Selective inhibition of peptidyl-arginine deiminase (PAD) : can it control multiple inflammatory disorders as a promising therapeutic strategy?

© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG..

Peptidyl arginine deiminases (PADs) are a family of post-translational modification enzymes that irreversibly citrullinate (deiminate) arginine residues of protein and convert them to a non-classical amino acid citrulline in the presence of calcium ions. It has five isotypes, such as PAD1, PAD2, PAD3, PAD4, and PAD6, found in mammalian species. It has been suggested that increased PAD expression in various tissues contributes to the development of multiple inflammatory diseases, including rheumatoid arthritis (RA), cancer, diabetes, and neurological disorders. Elevation of PAD enzyme expression depends on several factors like rising intracellular Ca2+ levels, oxidative stress, and proinflammatory cytokines. PAD inhibitors originating from natural or synthetic sources can be used as a novel therapeutic approach concerning inflammatory disorders. Here, we review the pathological role of PAD in several inflammatory disorders, factors that trigger PAD expression, epigenetic role and finally, decipher the therapeutic approach of PAD inhibitors in multiple inflammatory disorders.

Medienart:

E-Artikel

Erscheinungsjahr:

2023

Erschienen:

2023

Enthalten in:

Zur Gesamtaufnahme - volume:31

Enthalten in:

Inflammopharmacology - 31(2023), 2 vom: 05. Apr., Seite 731-744

Sprache:

Englisch

Beteiligte Personen:

Padhy, Dibya Sundar [VerfasserIn]
Palit, Partha [VerfasserIn]
Ikbal, Abu Md Ashif [VerfasserIn]
Das, Nirupam [VerfasserIn]
Roy, Dilip Kumar [VerfasserIn]
Banerjee, Sugato [VerfasserIn]

Links:

Volltext

Themen:

94ZLA3W45F
Arginine
Arginine deiminase
EC 3.-
EC 3.5.3.15
EC 3.5.3.6
Hydrolases
Inflammatory disorders
Journal Article
Neurodegenerative disorders
PAD inhibitors
Peptidyl arginine deiminase (PAD)
Protein-Arginine Deiminases
Proteins
Review

Anmerkungen:

Date Completed 01.05.2023

Date Revised 01.05.2023

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1007/s10787-023-01149-5

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM353133345