Construction and evaluation of an antioxidant synergistic system containing vitamin C and vitamin E
AIMS: The aim of this study is to develop a liposome that could exert unparalleled antioxidant effects. In the present study, a vitamin C (VC)/vitamin E (VE)-co-loaded multivesicular liposome (VCVE-MVL) was constructed.
METHODS: Vitamins were encapsulated in soybean phosphatidylcholine (SPC) and cholesterol (CHO) by multi-emulsification method. The concentration of VC was determined by Fast Blue method. The concentration of VE was determined by high performance liquid chromatography (HPLC). Vitamin antioxidant capacity in vitro and in vivo was determined using β-carotene bleaching.
RESULTS: VCVE-MVL with particle diameter of 848.55 ± 0.29 nm and SPAN of 0.16 ± 0.11 were obtained. The encapsulation efficiency of VC reached 48.51% (w/w)±0.15. Compared with VC/VE solution, VCVE-MVL had a higher permeation efficiency. In addition, the in vitro and ex-vivo antioxidant tests verified the adequate antioxidant activity of VCVE-MVL.
CONCLUSIONS: In conclusion, the antioxidant synergistic system we constructed and demonstrated its potential applications in the cosmetics industry.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:40 |
|---|---|
| Enthalten in: |
Journal of microencapsulation - 40(2023), 3 vom: 24. Mai, Seite 157-170 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Tao, Ran [VerfasserIn] |
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| Links: |
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| Themen: |
1406-18-4 |
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| Anmerkungen: |
Date Completed 10.04.2023 Date Revised 10.04.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/02652048.2023.2183276 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM353318418 |
|---|
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| 100 | 1 | |a Tao, Ran |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Construction and evaluation of an antioxidant synergistic system containing vitamin C and vitamin E |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 500 | |a Date Completed 10.04.2023 | ||
| 500 | |a Date Revised 10.04.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a AIMS: The aim of this study is to develop a liposome that could exert unparalleled antioxidant effects. In the present study, a vitamin C (VC)/vitamin E (VE)-co-loaded multivesicular liposome (VCVE-MVL) was constructed | ||
| 520 | |a METHODS: Vitamins were encapsulated in soybean phosphatidylcholine (SPC) and cholesterol (CHO) by multi-emulsification method. The concentration of VC was determined by Fast Blue method. The concentration of VE was determined by high performance liquid chromatography (HPLC). Vitamin antioxidant capacity in vitro and in vivo was determined using β-carotene bleaching | ||
| 520 | |a RESULTS: VCVE-MVL with particle diameter of 848.55 ± 0.29 nm and SPAN of 0.16 ± 0.11 were obtained. The encapsulation efficiency of VC reached 48.51% (w/w)±0.15. Compared with VC/VE solution, VCVE-MVL had a higher permeation efficiency. In addition, the in vitro and ex-vivo antioxidant tests verified the adequate antioxidant activity of VCVE-MVL | ||
| 520 | |a CONCLUSIONS: In conclusion, the antioxidant synergistic system we constructed and demonstrated its potential applications in the cosmetics industry | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Vitamin C | |
| 650 | 4 | |a antioxidant | |
| 650 | 4 | |a liposomes | |
| 650 | 4 | |a transdermal permeability | |
| 650 | 4 | |a vitamin E | |
| 650 | 7 | |a Antioxidants |2 NLM | |
| 650 | 7 | |a Vitamin E |2 NLM | |
| 650 | 7 | |a 1406-18-4 |2 NLM | |
| 650 | 7 | |a Ascorbic Acid |2 NLM | |
| 650 | 7 | |a PQ6CK8PD0R |2 NLM | |
| 650 | 7 | |a Liposomes |2 NLM | |
| 650 | 7 | |a Vitamins |2 NLM | |
| 700 | 1 | |a Zhang, Qianyu |e verfasserin |4 aut | |
| 700 | 1 | |a Duan, Jialing |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Ran |e verfasserin |4 aut | |
| 700 | 1 | |a Yao, Liyun |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Ruiteng |e verfasserin |4 aut | |
| 700 | 1 | |a Dong, Gang |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Huali |e verfasserin |4 aut | |
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