Nanodiamond Mediated Molecular Targeting in Pancreatic Ductal Adenocarcinoma : Disrupting the Tumor-stromal Cross-talk, Next Hope on the Horizon?
Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net..
Pancreatic ductal adenocarcinoma (PDAC) is one of the foremost causes of cancer-related morbidities worldwide. Novel nanotechnology-backed drug delivery stratagems, including molecular targeting of the chemotherapeutic payload, have been considered. However, no quantum leap in the gross survival rate of patients with PDAC has been realized. One of the predominant causes behind this is tumor desmoplasia, a dense and heterogenous stromal extracellular matrix of the tumor, aptly termed tumor microenvironment (TME). It plays a pivotal role in the tumor pathogenesis of PDAC as it occupies most of the tumor mass, making PDAC one of the most stromal-rich cancers. The complex crosstalk between the tumor and dynamic components of the TME impacts tumor progression and poses a potential barrier to drug delivery. Understanding and deciphering the complex cascade of tumorstromal interactions are the need of the hour so that we can develop neoteric nano-carriers to disrupt the stroma and target the tumor. Nanodiamonds (NDs), due to their unique surface characteristics, have emerged as a promising nano delivery system in various pre-clinical cancer models and have the potential to deliver the chemotherapeutic payload by moving beyond the dynamic tumor-stromal barrier. It can be the next revolution in nanoparticle-mediated pancreatic cancer targeting.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:23 |
|---|---|
| Enthalten in: |
Current cancer drug targets - 23(2023), 8 vom: 15., Seite 620-633 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Singh, Mohini [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Cancer associated fibroblasts |
|---|
| Anmerkungen: |
Date Completed 19.06.2023 Date Revised 13.12.2023 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.2174/1568009623666230227120837 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM353494879 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM353494879 | ||
| 003 | DE-627 | ||
| 005 | 20231227131134.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.2174/1568009623666230227120837 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1225.xml |
| 035 | |a (DE-627)NLM353494879 | ||
| 035 | |a (NLM)36843367 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Singh, Mohini |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Nanodiamond Mediated Molecular Targeting in Pancreatic Ductal Adenocarcinoma |b Disrupting the Tumor-stromal Cross-talk, Next Hope on the Horizon? |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 19.06.2023 | ||
| 500 | |a Date Revised 13.12.2023 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net. | ||
| 520 | |a Pancreatic ductal adenocarcinoma (PDAC) is one of the foremost causes of cancer-related morbidities worldwide. Novel nanotechnology-backed drug delivery stratagems, including molecular targeting of the chemotherapeutic payload, have been considered. However, no quantum leap in the gross survival rate of patients with PDAC has been realized. One of the predominant causes behind this is tumor desmoplasia, a dense and heterogenous stromal extracellular matrix of the tumor, aptly termed tumor microenvironment (TME). It plays a pivotal role in the tumor pathogenesis of PDAC as it occupies most of the tumor mass, making PDAC one of the most stromal-rich cancers. The complex crosstalk between the tumor and dynamic components of the TME impacts tumor progression and poses a potential barrier to drug delivery. Understanding and deciphering the complex cascade of tumorstromal interactions are the need of the hour so that we can develop neoteric nano-carriers to disrupt the stroma and target the tumor. Nanodiamonds (NDs), due to their unique surface characteristics, have emerged as a promising nano delivery system in various pre-clinical cancer models and have the potential to deliver the chemotherapeutic payload by moving beyond the dynamic tumor-stromal barrier. It can be the next revolution in nanoparticle-mediated pancreatic cancer targeting | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Pancreatic ductal adenocarcinoma | |
| 650 | 4 | |a cancer associated fibroblasts | |
| 650 | 4 | |a desmoplasia | |
| 650 | 4 | |a molecular targeting | |
| 650 | 4 | |a nanodiamonds | |
| 650 | 4 | |a pancreatic stellate cells | |
| 650 | 4 | |a stroma | |
| 650 | 7 | |a Nanodiamonds |2 NLM | |
| 700 | 1 | |a Pal, Paulami |e verfasserin |4 aut | |
| 700 | 1 | |a Dutta, Rajat Subhra |e verfasserin |4 aut | |
| 700 | 1 | |a Marbaniang, Daphisha |e verfasserin |4 aut | |
| 700 | 1 | |a Ray, Subhabrata |e verfasserin |4 aut | |
| 700 | 1 | |a Mazumder, Bhaskar |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Current cancer drug targets |d 2001 |g 23(2023), 8 vom: 15., Seite 620-633 |w (DE-627)NLM120490560 |x 1873-5576 |7 nnns |
| 773 | 1 | 8 | |g volume:23 |g year:2023 |g number:8 |g day:15 |g pages:620-633 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.2174/1568009623666230227120837 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 23 |j 2023 |e 8 |b 15 |h 620-633 | ||