Clinical performance of rapid antigen tests in comparison to RT-PCR for SARS-COV-2 diagnosis in Omicron variant : A systematic review and meta-analysis
© 2023 John Wiley & Sons Ltd..
The Omicron variant of concern has a high level of mutations in different genes that has raised awareness about the performance of immunological products such as vaccines and antigen detection kits. In this systematic review and meta-analysis, we investigated whether Omicron had a significant influence on rapid antigen test (RAT) performance in comparison to PCR. We registered this systematic review and meta-analysis in PROSPERO with the registration number CRD42022355510. We searched PubMed, Scopus, Embase, and Web of Science databases systematically to 1 August 2022. After article screening, we assessed the quality of the included studies based on the JBI checklist. Following data extraction, we performed a meta-analysis using R software. We included 18 qualified articles presenting sufficient data about RATs performance in comparison to RT-PCR in Omicron infections. The pooled specificity and sensitivity of RATs were 1.000 (0.997-1.000) and 0.671 (0.595-0.721), respectively. The FDA-approved kits showed a better performance than WHO-approved ones with a sensitivity of 0.728 (0.620-0.815). The use of RATs with nasal swabs showed a higher sensitivity compared with nasopharyngeal swabs. The sensitivity for samples with a CT-value >25 was 0.108 (0.048-0.227). Rapid antigen tests show impaired performance for COVID-19 diagnosis when the Omicron variant is circulating, particularly in samples with low viral loads.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2023 |
---|---|
Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:33 |
---|---|
Enthalten in: |
Reviews in medical virology - 33(2023), 2 vom: 07. März, Seite e2428 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Mohammadie, Zahra Eslami [VerfasserIn] |
---|
Links: |
---|
Themen: |
B.1.1.529 |
---|
Anmerkungen: |
Date Completed 14.03.2023 Date Revised 29.03.2023 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1002/rmv.2428 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM352973943 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM352973943 | ||
003 | DE-627 | ||
005 | 20231226054933.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231226s2023 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1002/rmv.2428 |2 doi | |
028 | 5 | 2 | |a pubmed24n1176.xml |
035 | |a (DE-627)NLM352973943 | ||
035 | |a (NLM)36790832 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Mohammadie, Zahra Eslami |e verfasserin |4 aut | |
245 | 1 | 0 | |a Clinical performance of rapid antigen tests in comparison to RT-PCR for SARS-COV-2 diagnosis in Omicron variant |b A systematic review and meta-analysis |
264 | 1 | |c 2023 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 14.03.2023 | ||
500 | |a Date Revised 29.03.2023 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a © 2023 John Wiley & Sons Ltd. | ||
520 | |a The Omicron variant of concern has a high level of mutations in different genes that has raised awareness about the performance of immunological products such as vaccines and antigen detection kits. In this systematic review and meta-analysis, we investigated whether Omicron had a significant influence on rapid antigen test (RAT) performance in comparison to PCR. We registered this systematic review and meta-analysis in PROSPERO with the registration number CRD42022355510. We searched PubMed, Scopus, Embase, and Web of Science databases systematically to 1 August 2022. After article screening, we assessed the quality of the included studies based on the JBI checklist. Following data extraction, we performed a meta-analysis using R software. We included 18 qualified articles presenting sufficient data about RATs performance in comparison to RT-PCR in Omicron infections. The pooled specificity and sensitivity of RATs were 1.000 (0.997-1.000) and 0.671 (0.595-0.721), respectively. The FDA-approved kits showed a better performance than WHO-approved ones with a sensitivity of 0.728 (0.620-0.815). The use of RATs with nasal swabs showed a higher sensitivity compared with nasopharyngeal swabs. The sensitivity for samples with a CT-value >25 was 0.108 (0.048-0.227). Rapid antigen tests show impaired performance for COVID-19 diagnosis when the Omicron variant is circulating, particularly in samples with low viral loads | ||
650 | 4 | |a Meta-Analysis | |
650 | 4 | |a Systematic Review | |
650 | 4 | |a Journal Article | |
650 | 4 | |a Review | |
650 | 4 | |a B.1.1.529 | |
650 | 4 | |a COVID-19 | |
650 | 4 | |a Omicron | |
650 | 4 | |a RT-PCR | |
650 | 4 | |a diagnosis | |
650 | 4 | |a rapid antigen test | |
700 | 1 | |a Akhlaghi, Saeed |e verfasserin |4 aut | |
700 | 1 | |a Samaeinasab, Saeed |e verfasserin |4 aut | |
700 | 1 | |a Shaterzadeh-Bojd, Shakiba |e verfasserin |4 aut | |
700 | 1 | |a Jamialahmadi, Tannaz |e verfasserin |4 aut | |
700 | 1 | |a Sahebkar, Amirhossein |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Reviews in medical virology |d 1996 |g 33(2023), 2 vom: 07. März, Seite e2428 |w (DE-627)NLM090684788 |x 1099-1654 |7 nnns |
773 | 1 | 8 | |g volume:33 |g year:2023 |g number:2 |g day:07 |g month:03 |g pages:e2428 |
856 | 4 | 0 | |u http://dx.doi.org/10.1002/rmv.2428 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 33 |j 2023 |e 2 |b 07 |c 03 |h e2428 |