Predictors of Progression and Mortality in Patients with Chronic Hypersensitivity Pneumonitis : Retrospective Analysis of Registry of Fibrosing Interstitial Lung Diseases
Hypersensitivity pneumonitis (HP) is an interstitial lung disease (ILD) resulting from an immune-mediated response in susceptible and sensitized individuals to a large variety of inhaled antigens. Chronic HP with a fibrotic phenotype is characterized by disease progression and a dismal prognosis. The aim of this study was to identify predictors of progression and mortality in patients with chronic HP in real clinical practice.
MATERIALS AND METHODS: This retrospective, multicenter, observational study used data from a registry of 1355 patients with fibrosing ILDs. The study included 292 patients diagnosed with chronic HP based on the conclusion of a multidisciplinary discussion (MDD).
RESULTS: The patients were divided into groups with progressive (92 (30.3%) patients) and nonprogressive pulmonary fibrosis (200 (69.7%) patients). The most significant predictors of adverse outcomes were a DLco < 50% predicted, an SpO2 at the end of a six-minute walk test (6-MWT) < 85%, and a GAP score ≥ 4 points.
CONCLUSION: Pulmonary fibrosis and a progressive fibrotic phenotype are common in patients with chronic HP. Early detection of the predictors of an adverse prognosis of chronic HP is necessary for the timely initiation of antifibrotic therapy.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
|---|---|
| Enthalten in: |
Life (Basel, Switzerland) - 13(2023), 2 vom: 08. Feb. |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Trushenko, Natalia V [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Hypersensitivity pneumonitis |
|---|
| Anmerkungen: |
Date Revised 01.03.2023 published: Electronic Citation Status PubMed-not-MEDLINE |
|---|
| doi: |
10.3390/life13020467 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM353429562 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM353429562 | ||
| 003 | DE-627 | ||
| 005 | 20231226055955.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/life13020467 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1178.xml |
| 035 | |a (DE-627)NLM353429562 | ||
| 035 | |a (NLM)36836825 | ||
| 035 | |a (PII)467 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Trushenko, Natalia V |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Predictors of Progression and Mortality in Patients with Chronic Hypersensitivity Pneumonitis |b Retrospective Analysis of Registry of Fibrosing Interstitial Lung Diseases |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 01.03.2023 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Hypersensitivity pneumonitis (HP) is an interstitial lung disease (ILD) resulting from an immune-mediated response in susceptible and sensitized individuals to a large variety of inhaled antigens. Chronic HP with a fibrotic phenotype is characterized by disease progression and a dismal prognosis. The aim of this study was to identify predictors of progression and mortality in patients with chronic HP in real clinical practice | ||
| 520 | |a MATERIALS AND METHODS: This retrospective, multicenter, observational study used data from a registry of 1355 patients with fibrosing ILDs. The study included 292 patients diagnosed with chronic HP based on the conclusion of a multidisciplinary discussion (MDD) | ||
| 520 | |a RESULTS: The patients were divided into groups with progressive (92 (30.3%) patients) and nonprogressive pulmonary fibrosis (200 (69.7%) patients). The most significant predictors of adverse outcomes were a DLco < 50% predicted, an SpO2 at the end of a six-minute walk test (6-MWT) < 85%, and a GAP score ≥ 4 points | ||
| 520 | |a CONCLUSION: Pulmonary fibrosis and a progressive fibrotic phenotype are common in patients with chronic HP. Early detection of the predictors of an adverse prognosis of chronic HP is necessary for the timely initiation of antifibrotic therapy | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a hypersensitivity pneumonitis | |
| 650 | 4 | |a interstitial lung diseases | |
| 650 | 4 | |a mortality | |
| 650 | 4 | |a prognosis | |
| 650 | 4 | |a progressive pulmonary fibrosis | |
| 650 | 4 | |a pulmonary fibrosis | |
| 650 | 4 | |a registry | |
| 700 | 1 | |a Suvorova, Olga A |e verfasserin |4 aut | |
| 700 | 1 | |a Pershina, Ekaterina S |e verfasserin |4 aut | |
| 700 | 1 | |a Nekludova, Galina V |e verfasserin |4 aut | |
| 700 | 1 | |a Chikina, Svetlana Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Levina, Iuliia A |e verfasserin |4 aut | |
| 700 | 1 | |a Chernyaev, Andrey L |e verfasserin |4 aut | |
| 700 | 1 | |a Samsonova, Maria V |e verfasserin |4 aut | |
| 700 | 1 | |a Tyurin, Igor E |e verfasserin |4 aut | |
| 700 | 1 | |a Mustafina, Malika Kh |e verfasserin |4 aut | |
| 700 | 1 | |a Yaroshetskiy, Andrey I |e verfasserin |4 aut | |
| 700 | 1 | |a Nadtochiy, Nikita B |e verfasserin |4 aut | |
| 700 | 1 | |a Merzhoeva, Zamira M |e verfasserin |4 aut | |
| 700 | 1 | |a Proshkina, Anna A |e verfasserin |4 aut | |
| 700 | 1 | |a Avdeev, Sergey N |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Life (Basel, Switzerland) |d 2011 |g 13(2023), 2 vom: 08. Feb. |w (DE-627)NLM243284799 |x 2075-1729 |7 nnns |
| 773 | 1 | 8 | |g volume:13 |g year:2023 |g number:2 |g day:08 |g month:02 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.3390/life13020467 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 13 |j 2023 |e 2 |b 08 |c 02 | ||