Interleukin 18 (IL-18) and IL-3 in Extracellular Vesicles : Biomarkers for Durable Elite Control of HIV-1
© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America..
Plasma extracellular vesicle (EV)-associated cytokines were quantified in people with HIV (PWH) with different virological control status, including elite controllers (EC) who maintain persistent control (PC) or not (TC). Cytokine signatures and pathways were determined for each group. Median EV-associated cytokine levels were higher among PWH than HIV-uninfected. EC showed the highest levels of EV-associated cytokines among PWH with PC levels higher than TC levels. IL-18 levels best distinguished PWH from uninfected controls, and EC from ART-treated, and IL-3 distinguished PC from TC. The role of EV-cytokines in intercellular communication and endogenous control of HIV expression should be investigated further.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:227 |
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| Enthalten in: |
The Journal of infectious diseases - 227(2023), 12 vom: 15. Juni, Seite 1381-1385 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Poveda, Eva [VerfasserIn] |
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| Links: |
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| Themen: |
Biomarkers |
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| Anmerkungen: |
Date Completed 16.06.2023 Date Revised 23.06.2023 published: Print Citation Status MEDLINE |
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| doi: |
10.1093/infdis/jiad042 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM352973781 |
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| 520 | |a © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. | ||
| 520 | |a Plasma extracellular vesicle (EV)-associated cytokines were quantified in people with HIV (PWH) with different virological control status, including elite controllers (EC) who maintain persistent control (PC) or not (TC). Cytokine signatures and pathways were determined for each group. Median EV-associated cytokine levels were higher among PWH than HIV-uninfected. EC showed the highest levels of EV-associated cytokines among PWH with PC levels higher than TC levels. IL-18 levels best distinguished PWH from uninfected controls, and EC from ART-treated, and IL-3 distinguished PC from TC. The role of EV-cytokines in intercellular communication and endogenous control of HIV expression should be investigated further | ||
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| 650 | 4 | |a functional cure | |
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| 650 | 7 | |a Cytokines |2 NLM | |
| 650 | 7 | |a Biomarkers |2 NLM | |
| 700 | 1 | |a Fitzgerald, Wendy |e verfasserin |4 aut | |
| 700 | 1 | |a Reglero, Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a Pérez-González, Alexandre |e verfasserin |4 aut | |
| 700 | 1 | |a Mariño, Ana |e verfasserin |4 aut | |
| 700 | 1 | |a Álvarez, Hortensia |e verfasserin |4 aut | |
| 700 | 1 | |a Valcarce, Nieves |e verfasserin |4 aut | |
| 700 | 1 | |a Llibre, Josep Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Guillén, Santiago Moreno |e verfasserin |4 aut | |
| 700 | 1 | |a Muñoz Fernández, Maria Angeles |e verfasserin |4 aut | |
| 700 | 1 | |a Ruiz-Mateos, Ezequiel |e verfasserin |4 aut | |
| 700 | 1 | |a Margolis, Leonid |e verfasserin |4 aut | |
| 700 | 1 | |a Lederman, Michael M |e verfasserin |4 aut | |
| 700 | 1 | |a Freeman, Michael L |e verfasserin |4 aut | |
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