Turning gray selenium and sublimed sulfur into a nanocomposite to accelerate tissue regeneration by isothermal recrystallization
© 2023. The Author(s)..
BACKGROUND: Globally, millions of patients suffer from regenerative deficiencies, such as refractory wound healing, which is characterized by excessive inflammation and abnormal angiogenesis. Growth factors and stem cells are currently employed to accelerate tissue repair and regeneration; however, they are complex and costly. Thus, the exploration of new regeneration accelerators is of considerable medical interest. This study developed a plain nanoparticle that accelerates tissue regeneration with the involvement of angiogenesis and inflammatory regulation.
METHODS: Grey selenium and sublimed sulphur were thermalized in PEG-200 and isothermally recrystallised to composite nanoparticles (Nano-SeS). The tissue regeneration accelerating activities of Nano-Se@S were evaluated in mice, zebrafish, chick embryos, and human cells. Transcriptomic analysis was performed to investigate the potential mechanisms involved during tissue regeneration.
RESULTS: Through the cooperation of sulphur, which is inert to tissue regeneration, Nano-SeS demonstrated improved tissue regeneration acceleration activity compared to Nano-Se. Transcriptome analysis revealed that Nano-Se@S improved biosynthesis and ROS scavenging but suppressed inflammation. The ROS scavenging and angiogenesis-promoting activities of Nano-Se@S were further confirmed in transgenic zebrafish and chick embryos. Interestingly, we found that Nano-Se@S recruits leukocytes to the wound surface at the early stage of regeneration, which contributes to sterilization during regeneration.
CONCLUSION: Our study highlights Nano-SeS as a tissue regeneration accelerator, and Nano-Se@S may provide new inspiration for therapeutics for regenerative-deficient diseases.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:21 |
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| Enthalten in: |
Journal of nanobiotechnology - 21(2023), 1 vom: 21. Feb., Seite 57 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Cao, Jieqiong [VerfasserIn] |
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| Links: |
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| Themen: |
70FD1KFU70 |
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| Anmerkungen: |
Date Completed 23.02.2023 Date Revised 02.11.2023 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1186/s12951-023-01796-4 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM353101877 |
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| 100 | 1 | |a Cao, Jieqiong |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Turning gray selenium and sublimed sulfur into a nanocomposite to accelerate tissue regeneration by isothermal recrystallization |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Completed 23.02.2023 | ||
| 500 | |a Date Revised 02.11.2023 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023. The Author(s). | ||
| 520 | |a BACKGROUND: Globally, millions of patients suffer from regenerative deficiencies, such as refractory wound healing, which is characterized by excessive inflammation and abnormal angiogenesis. Growth factors and stem cells are currently employed to accelerate tissue repair and regeneration; however, they are complex and costly. Thus, the exploration of new regeneration accelerators is of considerable medical interest. This study developed a plain nanoparticle that accelerates tissue regeneration with the involvement of angiogenesis and inflammatory regulation | ||
| 520 | |a METHODS: Grey selenium and sublimed sulphur were thermalized in PEG-200 and isothermally recrystallised to composite nanoparticles (Nano-SeS). The tissue regeneration accelerating activities of Nano-Se@S were evaluated in mice, zebrafish, chick embryos, and human cells. Transcriptomic analysis was performed to investigate the potential mechanisms involved during tissue regeneration | ||
| 520 | |a RESULTS: Through the cooperation of sulphur, which is inert to tissue regeneration, Nano-SeS demonstrated improved tissue regeneration acceleration activity compared to Nano-Se. Transcriptome analysis revealed that Nano-Se@S improved biosynthesis and ROS scavenging but suppressed inflammation. The ROS scavenging and angiogenesis-promoting activities of Nano-Se@S were further confirmed in transgenic zebrafish and chick embryos. Interestingly, we found that Nano-Se@S recruits leukocytes to the wound surface at the early stage of regeneration, which contributes to sterilization during regeneration | ||
| 520 | |a CONCLUSION: Our study highlights Nano-SeS as a tissue regeneration accelerator, and Nano-Se@S may provide new inspiration for therapeutics for regenerative-deficient diseases | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Low toxicity | |
| 650 | 4 | |a Nanocomposite | |
| 650 | 4 | |a Nanoengineering | |
| 650 | 4 | |a Tissue regeneration | |
| 650 | 7 | |a Selenium |2 NLM | |
| 650 | 7 | |a H6241UJ22B |2 NLM | |
| 650 | 7 | |a Reactive Oxygen Species |2 NLM | |
| 650 | 7 | |a Sulfur |2 NLM | |
| 650 | 7 | |a 70FD1KFU70 |2 NLM | |
| 700 | 1 | |a Zhang, Yibo |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Yiqi |e verfasserin |4 aut | |
| 700 | 1 | |a Xie, Junye |e verfasserin |4 aut | |
| 700 | 1 | |a Su, Zijian |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Fu |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Jingsheng |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Bihui |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Zhenyu |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Peiguang |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Zhixin |e verfasserin |4 aut | |
| 700 | 1 | |a He, Liu |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Hongwei |e verfasserin |4 aut | |
| 700 | 1 | |a Zheng, Wenjie |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Shuixing |e verfasserin |4 aut | |
| 700 | 1 | |a Hong, An |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Xiaojia |e verfasserin |4 aut | |
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