Oncological and functional impact of adjuvant treatments after open partial laryngeal surgery : a systematic review of the literature and a meta-analysis
© 2023. The Author(s)..
BACKGROUND: The oncological and functional role of postoperative radiotherapy (PORT) after open partial laryngeal surgery (OPLS) remains debatable.
METHODS: A systematic review and a meta-analysis of the literature were conducted according to the PRISMA guidelines. Outcomes of patients receiving OPLS with and without PORT for laryngeal cancer were summarized.
RESULTS: In the 10 studies that were included in the meta-analysis, no significant difference emerged in terms of pooled overall survival between OPLS patients who did and who did not receive PORT (- 0.3%, 95% CI - 5.4 to 4.9%, p = 0.922). Only one study showed a significantly higher incidence of complications in the PORT cohort.
CONCLUSIONS: PORT may apparently be performed after OPLS in face of adverse postoperative features without an increased risk of toxicities affecting the neolarynx. Because of the limitations in the available literature, the oncological and functional effects of PORT in this setting needs to be prospectively assessed to strengthen the evidence of this treatment strategy for laryngeal cancer.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2023 |
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Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:280 |
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Enthalten in: |
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery - 280(2023), 6 vom: 20. Juni, Seite 2911-2926 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Locatello, Luca Giovanni [VerfasserIn] |
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Links: |
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Themen: |
Adjuvant radiotherapy |
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Anmerkungen: |
Date Completed 15.05.2023 Date Revised 24.05.2023 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1007/s00405-023-07871-8 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM353133671 |
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520 | |a © 2023. The Author(s). | ||
520 | |a BACKGROUND: The oncological and functional role of postoperative radiotherapy (PORT) after open partial laryngeal surgery (OPLS) remains debatable | ||
520 | |a METHODS: A systematic review and a meta-analysis of the literature were conducted according to the PRISMA guidelines. Outcomes of patients receiving OPLS with and without PORT for laryngeal cancer were summarized | ||
520 | |a RESULTS: In the 10 studies that were included in the meta-analysis, no significant difference emerged in terms of pooled overall survival between OPLS patients who did and who did not receive PORT (- 0.3%, 95% CI - 5.4 to 4.9%, p = 0.922). Only one study showed a significantly higher incidence of complications in the PORT cohort | ||
520 | |a CONCLUSIONS: PORT may apparently be performed after OPLS in face of adverse postoperative features without an increased risk of toxicities affecting the neolarynx. Because of the limitations in the available literature, the oncological and functional effects of PORT in this setting needs to be prospectively assessed to strengthen the evidence of this treatment strategy for laryngeal cancer | ||
650 | 4 | |a Systematic Review | |
650 | 4 | |a Meta-Analysis | |
650 | 4 | |a Journal Article | |
650 | 4 | |a Adjuvant radiotherapy | |
650 | 4 | |a Functional outcomes | |
650 | 4 | |a Laryngeal cancer | |
650 | 4 | |a Laryngeal surgery | |
650 | 4 | |a OPLS | |
650 | 4 | |a PORT | |
650 | 4 | |a Partial laryngectomy | |
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