CanVasc consensus recommendations for the use of avacopan in antineutrophil cytoplasm antibody-associated vasculitis : 2022 addendum
© The Author(s) 2023. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissionsoup.com..
OBJECTIVE: In 2020, the Canadian Vasculitis Research Network (CanVasc) published their updated recommendations for the management of ANCA-associated vasculitides (AAV). The current addendum provides further recommendations regarding the use of avacopan in AAV based on a review of newly available evidence.
METHODS: An updated systematic literature review on avacopan (formerly, CCX168) using Medline, Embase, and the Cochrane Library was performed for publications up to September 2022. New recommendations were developed and categorized according to the EULAR grading levels, as done for previous CanVasc recommendations. A modified Delphi procedure and videoconferences were used to reach ≥80% consensus on the inclusion, wording and grading of each recommendation.
RESULTS: Three new recommendations were developed. They focus on avacopan therapy indication and duration, as well as timely glucocorticoid tapering.
CONCLUSION: These 2022 addended recommendations provide rheumatologists, nephrologists and other specialists caring for patients with AAV with guidance for the use of avacopan, based on current evidence and consensus from Canadian experts.
| Errataetall: |
CommentIn: Rheumatology (Oxford). 2023 Aug 1;62(8):2633-2634. - PMID 37084252 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:62 |
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| Enthalten in: |
Rheumatology (Oxford, England) - 62(2023), 8 vom: 01. Aug., Seite 2646-2651 |
| Sprache: |
Englisch |
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| Links: |
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| Anmerkungen: |
Date Completed 03.08.2023 Date Revised 03.08.2023 published: Print CommentIn: Rheumatology (Oxford). 2023 Aug 1;62(8):2633-2634. - PMID 37084252 Citation Status MEDLINE |
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| doi: |
10.1093/rheumatology/kead087 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 100 | 1 | |a Turgeon, David |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a CanVasc consensus recommendations for the use of avacopan in antineutrophil cytoplasm antibody-associated vasculitis |b 2022 addendum |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Completed 03.08.2023 | ||
| 500 | |a Date Revised 03.08.2023 | ||
| 500 | |a published: Print | ||
| 500 | |a CommentIn: Rheumatology (Oxford). 2023 Aug 1;62(8):2633-2634. - PMID 37084252 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © The Author(s) 2023. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissionsoup.com. | ||
| 520 | |a OBJECTIVE: In 2020, the Canadian Vasculitis Research Network (CanVasc) published their updated recommendations for the management of ANCA-associated vasculitides (AAV). The current addendum provides further recommendations regarding the use of avacopan in AAV based on a review of newly available evidence | ||
| 520 | |a METHODS: An updated systematic literature review on avacopan (formerly, CCX168) using Medline, Embase, and the Cochrane Library was performed for publications up to September 2022. New recommendations were developed and categorized according to the EULAR grading levels, as done for previous CanVasc recommendations. A modified Delphi procedure and videoconferences were used to reach ≥80% consensus on the inclusion, wording and grading of each recommendation | ||
| 520 | |a RESULTS: Three new recommendations were developed. They focus on avacopan therapy indication and duration, as well as timely glucocorticoid tapering | ||
| 520 | |a CONCLUSION: These 2022 addended recommendations provide rheumatologists, nephrologists and other specialists caring for patients with AAV with guidance for the use of avacopan, based on current evidence and consensus from Canadian experts | ||
| 650 | 4 | |a Systematic Review | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a ANCA | |
| 650 | 4 | |a anti-neutrophil cytoplasm antibody-associated vasculitis | |
| 650 | 4 | |a avacopan | |
| 650 | 4 | |a glomerulonephritis | |
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