RETRACTED : Deletion of the scavenger receptor Scarb1 in myeloid cells does not affect bone mass
Published by Elsevier Inc..
The scavenger receptor class B member 1 (SR-B1 or Scarb1) is a glycosylated cell surface receptor for high density lipoproteins (HDL), oxidized low density lipoproteins (OxLDL), and phosphocholine-containing oxidized phospholipids (PC-OxPLs). Scarb1 is expressed in macrophages and has been shown to have both pro- and anti-atherogenic properties. It has been reported that global deletion of Scarb1 in mice leads to either high or low bone mass and that PC-OxPLs decrease osteoblastogenesis and increase osteoclastogenesis. PC-OxPLs decrease bone mass in 6-month-old mice and are critical pathogenetic factors in the bone loss caused by high fat diet or aging. We have investigated here whether Scarb1 expression in myeloid cells affects bone mass and whether PC-OxPLs exert their anti-osteogenic effects via activation of Scarb1 in macrophages. To this end, we generated mice with deletion of Scarb1 in LysM-Cre expressing cells and found that lack of Scarb1 did not affect bone mass in vivo. These results indicate that Scarb1 expression in cells of the myeloid/osteoclast lineage does not contribute to bone homeostasis. Based on this evidence, and earlier studies of ours showing that Scarb1 expression in osteoblasts does not affect bone mass, we conclude that Scarb1 is not an important mediator of the adverse effects on PC-OxPLs in osteoclasts or osteoblasts in 6-month-old mice.
| Errataetall: | |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:170 |
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| Enthalten in: |
Bone - 170(2023) vom: 01. Mai, Seite 116702 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Palmieri, Michela [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 20.03.2023 Date Revised 04.10.2023 published: Print-Electronic RetractionIn: Bone. 2023 Aug 24;176:116885. - PMID 37633107 Citation Status MEDLINE |
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| doi: |
10.1016/j.bone.2023.116702 |
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| Förderinstitution / Projekttitel: |
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NLM352835834 |
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| 500 | |a RetractionIn: Bone. 2023 Aug 24;176:116885. - PMID 37633107 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Published by Elsevier Inc. | ||
| 520 | |a The scavenger receptor class B member 1 (SR-B1 or Scarb1) is a glycosylated cell surface receptor for high density lipoproteins (HDL), oxidized low density lipoproteins (OxLDL), and phosphocholine-containing oxidized phospholipids (PC-OxPLs). Scarb1 is expressed in macrophages and has been shown to have both pro- and anti-atherogenic properties. It has been reported that global deletion of Scarb1 in mice leads to either high or low bone mass and that PC-OxPLs decrease osteoblastogenesis and increase osteoclastogenesis. PC-OxPLs decrease bone mass in 6-month-old mice and are critical pathogenetic factors in the bone loss caused by high fat diet or aging. We have investigated here whether Scarb1 expression in myeloid cells affects bone mass and whether PC-OxPLs exert their anti-osteogenic effects via activation of Scarb1 in macrophages. To this end, we generated mice with deletion of Scarb1 in LysM-Cre expressing cells and found that lack of Scarb1 did not affect bone mass in vivo. These results indicate that Scarb1 expression in cells of the myeloid/osteoclast lineage does not contribute to bone homeostasis. Based on this evidence, and earlier studies of ours showing that Scarb1 expression in osteoblasts does not affect bone mass, we conclude that Scarb1 is not an important mediator of the adverse effects on PC-OxPLs in osteoclasts or osteoblasts in 6-month-old mice | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, U.S. Gov't, Non-P.H.S. | |
| 650 | 4 | |a Retracted Publication | |
| 650 | 4 | |a Bone mass | |
| 650 | 4 | |a Macrophages | |
| 650 | 4 | |a Osteoclasts | |
| 650 | 4 | |a Oxidized phospholipids | |
| 650 | 4 | |a Scavenger receptor class B member 1 (SR-B1 or Scarb1) | |
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| 700 | 1 | |a Joseph, Teenamol E |e verfasserin |4 aut | |
| 700 | 1 | |a O'Brien, Charles A |e verfasserin |4 aut | |
| 700 | 1 | |a Gomez-Acevedo, Horacio |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Ha-Neui |e verfasserin |4 aut | |
| 700 | 1 | |a Manolagas, Stavros C |e verfasserin |4 aut | |
| 700 | 1 | |a Ambrogini, Elena |e verfasserin |4 aut | |
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