Deep Learning Approach for Predicting the Therapeutic Usages of Unani Formulas towards Finding Essential Compounds
The use of herbal medicines in recent decades has increased because their side effects are considered lower than conventional medicine. Unani herbal medicines are often used in Southern Asia. These herbal medicines are usually composed of several types of medicinal plants to treat various diseases. Research on herbal medicine usually focuses on insight into the composition of plants used as ingredients. However, in the present study, we extended to the level of metabolites that exist in the medicinal plants. This study aimed to develop a predictive model of the Unani therapeutic usage based on its constituent metabolites using deep learning and data-intensive science approaches. Furthermore, the best prediction model was then utilized to extract important metabolites for each therapeutic usage of Unani. In this study, it was observed that the deep neural network approach provided a much better prediction model than other algorithms including random forest and support vector machine. Moreover, according to the best prediction model using the deep neural network, we identified 118 important metabolites for nine therapeutic usages of Unani.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
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| Enthalten in: |
Life (Basel, Switzerland) - 13(2023), 2 vom: 03. Feb. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wijaya, Sony Hartono [VerfasserIn] |
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| Links: |
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| Themen: |
Deep learning |
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| Anmerkungen: |
Date Revised 28.02.2023 published: Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3390/life13020439 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM353429287 |
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| 520 | |a The use of herbal medicines in recent decades has increased because their side effects are considered lower than conventional medicine. Unani herbal medicines are often used in Southern Asia. These herbal medicines are usually composed of several types of medicinal plants to treat various diseases. Research on herbal medicine usually focuses on insight into the composition of plants used as ingredients. However, in the present study, we extended to the level of metabolites that exist in the medicinal plants. This study aimed to develop a predictive model of the Unani therapeutic usage based on its constituent metabolites using deep learning and data-intensive science approaches. Furthermore, the best prediction model was then utilized to extract important metabolites for each therapeutic usage of Unani. In this study, it was observed that the deep neural network approach provided a much better prediction model than other algorithms including random forest and support vector machine. Moreover, according to the best prediction model using the deep neural network, we identified 118 important metabolites for nine therapeutic usages of Unani | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Unani | |
| 650 | 4 | |a deep learning | |
| 650 | 4 | |a herbal medicine | |
| 650 | 4 | |a metabolomics | |
| 650 | 4 | |a prediction | |
| 700 | 1 | |a Nasution, Ahmad Kamal |e verfasserin |4 aut | |
| 700 | 1 | |a Batubara, Irmanida |e verfasserin |4 aut | |
| 700 | 1 | |a Gao, Pei |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Ming |e verfasserin |4 aut | |
| 700 | 1 | |a Ono, Naoaki |e verfasserin |4 aut | |
| 700 | 1 | |a Kanaya, Shigehiko |e verfasserin |4 aut | |
| 700 | 1 | |a Altaf-Ul-Amin, Md |e verfasserin |4 aut | |
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