Central visual field damage in glaucoma eyes with choroidal microvasculature dropout with and without high axial myopia
© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ..
PURPOSE: To characterise the relationship between a deep-layer microvasculature dropout (MvD) and central visual field (VF) damage in primary open-angle glaucoma (POAG) patients with and without high axial myopia.
DESIGN: Cross-sectional study.
METHODS: Seventy-one eyes (49 patients) with high axial myopia and POAG and 125 non-highly myopic POAG eyes (97 patients) were enrolled. Presence, area and angular circumference of juxtapapillary MvD were evaluated on optical coherence tomography angiography B-scans and en-face choroidal images.
RESULTS: Juxtapapillary MvD was detected more often in the highly myopic POAG eyes (43 eyes, 86%) than in the non-highly myopic eyes (73 eyes, 61.9%; p=0.002). In eyes with MvD, MvD area and angular circumference (95% CI) were significantly larger in the highly myopic eyes compared with the non-highly myopic eyes (area: (0.69 (0.40, 0.98) mm2 vs 0.31 (0.19, 0.42) mm2, p=0.011) and (angular circumference: 84.3 (62.9, 105.8) vs 74.5 (58.3, 90.9) degrees, p<0.001), respectively. 24-2 VF mean deviation (MD) was significantly worse in eyes with MvD compared with eyes without MvD in both groups (p<0.001). After adjusting for 24-2 MD VF, central VF defects were more frequently found in eyes with MvD compared with eyes without MvD (82.7% vs 60.9%, p<0.001). In multivariable analysis, higher intraocular pressure, worse 24-2 VF MD, longer axial length and greater MvD area and angular circumference were associated with worse 10-2 VF MD.
CONCLUSIONS: MvD was more prevalent and larger in POAG eyes with high myopia than in non-highly myopic POAG eyes. In both groups, eyes with MvD showed worse glaucoma severity and more central VF defects.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:108 |
|---|---|
| Enthalten in: |
The British journal of ophthalmology - 108(2024), 3 vom: 21. Feb., Seite 372-379 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Micheletti, Eleonora [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Choroid |
|---|
| Anmerkungen: |
Date Completed 23.02.2024 Date Revised 06.03.2024 published: Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1136/bjo-2022-322234 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM353122416 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM353122416 | ||
| 003 | DE-627 | ||
| 005 | 20240307231851.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1136/bjo-2022-322234 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1319.xml |
| 035 | |a (DE-627)NLM353122416 | ||
| 035 | |a (NLM)36805846 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Micheletti, Eleonora |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Central visual field damage in glaucoma eyes with choroidal microvasculature dropout with and without high axial myopia |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 23.02.2024 | ||
| 500 | |a Date Revised 06.03.2024 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ. | ||
| 520 | |a PURPOSE: To characterise the relationship between a deep-layer microvasculature dropout (MvD) and central visual field (VF) damage in primary open-angle glaucoma (POAG) patients with and without high axial myopia | ||
| 520 | |a DESIGN: Cross-sectional study | ||
| 520 | |a METHODS: Seventy-one eyes (49 patients) with high axial myopia and POAG and 125 non-highly myopic POAG eyes (97 patients) were enrolled. Presence, area and angular circumference of juxtapapillary MvD were evaluated on optical coherence tomography angiography B-scans and en-face choroidal images | ||
| 520 | |a RESULTS: Juxtapapillary MvD was detected more often in the highly myopic POAG eyes (43 eyes, 86%) than in the non-highly myopic eyes (73 eyes, 61.9%; p=0.002). In eyes with MvD, MvD area and angular circumference (95% CI) were significantly larger in the highly myopic eyes compared with the non-highly myopic eyes (area: (0.69 (0.40, 0.98) mm2 vs 0.31 (0.19, 0.42) mm2, p=0.011) and (angular circumference: 84.3 (62.9, 105.8) vs 74.5 (58.3, 90.9) degrees, p<0.001), respectively. 24-2 VF mean deviation (MD) was significantly worse in eyes with MvD compared with eyes without MvD in both groups (p<0.001). After adjusting for 24-2 MD VF, central VF defects were more frequently found in eyes with MvD compared with eyes without MvD (82.7% vs 60.9%, p<0.001). In multivariable analysis, higher intraocular pressure, worse 24-2 VF MD, longer axial length and greater MvD area and angular circumference were associated with worse 10-2 VF MD | ||
| 520 | |a CONCLUSIONS: MvD was more prevalent and larger in POAG eyes with high myopia than in non-highly myopic POAG eyes. In both groups, eyes with MvD showed worse glaucoma severity and more central VF defects | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Choroid | |
| 650 | 4 | |a Glaucoma | |
| 650 | 4 | |a Imaging | |
| 650 | 4 | |a Intraocular pressure | |
| 650 | 4 | |a Optic Nerve | |
| 700 | 1 | |a El-Nimri, Nevin |e verfasserin |4 aut | |
| 700 | 1 | |a Nishida, Takashi |e verfasserin |4 aut | |
| 700 | 1 | |a Moghimi, Sasan |e verfasserin |4 aut | |
| 700 | 1 | |a Rezapour, Jasmin |e verfasserin |4 aut | |
| 700 | 1 | |a Fazio, Massimo A |e verfasserin |4 aut | |
| 700 | 1 | |a Suh, Min Hee |e verfasserin |4 aut | |
| 700 | 1 | |a Bowd, Christopher |e verfasserin |4 aut | |
| 700 | 1 | |a Belghith, Akram |e verfasserin |4 aut | |
| 700 | 1 | |a Christopher, Mark |e verfasserin |4 aut | |
| 700 | 1 | |a Jonas, Jost B |e verfasserin |4 aut | |
| 700 | 1 | |a Weinreb, Robert N |e verfasserin |4 aut | |
| 700 | 1 | |a Zangwill, Linda M |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The British journal of ophthalmology |d 1917 |g 108(2024), 3 vom: 21. Feb., Seite 372-379 |w (DE-627)NLM000087556 |x 1468-2079 |7 nnns |
| 773 | 1 | 8 | |g volume:108 |g year:2024 |g number:3 |g day:21 |g month:02 |g pages:372-379 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1136/bjo-2022-322234 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 108 |j 2024 |e 3 |b 21 |c 02 |h 372-379 | ||