Comparison of serum sIL-2R and LDH levels in patients with intravascular large B-cell lymphoma and patients with advanced stage diffuse large B-cell lymphoma
Intravascular large B-cell lymphoma (IVL) is a rare type of lymphoma characterized by tumor growth selectively within the vessels. The 5th edition of the World Health Organization classification defines IVL as a large B-cell lymphoma, the same as diffuse large B-cell lymphoma, not otherwise specified (DLBCL, NOS). Since the clinical manifestations of IVL are nonspecific, the diagnosis is time-consuming, and the course is often fatal. Serum soluble interleukin-2 receptor (sIL-2R) and serum lactate dehydrogenase (LDH) levels are known to be elevated in a variety of lymphomas. However, the mechanism of sIL-2R elevation in B-cell lymphomas is not fully understood. In this study, we analyzed the serum level of laboratory findings, including sIL-2R and LDH, as well as the presence of B symptoms in 39 patients with IVL, and compared them with 56 patients with stage IV DLBCL. Both sIL-2R and LDH levels were significantly higher in IVL than in DLBCL (p = 0.035 and p = 0.002, respectively). In IVL, there were no significant differences in both sIL-2R and LDH levels between patients with and without B symptoms (p = 0.206 and p = 0.441, respectively). However, in DLBCL, both sIL-2R and LDH levels were significantly higher in the presence of B symptoms (p = 0.001 and p < 0.001, respectively). The high sIL-2R and LDH levels in IVL may be related to the peripheral blood microenvironment, but further studies are needed to verify this.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:63 |
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| Enthalten in: |
Journal of clinical and experimental hematopathology : JCEH - 63(2023), 1 vom: 28. März, Seite 25-31 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hirami, Yuki [VerfasserIn] |
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| Links: |
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| Themen: |
B symptoms |
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| Anmerkungen: |
Date Completed 31.03.2023 Date Revised 06.05.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.3960/jslrt.22043 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM35349190X |
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| 100 | 1 | |a Hirami, Yuki |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Comparison of serum sIL-2R and LDH levels in patients with intravascular large B-cell lymphoma and patients with advanced stage diffuse large B-cell lymphoma |
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| 500 | |a Date Revised 06.05.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Intravascular large B-cell lymphoma (IVL) is a rare type of lymphoma characterized by tumor growth selectively within the vessels. The 5th edition of the World Health Organization classification defines IVL as a large B-cell lymphoma, the same as diffuse large B-cell lymphoma, not otherwise specified (DLBCL, NOS). Since the clinical manifestations of IVL are nonspecific, the diagnosis is time-consuming, and the course is often fatal. Serum soluble interleukin-2 receptor (sIL-2R) and serum lactate dehydrogenase (LDH) levels are known to be elevated in a variety of lymphomas. However, the mechanism of sIL-2R elevation in B-cell lymphomas is not fully understood. In this study, we analyzed the serum level of laboratory findings, including sIL-2R and LDH, as well as the presence of B symptoms in 39 patients with IVL, and compared them with 56 patients with stage IV DLBCL. Both sIL-2R and LDH levels were significantly higher in IVL than in DLBCL (p = 0.035 and p = 0.002, respectively). In IVL, there were no significant differences in both sIL-2R and LDH levels between patients with and without B symptoms (p = 0.206 and p = 0.441, respectively). However, in DLBCL, both sIL-2R and LDH levels were significantly higher in the presence of B symptoms (p = 0.001 and p < 0.001, respectively). The high sIL-2R and LDH levels in IVL may be related to the peripheral blood microenvironment, but further studies are needed to verify this | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a B symptoms | |
| 650 | 4 | |a diffuse large B-cell lymphoma | |
| 650 | 4 | |a intravascular large B-cell lymphoma | |
| 650 | 4 | |a lactate dehydrogenase | |
| 650 | 4 | |a soluble interleukin-2 receptor | |
| 650 | 7 | |a Receptors, Interleukin-2 |2 NLM | |
| 700 | 1 | |a Nishimura, Midori Filiz |e verfasserin |4 aut | |
| 700 | 1 | |a Urata, Tomohiro |e verfasserin |4 aut | |
| 700 | 1 | |a Morimoto, Michiko |e verfasserin |4 aut | |
| 700 | 1 | |a Maekawa, Yukina |e verfasserin |4 aut | |
| 700 | 1 | |a Yoshino, Tadashi |e verfasserin |4 aut | |
| 700 | 1 | |a Nishimura, Yoshito |e verfasserin |4 aut | |
| 700 | 1 | |a Sato, Yasuharu |e verfasserin |4 aut | |
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