Total Antioxidant Capacity and Total Oxidant Status and Disease Severity in a Cohort Study of COVID-19 Patients
BACKGROUND: Previous reports have suggested the role of oxidative stress in progression of COVID-19 infection, but there is limited information regarding the effect of antioxidant capacity and total oxidant status of patients with COVID-19 on disease severity. In the present study, we aimed to investigate the relationship between total antioxidant capacity (TAC), total oxidant status (TOS), TAC/TOS levels, and disease severity in hospitalized patients with COVID-19.
METHODS: This cohort study was carried out at Masih Daneshvari Hospital in Tehran, Iran, from September 2020 to October 2020. Clinical data of 331 patients with COVID-19 admitted to the hospital were analyzed and divided into mild, moderate, and severe groups (needed oxygen, intubation, and mechanical ventilation). The patients' TAC, TOS, and TAC/TOS levels were assessed using the serum samples by colorimetric assay kit.
RESULTS: We found no significant difference in serum levels of TAC, TOS, and TAC/TOS in terms of the disease severity.
CONCLUSIONS: These results indicated that total antioxidant capacity and total oxidant status may not be the determining factor on the disease severity.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:69 |
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| Enthalten in: |
Clinical laboratory - 69(2023), 2 vom: 01. Feb. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Esmaeili-Nadimi, Ali [VerfasserIn] |
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| Anmerkungen: |
Date Completed 16.02.2023 Date Revised 18.05.2023 published: Print Citation Status MEDLINE |
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| doi: |
10.7754/Clin.Lab.2022.220416 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM352941677 |
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| 520 | |a BACKGROUND: Previous reports have suggested the role of oxidative stress in progression of COVID-19 infection, but there is limited information regarding the effect of antioxidant capacity and total oxidant status of patients with COVID-19 on disease severity. In the present study, we aimed to investigate the relationship between total antioxidant capacity (TAC), total oxidant status (TOS), TAC/TOS levels, and disease severity in hospitalized patients with COVID-19 | ||
| 520 | |a METHODS: This cohort study was carried out at Masih Daneshvari Hospital in Tehran, Iran, from September 2020 to October 2020. Clinical data of 331 patients with COVID-19 admitted to the hospital were analyzed and divided into mild, moderate, and severe groups (needed oxygen, intubation, and mechanical ventilation). The patients' TAC, TOS, and TAC/TOS levels were assessed using the serum samples by colorimetric assay kit | ||
| 520 | |a RESULTS: We found no significant difference in serum levels of TAC, TOS, and TAC/TOS in terms of the disease severity | ||
| 520 | |a CONCLUSIONS: These results indicated that total antioxidant capacity and total oxidant status may not be the determining factor on the disease severity | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 7 | |a Oxidants |2 NLM | |
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| 700 | 1 | |a Alizadeh, Samira |e verfasserin |4 aut | |
| 700 | 1 | |a Vatannejad, Akram |e verfasserin |4 aut | |
| 700 | 1 | |a Mohaghegh, Pegah |e verfasserin |4 aut | |
| 700 | 1 | |a Seyedmehdi, Seyed M |e verfasserin |4 aut | |
| 700 | 1 | |a La Vecchia, Carlo |e verfasserin |4 aut | |
| 700 | 1 | |a Jamali, Zahra |e verfasserin |4 aut | |
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