Fetal MRI based brain atlas analysis detects initial in utero effects of prenatal alcohol exposure
© The Author(s) 2023. Published by Oxford University Press..
Prenatal alcohol exposure (PAE) can change the normal trajectory of human fetal brain development and may lead to long-lasting neurodevelopmental changes in the form of fetal alcohol spectrum disorders. Currently, early prenatal patterns of alcohol-related central nervous system changes are unclear and it is unknown if small amounts of PAE may result in early detectable brain anomalies. This super-resolution fetal magnetic resonance imaging (MRI) study aimed to identify regional effects of PAE on human brain structure. Fetuses were prospectively assessed using atlas-based semi-automated 3-dimensional tissue segmentation based on 1.5 T and 3 T fetal brain MRI examinations. After expectant mothers completed anonymized PRAMS and TACE questionnaires for PAE, fetuses without gross macroscopic brain abnormalities were identified and analyzed. Linear mixed-effects modeling of regional brain volumes was conducted and multiple comparisons were corrected using the Benjamini-Hochberg procedure. In total, 500 pregnant women were recruited with 51 reporting gestational alcohol consumption. After excluding confounding comorbidities, 24 fetuses (26 observations) were identified with PAE and 52 age-matched controls without PAE were analyzed. Patients with PAE showed significantly larger volumes of the corpus callosum (P ≤ 0.001) and smaller volumes of the periventricular zone (P = 0.001). Even minor (1-3 standard drinks per week) PAE changed the neurodevelopmental trajectory.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:33 |
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| Enthalten in: |
Cerebral cortex (New York, N.Y. : 1991) - 33(2023), 11 vom: 24. Mai, Seite 6852-6861 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Stuempflen, Marlene [VerfasserIn] |
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| Links: |
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| Themen: |
Brain atlas |
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| Anmerkungen: |
Date Completed 02.06.2023 Date Revised 06.06.2023 published: Print Citation Status MEDLINE |
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| doi: |
10.1093/cercor/bhad005 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM353137847 |
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| 245 | 1 | 0 | |a Fetal MRI based brain atlas analysis detects initial in utero effects of prenatal alcohol exposure |
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| 520 | |a Prenatal alcohol exposure (PAE) can change the normal trajectory of human fetal brain development and may lead to long-lasting neurodevelopmental changes in the form of fetal alcohol spectrum disorders. Currently, early prenatal patterns of alcohol-related central nervous system changes are unclear and it is unknown if small amounts of PAE may result in early detectable brain anomalies. This super-resolution fetal magnetic resonance imaging (MRI) study aimed to identify regional effects of PAE on human brain structure. Fetuses were prospectively assessed using atlas-based semi-automated 3-dimensional tissue segmentation based on 1.5 T and 3 T fetal brain MRI examinations. After expectant mothers completed anonymized PRAMS and TACE questionnaires for PAE, fetuses without gross macroscopic brain abnormalities were identified and analyzed. Linear mixed-effects modeling of regional brain volumes was conducted and multiple comparisons were corrected using the Benjamini-Hochberg procedure. In total, 500 pregnant women were recruited with 51 reporting gestational alcohol consumption. After excluding confounding comorbidities, 24 fetuses (26 observations) were identified with PAE and 52 age-matched controls without PAE were analyzed. Patients with PAE showed significantly larger volumes of the corpus callosum (P ≤ 0.001) and smaller volumes of the periventricular zone (P = 0.001). Even minor (1-3 standard drinks per week) PAE changed the neurodevelopmental trajectory | ||
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| 650 | 4 | |a brain atlas | |
| 650 | 4 | |a fetal alcohol spectrum disorders | |
| 650 | 4 | |a fetal brain | |
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| 650 | 4 | |a prenatal alcohol exposure | |
| 700 | 1 | |a Schwartz, Ernst |e verfasserin |4 aut | |
| 700 | 1 | |a Diogo, Mariana C |e verfasserin |4 aut | |
| 700 | 1 | |a Glatter, Sarah |e verfasserin |4 aut | |
| 700 | 1 | |a Pfeiler, Birgit |e verfasserin |4 aut | |
| 700 | 1 | |a Kienast, Patric |e verfasserin |4 aut | |
| 700 | 1 | |a Taymourtash, Athena |e verfasserin |4 aut | |
| 700 | 1 | |a Schmidbauer, Victor U |e verfasserin |4 aut | |
| 700 | 1 | |a Bartha-Doering, Lisa |e verfasserin |4 aut | |
| 700 | 1 | |a Krampl-Bettelheim, Elisabeth |e verfasserin |4 aut | |
| 700 | 1 | |a Seidl, Rainer |e verfasserin |4 aut | |
| 700 | 1 | |a Langs, Georg |e verfasserin |4 aut | |
| 700 | 1 | |a Prayer, Daniela |e verfasserin |4 aut | |
| 700 | 1 | |a Kasprian, Gregor |e verfasserin |4 aut | |
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