Trends in chronic hepatitis B virus infection in Italy over a 10-year period : Clues from the nationwide PITER and MASTER cohorts toward elimination
Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved..
OBJECTIVES: The study measures trends in the profile of patients with chronic hepatitis B virus linked to care in Italy.
METHODS: A cross-sectional, multicenter, observational cohort (PITER cohort) of consecutive patients with hepatitis B surface antigen (HBsAg) over the period 2019-2021 from 46 centers was evaluated. The reference was the MASTER cohort collected over the years 2012-2015. Standard statistical methods were used.
RESULTS: The PITER cohort enrolled 4583 patients, of whom 21.8% were non-Italian natives. Compared with those in MASTER, the patients were older and more often female. The prevalence of hepatitis B e antigen (HBeAg) declined (7.2% vs 12.3; P <0.0001) and that of anti-hepatitis D virus (HDV) remained stable (9.3% vs 8.3%). In both cohorts, about 25% of the patients had cirrhosis, and those in the PITER cohort were older. HBeAg-positive was 5.0% vs 12.6% (P <0.0001) and anti-HDV positive 24.8% vs 17.5% (P <0.0017). In the logistic model, the variables associated with cirrhosis were anti-HDV-positive (odds ratio = 10.08; confidence interval 7.63-13.43), age, sex, and body mass index; the likelihood of cirrhosis was reduced by 40% in the PITER cohort. Among non-Italians, 12.3% were HBeAg-positive (vs 23.4% in the MASTER cohort; P <0.0001), and 12.3% were anti-HDV-positive (vs 11.1%). Overall, the adherence to the European Association for the Study of the Liver recommendations for antiviral treatment increased over time.
CONCLUSION: Chronic hepatitis B virus infection appears to be in the process of becoming under control in Italy; however, HDV infection is still a health concern in patients with cirrhosis and in migrants.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:129 |
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| Enthalten in: |
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 129(2023) vom: 13. Apr., Seite 266-273 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Brancaccio, Giuseppina [VerfasserIn] |
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| Links: |
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| Themen: |
Chronic |
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| Anmerkungen: |
Date Completed 21.03.2023 Date Revised 21.03.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ijid.2023.02.006 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM352984163 |
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| 100 | 1 | |a Brancaccio, Giuseppina |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Trends in chronic hepatitis B virus infection in Italy over a 10-year period |b Clues from the nationwide PITER and MASTER cohorts toward elimination |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
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| 500 | |a Date Completed 21.03.2023 | ||
| 500 | |a Date Revised 21.03.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved. | ||
| 520 | |a OBJECTIVES: The study measures trends in the profile of patients with chronic hepatitis B virus linked to care in Italy | ||
| 520 | |a METHODS: A cross-sectional, multicenter, observational cohort (PITER cohort) of consecutive patients with hepatitis B surface antigen (HBsAg) over the period 2019-2021 from 46 centers was evaluated. The reference was the MASTER cohort collected over the years 2012-2015. Standard statistical methods were used | ||
| 520 | |a RESULTS: The PITER cohort enrolled 4583 patients, of whom 21.8% were non-Italian natives. Compared with those in MASTER, the patients were older and more often female. The prevalence of hepatitis B e antigen (HBeAg) declined (7.2% vs 12.3; P <0.0001) and that of anti-hepatitis D virus (HDV) remained stable (9.3% vs 8.3%). In both cohorts, about 25% of the patients had cirrhosis, and those in the PITER cohort were older. HBeAg-positive was 5.0% vs 12.6% (P <0.0001) and anti-HDV positive 24.8% vs 17.5% (P <0.0017). In the logistic model, the variables associated with cirrhosis were anti-HDV-positive (odds ratio = 10.08; confidence interval 7.63-13.43), age, sex, and body mass index; the likelihood of cirrhosis was reduced by 40% in the PITER cohort. Among non-Italians, 12.3% were HBeAg-positive (vs 23.4% in the MASTER cohort; P <0.0001), and 12.3% were anti-HDV-positive (vs 11.1%). Overall, the adherence to the European Association for the Study of the Liver recommendations for antiviral treatment increased over time | ||
| 520 | |a CONCLUSION: Chronic hepatitis B virus infection appears to be in the process of becoming under control in Italy; however, HDV infection is still a health concern in patients with cirrhosis and in migrants | ||
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Chronic | |
| 650 | 4 | |a Epidemiology | |
| 650 | 4 | |a Hepatitis B | |
| 650 | 4 | |a Hepatitis Delta | |
| 650 | 4 | |a Hepatitis control | |
| 650 | 4 | |a Migrants | |
| 650 | 7 | |a Hepatitis B e Antigens |2 NLM | |
| 650 | 7 | |a Hepatitis B Surface Antigens |2 NLM | |
| 700 | 1 | |a Coco, Barbara |e verfasserin |4 aut | |
| 700 | 1 | |a Nardi, Alessandra |e verfasserin |4 aut | |
| 700 | 1 | |a Quaranta, Maria Giovanna |e verfasserin |4 aut | |
| 700 | 1 | |a Tosti, Maria Elena |e verfasserin |4 aut | |
| 700 | 1 | |a Ferrigno, Luigina |e verfasserin |4 aut | |
| 700 | 1 | |a Cacciola, Irene |e verfasserin |4 aut | |
| 700 | 1 | |a Messina, Vincenzo |e verfasserin |4 aut | |
| 700 | 1 | |a Chessa, Luchino |e verfasserin |4 aut | |
| 700 | 1 | |a Morisco, Filomena |e verfasserin |4 aut | |
| 700 | 1 | |a Milella, Michele |e verfasserin |4 aut | |
| 700 | 1 | |a Barbaro, Francesco |e verfasserin |4 aut | |
| 700 | 1 | |a Ciancio, Alessia |e verfasserin |4 aut | |
| 700 | 1 | |a Russo, Francesco Paolo |e verfasserin |4 aut | |
| 700 | 1 | |a Coppola, Nicola |e verfasserin |4 aut | |
| 700 | 1 | |a Blanc, Pierluigi |e verfasserin |4 aut | |
| 700 | 1 | |a Claar, Ernesto |e verfasserin |4 aut | |
| 700 | 1 | |a Verucchi, Gabriella |e verfasserin |4 aut | |
| 700 | 1 | |a Puoti, Massimo |e verfasserin |4 aut | |
| 700 | 1 | |a Zignego, Anna Linda |e verfasserin |4 aut | |
| 700 | 1 | |a Chemello, Liliana |e verfasserin |4 aut | |
| 700 | 1 | |a Madonia, Salvatore |e verfasserin |4 aut | |
| 700 | 1 | |a Fagiuoli, Stefano |e verfasserin |4 aut | |
| 700 | 1 | |a Marzano, Alfredo |e verfasserin |4 aut | |
| 700 | 1 | |a Ferrari, Carlo |e verfasserin |4 aut | |
| 700 | 1 | |a Lampertico, Pietro |e verfasserin |4 aut | |
| 700 | 1 | |a Di Marco, Vito |e verfasserin |4 aut | |
| 700 | 1 | |a Craxì, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Santantonio, Teresa Antonia |e verfasserin |4 aut | |
| 700 | 1 | |a Raimondo, Giovanni |e verfasserin |4 aut | |
| 700 | 1 | |a Brunetto, Maurizia R |e verfasserin |4 aut | |
| 700 | 1 | |a Gaeta, Giovanni Battista |e verfasserin |4 aut | |
| 700 | 1 | |a Kondili, Loreta A |e verfasserin |4 aut | |
| 700 | 0 | |a PITER collaborating investigators |e verfasserin |4 aut | |
| 700 | 1 | |a Pasulo, Luisa |e investigator |4 oth | |
| 700 | 1 | |a Coppola, Carmine |e investigator |4 oth | |
| 700 | 1 | |a Pisano, Federica |e investigator |4 oth | |
| 700 | 1 | |a Romano, Mariarosaria |e investigator |4 oth | |
| 700 | 1 | |a Porcu, Carmen |e investigator |4 oth | |
| 700 | 1 | |a Bottalico, Irene Francesca |e investigator |4 oth | |
| 700 | 1 | |a Cossiga, Valentina |e investigator |4 oth | |
| 700 | 1 | |a Tata, Xhimi |e investigator |4 oth | |
| 700 | 1 | |a Sagnelli, Caterina |e investigator |4 oth | |
| 700 | 1 | |a Pierotti, Piera |e investigator |4 oth | |
| 700 | 1 | |a Degasperi, Elisabetta |e investigator |4 oth | |
| 700 | 1 | |a Rosato, Valerio |e investigator |4 oth | |
| 700 | 1 | |a Badia, Lorenzo |e investigator |4 oth | |
| 700 | 1 | |a Ieluzzi, Dontella |e investigator |4 oth | |
| 700 | 1 | |a Monti, Monica |e investigator |4 oth | |
| 700 | 1 | |a Bavetta, Maria Grazia |e investigator |4 oth | |
| 700 | 1 | |a Cavalletto, Luisa |e investigator |4 oth | |
| 700 | 1 | |a Toniutto, Pierluigi |e investigator |4 oth | |
| 700 | 1 | |a Fornasiere, Ezio |e investigator |4 oth | |
| 700 | 1 | |a Colecchia, Antonio |e investigator |4 oth | |
| 700 | 1 | |a Ferrarese, Alberto |e investigator |4 oth | |
| 700 | 1 | |a Nardone, Gerardo |e investigator |4 oth | |
| 700 | 1 | |a Rocco, Alba |e investigator |4 oth | |
| 700 | 1 | |a Viganò, Mauro |e investigator |4 oth | |
| 700 | 1 | |a Foschi, Francesco Giuseppe |e investigator |4 oth | |
| 700 | 1 | |a Conti, Fabio |e investigator |4 oth | |
| 700 | 1 | |a Morsica, Giulia |e investigator |4 oth | |
| 700 | 1 | |a Salpietro, Stefania |e investigator |4 oth | |
| 700 | 1 | |a Torti, Carlo |e investigator |4 oth | |
| 700 | 1 | |a Costa, Chiara |e investigator |4 oth | |
| 700 | 1 | |a Federico, Alessandro |e investigator |4 oth | |
| 700 | 1 | |a Dallio, Marcello |e investigator |4 oth | |
| 700 | 1 | |a Giorgini, Alessia |e investigator |4 oth | |
| 700 | 1 | |a Anselmo, Marco |e investigator |4 oth | |
| 700 | 1 | |a De Leo, Pasqualina |e investigator |4 oth | |
| 700 | 1 | |a Zaltron, Serena |e investigator |4 oth | |
| 700 | 1 | |a Cambianica, Anna |e investigator |4 oth | |
| 700 | 1 | |a Piscaglia, Fabio |e investigator |4 oth | |
| 700 | 1 | |a Serio, Ilaria |e investigator |4 oth | |
| 700 | 1 | |a Schivazappa, Simona |e investigator |4 oth | |
| 700 | 1 | |a Mastroianni, Antonio |e investigator |4 oth | |
| 700 | 1 | |a Chidichimo, Luciana |e investigator |4 oth | |
| 700 | 1 | |a Massari, Marco |e investigator |4 oth | |
| 700 | 1 | |a Mazzaro, Cesare |e investigator |4 oth | |
| 700 | 1 | |a Marrone, Aldo |e investigator |4 oth | |
| 700 | 1 | |a D'Amore, Francesca Maria |e investigator |4 oth | |
| 700 | 1 | |a D'Offizi, Gianpiero |e investigator |4 oth | |
| 700 | 1 | |a Licata, Anna |e investigator |4 oth | |
| 700 | 1 | |a Niro, Grazia Anna |e investigator |4 oth | |
| 700 | 1 | |a Pollicino, Teresa |e investigator |4 oth | |
| 700 | 1 | |a Aghemo, Alessio |e investigator |4 oth | |
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