Sex differences in dementia risk and risk factors : Individual-participant data analysis using 21 cohorts across six continents from the COSMIC consortium
© 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association..
INTRODUCTION: Sex differences in dementia risk, and risk factor (RF) associations with dementia, remain uncertain across diverse ethno-regional groups.
METHODS: A total of 29,850 participants (58% women) from 21 cohorts across six continents were included in an individual participant data meta-analysis. Sex-specific hazard ratios (HRs), and women-to-men ratio of hazard ratios (RHRs) for associations between RFs and all-cause dementia were derived from mixed-effect Cox models.
RESULTS: Incident dementia occurred in 2089 (66% women) participants over 4.6 years (median). Women had higher dementia risk (HR, 1.12 [1.02, 1.23]) than men, particularly in low- and lower-middle-income economies. Associations between longer education and former alcohol use with dementia risk (RHR, 1.01 [1.00, 1.03] per year, and 0.55 [0.38, 0.79], respectively) were stronger for men than women; otherwise, there were no discernible sex differences in other RFs.
DISCUSSION: Dementia risk was higher in women than men, with possible variations by country-level income settings, but most RFs appear to work similarly in women and men.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:19 |
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| Enthalten in: |
Alzheimer's & dementia : the journal of the Alzheimer's Association - 19(2023), 8 vom: 01. Aug., Seite 3365-3378 |
| Sprache: |
Englisch |
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| Links: |
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| Themen: |
Data harmonization |
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| Anmerkungen: |
Date Completed 11.08.2023 Date Revised 23.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/alz.12962 |
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| Förderinstitution / Projekttitel: |
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| 100 | 1 | |a Gong, Jessica |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Sex differences in dementia risk and risk factors |b Individual-participant data analysis using 21 cohorts across six continents from the COSMIC consortium |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Completed 11.08.2023 | ||
| 500 | |a Date Revised 23.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. | ||
| 520 | |a INTRODUCTION: Sex differences in dementia risk, and risk factor (RF) associations with dementia, remain uncertain across diverse ethno-regional groups | ||
| 520 | |a METHODS: A total of 29,850 participants (58% women) from 21 cohorts across six continents were included in an individual participant data meta-analysis. Sex-specific hazard ratios (HRs), and women-to-men ratio of hazard ratios (RHRs) for associations between RFs and all-cause dementia were derived from mixed-effect Cox models | ||
| 520 | |a RESULTS: Incident dementia occurred in 2089 (66% women) participants over 4.6 years (median). Women had higher dementia risk (HR, 1.12 [1.02, 1.23]) than men, particularly in low- and lower-middle-income economies. Associations between longer education and former alcohol use with dementia risk (RHR, 1.01 [1.00, 1.03] per year, and 0.55 [0.38, 0.79], respectively) were stronger for men than women; otherwise, there were no discernible sex differences in other RFs | ||
| 520 | |a DISCUSSION: Dementia risk was higher in women than men, with possible variations by country-level income settings, but most RFs appear to work similarly in women and men | ||
| 650 | 4 | |a Meta-Analysis | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a data harmonization | |
| 650 | 4 | |a dementia | |
| 650 | 4 | |a diversity | |
| 650 | 4 | |a risk factor | |
| 650 | 4 | |a sex difference | |
| 700 | 1 | |a Harris, Katie |e verfasserin |4 aut | |
| 700 | 1 | |a Lipnicki, Darren M |e verfasserin |4 aut | |
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| 700 | 1 | |a Lima-Costa, Maria Fernanda |e verfasserin |4 aut | |
| 700 | 1 | |a Diniz, Breno S |e verfasserin |4 aut | |
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