| 700 | 1 | |a Kupets, Rachel |e verfasserin |4 aut | |
| 700 | 1 | |a Seth, Arun |e verfasserin |4 aut | |
| 700 | 1 | |a McCluggage, W Glenn |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Histopathology |d 1985 |g 82(2023), 7 vom: 04. Juni, Seite 978-990 |w (DE-627)NLM000284408 |x 0309-0167 |7 nnns |
| 773 | 1 | 8 | |g volume:82 |g year:2023 |g number:7 |g day:04 |g month:06 |g pages:978-990 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1111/his.14892 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 82 |j 2023 |e 7 |b 04 |c 06 |h 978-990 | ||